Compositions and Methods of Reducing Dry Mouth

Patent metadata

Field	Value
Publication number	US-2016338922-A1
Application number	US-201615227080-A
Country	US
Kind code	A1
Filing date	Aug 3, 2016
Priority date	Aug 7, 2010
Publication date	Nov 24, 2016
Grant date	—

Abstract

Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

First claim

1 - 41 . (canceled)

42 . A method for reducing or alleviating dry mouth comprising delivering an oral composition to an oral cavity in a subject, wherein the oral composition comprises:
a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound and a pharmaceutically acceptable carrier.

43 . The method of claim 42 , further comprising mixing the first component and the second component prior to delivering the oral composition to the oral cavity in the subject.

44 . The method of claim 42 , wherein the at least one E h -raising compound is selected from the group consisting of hydrogen peroxide, sodium chlorite, and a fermentable sugar; and
the at least one zinc compound is selected from the group consisting of zinc chloride and zinc acetate.

45 . The method of claim 44 , wherein the at least one E h -raising compound is sodium chlorite.

46 . The method of claim 42 , wherein the first component, the second component, or both comprise a humectant selected from the group consisting of glycerin, propylene glycol, hydrogenated glucose syrup, polyethylene glycol, propylene glycol, glycerol, erythritol, xylitol, sorbitol, mannitol, lactitol, and hydrogenated starch hydrolyzates.

47 . The method of claim 46 , wherein the humectant is sorbitol.

48 . The method of claim 42 , wherein the at least one E h -raising compound is selected from the group consisting of an oxyhalogen compound and hydrogen peroxide, and wherein the first composition further comprises a chlorine-containing compound selected from the group consisting of an alkali metal chloride salt, an alkaline earth metal chloride salt, and a combination thereof; and
wherein the first component comprises about 0.5% by weight to about 2.5% by weight of the chlorine-containing compound, and the second component comprises about 0.02% by weight to about 1.0% by weight of zinc compound.

49 . A method for treating or ameliorating a canker sore in a subject in need thereof, comprising delivering an oral composition to an oral cavity in the subject, wherein the oral composition comprises:
a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier; and a second component comprising at least one zinc compound and a pharmaceutically acceptable carrier.

50 . The method of claim 49 , further comprising mixing the first component and the second component prior to delivering the oral composition to the oral cavity in the subject.

51 . The method of claim 49 , wherein the at least one E h -raising compound is selected from the group consisting of hydrogen peroxide, sodium chlorite, and a fermentable sugar; and
the at least one zinc compound is selected from the group consisting of zinc chloride and zinc acetate.

52 . The method of claim 51 , wherein the at least one E h -raising compound is sodium chlorite.

53 . The method of claim 49 , wherein the at least one E h -raising compound is selected from the group consisting of an oxyhalogen compound and hydrogen peroxide, and wherein the first composition further comprises a chlorine-containing compound selected from the group consisting of an alkali metal chloride salt, an alkaline earth metal chloride salt, and a combination thereof; and
wherein the first component comprises about 0.5% by weight to about 2.5% by weight of the chlorine-containing compound, and the second component comprises about 0.02% by weight to about 1.0% by weight of zinc compound.

54 . A method for treating or ameliorating tooth decay in a subject in need thereof, comprising delivering an oral composition to an oral cavity in the subject, wherein the oral composition comprises:
a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier; and a second component comprising at least one zinc compound and a pharmaceutically acceptable carrier.

55 . The method of claim 54 , further comprising mixing the first component and the second component prior to delivering the oral composition to the oral cavity in the subject.

56 . The method of claim 54 , wherein the at least one E h -raising compound is selected from the group consisting of hydrogen peroxide, sodium chlorite, and a fermentable sugar; and
the at least one zinc compound is selected from the group consisting of zinc chloride and zinc acetate.

57 . The method of claim 56 , wherein the at least one E h -raising compound is sodium chlorite.

58 . The method of claim 54 , wherein the at least one E h -raising compound is selected from the group consisting of an oxyhalogen compound and hydrogen peroxide, and wherein the first composition further comprises a chlorine-containing compound selected from the group consisting of an alkali metal chloride salt, an alkaline earth metal chloride salt, and a combination thereof; and
wherein the first component comprises about 0.5% by weight to about 2.5% by weight of the chlorine-containing compound, and the second component comprises about 0.02% by weight to about 1.0% by weight of zinc compound.

59 . A method for polishing teeth in a subject in need thereof, comprising delivering an oral composition to an oral cavity in the subject, wherein the oral composition comprises:
a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier; and a second component comprising at least one zinc compound and a pharmaceutically acceptable carrier.

60 . A method for treating oral malodor in a non-human animal, comprising delivering an oral composition to an oral cavity of the non-human animal, wherein the oral composition comprises:
a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier; and a second component comprising at least one zinc compound and a pharmaceutically acceptable carrier.

61 . An oral composition comprising:
a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier; a second component comprising at least one zinc compound and a pharmaceutically acceptable carrier; and
an anti-inflammatory agent.

Assignees

• Univ New York State Res Found

Inventors

• Cohen Marvin
• Cohen Susanne
• Flynn Robert G

Classifications

• A61K8/27 Primary

  Zinc; Compounds thereof · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K9/0063

  Periodont · CPC title

• A61K8/922

  of vegetable origin · CPC title

• A61K2800/882

  Mixing prior to application · CPC title