Attenuation of encrustation of medical devices using coatings of inorganic fullerene-like nanoparticles

Patent metadata

Field	Value
Publication number	US-2016331874-A1
Application number	US-201515109822-A
Country	US
Kind code	A1
Filing date	Jan 6, 2015
Priority date	Jan 6, 2014
Publication date	Nov 17, 2016
Grant date	—

Abstract

A new approach is presented to reduce encrustation of catheters by the application of nanoparticles. It is demonstrated that the negatively surface charged nanoparticles produce coating films comprised of long-range domains in which the nanoparticles are self-assembled into a mosaic-like order, showing a relatively small tendency to agglomerate.

First claim

1 . (canceled)

2 . An implantable or insertable medical device, coated on at least one surface region thereof with a film, said film consisting of inorganic fullerene-like nanoparticles (IF nanoparticles), or inorganic nanotubes (INT), and wherein said at least one surface region of the device is intended for direct contact with at least one inner-body tissue of a subject's body.

3 . (canceled)

4 . (canceled)

5 . An implantable medical device configured to be implanted in a subject, the device comprising an implantable unit or structure, wherein at least a surface region of said unit or structure being coated with a film of IF-nanoparticles adapted to prevent or inhibit deposition of encrustation and/or formation of a biofilm thereon after implantation in the subject.

6 . The medical device of claim 2 , being selected amongst devices used in diagnosis or in a medical procedure and which residence in the body of the patient increases susceptibility to growth and attachment of adventitious materials or exudates, or to result in the formation of biofilms.

7 . The medical device of claim 2 , being a device used in diagnosis or treatment of any pathological and non-pathological condition.

8 . The medical device according to claim 7 , wherein said condition is associated with a tissue, a gland, a tumor, a cyst, a muscle, a fascia, a skin region, an adipose, a mucous membrane, or any one organ being damaged or diseased, enlarged beyond its normal size, or stretched, obstructed, occluded, or collapsed of or from an adjacent body lumen or anatomical structure.

9 . The medical device of claim 2 , for bridging between two or more body organs, lumens or tissues.

10 . The medical device of claim 2 , being implanted for periods of between days and months to years in a recipient.

11 . The medical device of claim 2 , the medical device being an endoprosthesis.

12 . The medical device according to claim 11 , being selected from stents; catheters; dialysis tubes; cannulas; and sutures.

13 . The medical device of claim 2 , the medical device being a hollow device for inserting through a body opening or through the skin into a body cavity, duct, or vessel.

14 . The medical device of claim 2 , the medical device being a ureteral or urethral stent or catheter.

15 . The medical device of claim 2 , wherein the nanoparticles being of the general formula ML n , wherein M is a transition metal, L is a chalcogen and n is the number of chalcogen atoms L per each atom of the transition metal M.

16 . The medical device according to claim 15 , wherein the transition metal being selected from Sn, In, Ga, Bi, Mo, W, V, Zr, Hf, Pt, Pd, Re, Nb, Ta, Ti, Cr and Ru.

17 . The medical device according to claim 15 , wherein the chalcogene atom is selected from S, Se and Te.

18 . The medical device of claim 2 , wherein the inorganic nanoparticles being of the general formula A 1-x -B x -chalcognide, wherein A is a metal or a transition metal or an alloy of such a metal/transition metal, B is a metal or a transition metal, and x being ≦0.3 and different from zero, provided that: A≠B.

19 . The medical device according to claim 18 , wherein x is below 0.01, or below 0.005.

20 . The medical device according to claim 19 , wherein x is between 0.005 and 0.01.

21 . The medical device according to claim 18 , wherein A is a metal or transition metal or an alloy of metals or transition metals selected from Mo, W, Re, Ti, Zr, Hf, Nb, Ta, Pt, Ru, Rh, In, Ga, WMo, and TiW.

22 . The medical device according to claim 18 , wherein B is a metal or transition metal selected from Si, Nb, Ta, W, Mo, Sc, Y, La, Hf, Ir, Mn, Ru, Re, Os, V, Au, Rh, Pd, Cr, Co, Fe and Ni.

23 . The medical device according to claim 15 , wherein the nanoparticles are selected from TiS 2 , TiSe 2 , TiTe 2 , WS 2 , WSe 2 , WTe 2 , MoS 2 , MoSe 2 , MoTe 2 , SnS 2 , SnSe 2 , SnTe 2 , RuS 2 , RuSe 2 , RuTe 2 , GaS, GaSe, GaTe, InS, InSe, HfS 2 , ZrS 2 , VS 2 , ReS 2 and NbS 2 .

24 . The medical device according to claim 23 , wherein the nanoparticles are selected from WS 2 and MoS 2 .

25 . The medical device according to claim 21 , wherein the nanoparticles are selected from WS 2 and MoS 2 and are doped with Re or Nb.

26 . The medical device according to claim 21 , wherein the metal chalcogenide nanostructures of the formula A 1-x B x -chalcogenide are selected from W 1-x B x -chalcogenide, Mo 1-x B x -chalcogenide, Nb 1-x B x -chalcogenide and Ta 1-x B x -chalcogenide.

27 . (canceled)

28 . The medical device according to claim 26 , wherein the nanoparticles are doped with dopant atoms B selected from atoms Si, Nb, Ta, W, Mo, Sc, Y, La, Hf, Ir, Mn, Ru, Re, Os, V, Au, Rh, Pd, Cr, Co, Fe and Ni.

29 . A process for reducing, diminishing or preventing the formation of encrustations on a surface region of an implantable medical device, the process comprising forming a coating or a film of IF-nanoparticles on said surface region prior to implanting or inserting said device into a body tissue, organ or body lumen.

Assignees

• Yeda Res & Dev
• Mor Research Applic Ltd

Inventors

• Tenne Reshef
• Zbaida David
• Ron Racheli
• Kafka Ilan
• Leibovitz Ilan

Classifications

• A61L31/14

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L31/088 Primary

  Other specific inorganic materials not covered by A61L31/084 or A61L31/086 · CPC title

• A61L29/14

  Materials characterised by their function or physical properties {, e.g. lubricating compositions} · CPC title

• A61L2420/02

  Methods for coating medical devices · CPC title

• A61L29/106

  Inorganic materials other than carbon · CPC title