Medical Devices Containing Nitroprusside and Antimicrobial Agents

Patent metadata

Field	Value
Publication number	US-2016331871-A1
Application number	US-201615219829-A
Country	US
Kind code	A1
Filing date	Jul 26, 2016
Priority date	Mar 11, 2009
Publication date	Nov 17, 2016
Grant date	—

Abstract

A medical device includes a structure configured for introduction to a vascular system of a patient. The structure including a surface having sodium nitroprusside and silver disposed thereupon. The sodium nitroprusside has a concentration sufficient to reduce thrombosis. To make the medical device, a base material is impregnated with sodium nitroprusside, the medical device is formed from the base material, and the medical device is coated with an antimicrobial agent.

First claim

What is claimed is:

1 . A vascular catheter comprising:
a polymer base having a bulk distribution of sodium nitroprusside (SNP) in a range between 0.1% weight/weight (w/w) to 10% w/w; and a coating disposed on the polymer base, wherein the coating includes an antimicrobial agent and the antimicrobial agent is a biguanide.

2 . The vascular catheter according to claim 1 , wherein the biguanide is present in the coating in a range between 0.5%-10% w/w.

3 . The vascular catheter according to claim 2 , wherein the biguanide is present in the coating in a range between 2%-6% w/w.

4 . The vascular catheter according to claim 1 , wherein the antimicrobial agent includes chlorhexidine base and/or a pharmaceutically acceptable salt thereof.

5 . The vascular catheter according to claim 4 , wherein the antimicrobial agent includes chlorhexidine diacetate.

6 . The vascular catheter according to claim 4 , wherein the antimicrobial agent includes chlorhexidine dodecanoate.

7 . The vascular catheter according to claim 4 , wherein the antimicrobial agent includes chlorhexidine palmitate.

8 . The venous catheter according to claim 1 , wherein the SNP is present in the polymer base in a range between 1% w/w to 5% w/w.

9 . The vascular catheter according to claim 1 , wherein the coating includes:
polytetrahydrofuran (THF) in a range between 60% and 97% w/w; methanol in a range between 40%-3% volume/weight (v/w); and polyurethane in a range between 0% and 10% (w/w).

10 . The vascular catheter according to claim 1 , wherein the polymer base is a polyurethane material selected from the group consisting of polyether urethane, polyester urethane, and polycarbonate urethane, and Polydimethylsiloxane urethane copolymers (PDMS) urethane.

11 . The vascular catheter according to claim 1 , wherein the antimicrobial agent is an alexidine salt including one or more of Alexidine dihydrochloride and Alexidine diacetate.

12 . The vascular catheter according to claim 1 , wherein the coating is disposed both internally within the vascular catheter and externally on the vascular catheter.

13 . A tubular medical device comprising:
a polymer base having a bulk distribution of sodium nitroprusside (SNP) in a range between 0.1% weight/weight (w/w) to 10% w/w; and a coating disposed on the polymer base, wherein the coating includes an antimicrobial agent and the antimicrobial agent is a biguanide.

14 . The tubular medical device according to claim 13 , wherein the biguanide is present in the coating in a range between 0.5%-10% w/w.

15 . The tubular medical device according to claim 14 , wherein the biguanide is present in the coating in a range between 2%-6% w/w.

16 . The tubular medical device according to claim 13 , wherein the antimicrobial agent includes chlorhexidine base and/or a pharmaceutically acceptable salt thereof.

17 . The tubular medical device according to claim 16 , wherein the antimicrobial agent includes chlorhexidine diacetate.

18 . The tubular medical device according to claim 16 , wherein the antimicrobial agent includes chlorhexidine dodecanoate.

19 . The tubular medical device according to claim 16 , wherein the antimicrobial agent includes chlorhexidine palmitate.

20 . The tubular medical device according to claim 13 , wherein the SNP is present in the polymer base in a range between 1% w/w to 5% w/w.

21 . The tubular medical device according to claim 13 , wherein the coating includes:
polytetrahydrofuran (THF) in a range between 60% and 97% w/w; methanol in a range between 40%-3% volume/weight (v/w); and polyurethane in a range between 0% and 10% (w/w).

22 . The tubular medical device according to claim 13 , wherein the polymer base is a polyurethane material selected from the group consisting of polyether urethane, polyester urethane, and polycarbonate urethane, and Polydimethylsiloxane urethane copolymers (PDMS) urethane.

23 . The tubular medical device according to claim 13 , wherein the antimicrobial agent is an alexidine salt including one or more of Alexidine dihydrochloride and Alexidine diacetate.

24 . The tubular medical device according to claim 13 , wherein the coating is disposed both internally within the tubular medical device and externally on the tubular medical device.

Assignees

• Teleflex Medical Inc

Inventors

• Gupta Nisha
• Rosenblatt Joel
• Steinke Elaine

Classifications

• A61L2103/15

  Laboratory, medical or dentistry appliances, e.g. catheters or sharps · CPC title

• A61L29/16 Primary

  Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)} · CPC title

• A61L2300/404

  Biocides, antimicrobial agents, antiseptic agents · CPC title

• A61L2300/42

  Anti-thrombotic agents, anticoagulants, anti-platelet agents · CPC title

• A61L29/085

  Macromolecular materials · CPC title