Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
US-9493823-B2 · Nov 15, 2016 · US
Non-fouling polymeric surface modification and signal amplification method for biomolecular detection
US2016333392A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016333392-A1 |
| Application number | US-201615218625-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jul 25, 2016 |
| Priority date | Sep 15, 2005 |
| Publication date | Nov 17, 2016 |
| Grant date | — |
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Abstract
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An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) coupled to the brush molecules. The polymer layer is preferably formed by the process of surface-initiated polymerization (SIP) of monomeric units thereon. Preferably, each of the monomeric units comprises a monomer (for example, a vinyl monomer) core group having at least one protein-resistant head group coupled thereto, to thereby form the brush molecule on the surface portion. Methods of using the articles are also described.
First claim
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1 . A biomolecular detector, comprising: (a) a substrate having a surface portion; (b) a linking layer on said surface portion; and (c) a polymer layer formed on said linking layer by the process of surface-initiated polymerization of monomeric units thereon, with each of said monomeric units comprising a monomer core group having at least one protein-resistant head group coupled thereto, to thereby form a brush molecule on said surface portion; said brush molecule comprising a stem formed from the polymerization of said monomer core groups, and a plurality of branches formed from said head group projecting from said stem; and (d) a first member of a specific binding pair coupled to said brush molecule. 2 - 42 . (canceled)
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Classifications
- B01J19/0046Primary
Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays (synthesis methods per se C40B50/00) · CPC title
Nucleotides · CPC title
using probe arrays or probe chips (C12Q1/6874 takes precedence) · CPC title
The surface being organic · CPC title
by coating it with another layer · CPC title
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- What does patent US2016333392A1 cover?
- An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc…
- Who is the assignee on this patent?
- Univ Duke
- What technology area does this patent fall under?
- Primary CPC classification B01J19/0046. Mapped technology areas include Operations & Transport.
- When was this patent published?
- Publication date Thu Nov 17 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).