Aseptic manipulation system

Patent metadata

Field	Value
Publication number	US-2016339130-A1
Application number	US-201515112248-A
Country	US
Kind code	A1
Filing date	Jan 7, 2015
Priority date	Jan 27, 2014
Publication date	Nov 24, 2016
Grant date	—

Abstract

A decontamination operation chamber is partitioned into a first operation chamber and a second operation chamber. A connecting portion that connects the first operation chamber and the second operation chamber can be closed. The pressure of the first operation chamber and the second operation chamber is adjusted by a pressure-adjusting mechanism. When the connecting portion is opened and the first operation chamber and the second operation chamber are connected, an inlet portion for the first operation chamber and an outlet portion for the second operation chamber are closed and air flow is generated from the second operation chamber to the first operation chamber by the pressure-adjusting mechanism. When carrying an object into an aseptic manipulation chamber, the object is housed in the first operation chamber and a first decontamination operation is performed, then the object is transferred to the second operation chamber and a second decontamination operation is performed.

First claim

1 . An aseptic manipulation system comprising an aseptic manipulation chamber, the inside of which is kept in an aseptic condition, and a decontamination chamber provided for removing microbes adhering to an object carried into the aseptic manipulation chamber from the outside thereof;
the decontamination chamber having a first operation chamber provided with an inlet portion that can be closed, a second operation chamber connected to the first operation chamber and provided with an outlet portion that can be closed, and a closable communication portion for communicating between the first operation chamber and the second operation chamber, the decontamination chamber being connected to a pressure-adjusting mechanism adjusting the pressure of the first operation chamber and the second operation chamber; when the communication portion is open for communication between the first operation chamber and the second operation chamber, the inlet portion and the outlet portion are closed, and an air current from the second operation chamber to the first operation chamber is generated by the pressure-adjusting mechanism; and when an object is carried into the aseptic manipulation chamber from the outside thereof, the object is stored in the first operation chamber to undergo a first decontamination, the object is then moved from the first operation chamber to the second operation chamber through the communication portion to undergo a second decontamination in the second operation chamber, and is then carried into the aseptic manipulation chamber.

2 . The aseptic manipulation system according to claim 1 , wherein the pressure-adjusting mechanism comprises:
a first air supply and exhaust mechanism that supplies air to and exhausts air from the first operation chamber; and a second air supply and exhaust mechanism that supplies air to and exhausts air from the second operation chamber; the first and second air supply and exhaust mechanisms setting the air supply amount to the second operation chamber greater than that to the first operation chamber, and setting the air exhaust amount from the first operation chamber greater than that from the second operation chamber, in a state in which the communication portion is open.

3 . The aseptic manipulation system according to claim 1 , wherein, in the first decontamination performed in the first operation chamber, the first operation chamber is filled with decontamination gas to apply the decontamination gas to an object that is to be carried into the aseptic manipulation chamber, and in the second decontamination performed in the second operation chamber, the decontamination gas residue remaining on the object is removed.

4 . The aseptic manipulation system according to claim 1 , wherein, in the first decontamination performed in the first operation chamber, microbes adhering to the object that is to be carried into the aseptic manipulation chamber are removed using a first decontamination medium, and
in the second decontamination performed in the second operation chamber, the microbes adhering to the object are removed using a second decontamination medium different from the first decontamination medium.

5 . The aseptic manipulation system according to claim 2 , wherein, in the first decontamination performed in the first operation chamber, the first operation chamber is filled with decontamination gas to apply the decontamination gas to an object that is to be carried into the aseptic manipulation chamber, and in the second decontamination performed in the second operation chamber, the decontamination gas residue remaining on the object is removed.

6 . The aseptic manipulation system according to claim 2 , wherein, in the first decontamination performed in the first operation chamber, microbes adhering to the object that is to be carried into the aseptic manipulation chamber are removed using a first decontamination medium, and
in the second decontamination performed in the second operation chamber, the microbes adhering to the object are removed using a second decontamination medium different from the first decontamination medium.

Assignees

• Shibuya Corp

Inventors

• Shomura Masaharu
• FUNAZUKA Takuya

Classifications

• C12M37/00

  Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination (C12M23/38 takes precedence; filtration in general and filters per se B01D24/00-B01D41/00; autoclaves B01J3/04; treatment of microorganisms with electrical or wave energy C12N13/00) · CPC title

• F24F3/161

  Mechanical Engineering · mapped topic

• F24F2003/1614

  Mechanical Engineering · mapped topic

• C12M41/40

  of pressure · CPC title

• A61L2/20 Primary

  Gaseous substances, e.g. vapours · CPC title