Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same

Patent metadata

Field	Value
Publication number	US-2016331869-A1
Application number	US-201615220727-A
Country	US
Kind code	A1
Filing date	Jul 27, 2016
Priority date	Sep 9, 2005
Publication date	Nov 17, 2016
Grant date	—

Abstract

A method of treating bone deficiencies includes applying a biocompatible structure to an implant surgical site. The biocompatible structure includes multiple polymer layers stacked to have a predetermined shape, multiple bone particle layers disposed between each of two neighboring polymer layers of the multiple polymer layers, and a coating surrounding the polymer layers and bone particle layers. Each of the polymer layers is formed with a polymer and first tissue forming nanoparticles. The predetermined shape is configured to conform to the implant surgical site.

First claim

What is claimed is:

1 . A method of treating bone deficiencies, comprising applying a biocompatible structure to an implant surgical site, wherein the biocompatible structure comprises:
a plurality of polymer layers stacked to have a predetermined shape, wherein each of the polymer layers is formed with a polymer and first tissue forming nanoparticles; a plurality of bone particle layers disposed between each of two neighboring polymer layers of the plurality of polymer layers; and a coating surrounding the plurality of polymer layers and bone particle layers.

2 . The method of claim 1 , wherein the predetermined shape is configured to conform to the implant surgical site.

3 . The method of claim 1 , wherein a weight percentage of the first tissue forming nanoparticles to the polymer is about 0.05-95% such that a resorption rate of the biocompatible structure substantially matches a rate of tissue generation in the biocompatible structure.

4 . The method of claim 3 , wherein the weight percentage of the first tissue forming nanoparticles to the polymer is about 20%.

5 . The method of claim 3 , wherein the weight percentage of the first tissue forming nanoparticles to the polymer is about 25%.

6 . The method of claim 1 ,
wherein the polymer comprises a synthetic biodegradable polymer, a biodegradable polymer from a natural source, or a mixture thereof; and wherein the synthetic biodegradable polymer comprises polyurethane, polylactide (PLA), polyglycolide (PGA), poly(lactide-co-glycolide) (PLGA), poly(e-caprolactone), polydioxanone, polyanhydride, trimethylene carbonate, poly(β-hydroxybutyrate), poly(g-ethyl glutamate), poly(desaminotyrosyl-tyrosine-hexyl ester (DTH)iminocarbonate), poly(bisphenol A iminocarbonate), poly(ortho ester), polycyanoacrylate, polyphosphazene, or a mixture thereof.

7 . The method of claim 1 , wherein the first tissue forming nanoparticles comprise nanoparticles of hydroxypatites, tricalcium phosphates, mixed calcium phosphates and calcium carbonate, bone particles of zenograft, bone particles of allografts, bone particles of autografts, bone particles of alloplastic grafts, or a mixture thereof.

8 . The method of claim 1 , wherein the biocompatible structure further comprises a plurality of second tissue forming particles attached to an outer surface of the coating.

9 . The method of claim 8 , wherein the biocompatible structure is formed by:
dissolving the polymer in a solvent to form a first solution; adding the first tissue forming nanoparticles to the first solution to form a second solution wherein a weight percentage of the first tissue forming nanoparticles to the polymer is about 0.01-95%; applying the second solution to a surface to form a polymer film on the surface, wherein the first tissue forming nanoparticles are dispersed in the polymer film; dividing the polymer film into strips; constructing a scaffold by stacking the strips to form polymer layers and adding bone or composite particles between the polymer layers; applying the second solution to the scaffold to form the coat layer surrounding the scaffold; and adding the second tissue forming particles to the coat layer to form a second tissue forming particle layer surrounding the coat layer, so as to obtain the biocompatible structure.

10 . The method of claim 9 , wherein the biocompatible structure is further formed by, after adding the second tissue forming particles to the coat layer, plasma treating the-scaffold surrounded with the coat layer and the second tissue forming particle layer.

11 . The method of claim 9 , wherein the surface is a polytetrafluoroethylene (PTFE) surface.

12 . The method of claim 9 , wherein the second tissue forming particles comprise nano-sized bone particles, micro-sized bone particles, or a mixture thereof.

13 . The method of claim 9 , wherein each of the strips has a length of about 0.005-50 centimeter, a width of about 0.002-50 centimeter, and a thickness of about 0.001-500 millimeter, and the biocompatible structure is in a cylindrical shape or a spherical shape.

12 . The method of claim 9 , wherein the biocompatible structure is further formed by, adding a third tissue forming material to the biocompatible structure,
wherein the third tissue forming material comprises a bioactive material, cells, or a mixture thereof; wherein the bioactive material comprises proteins, enzymes, growth factors, amino acids, bone morphogenic proteins, platelet derived growth factors, vascular endothelial growth factors, or a mixture thereof; and wherein the cells comprises epithelial cells, neurons, glial cells, astrocytes, podocytes, mammary epithelial cells, islet cells, endothelial cells, mesenchymal cells, stem cells, osteoblast, muscle cells, striated muscle cells, fibroblasts, hepatocytes, ligament fibroblasts, tendon fibroblasts, chondrocytes, or a mixture thereof.

Assignees

• Univ Arkansas

Inventors

• Biris Alexandru S

Classifications

• A61L27/58 Primary

  Materials at least partially resorbable by the body · CPC title

• A61L2300/414

  Growth factors · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61F2/2846

  Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects (nets or sleeves applied to surface of endoprostheses A61F2/30907; bone plates A61B17/80; bone regeneration in dental surgery A61C8/0006) · CPC title

• A61L27/365

  Bones · CPC title