Fullerene compounds as antioxidant therapy

Patent metadata

Field	Value
Publication number	US-2016331698-A1
Application number	US-201515111331-A
Country	US
Kind code	A1
Filing date	Jan 13, 2015
Priority date	Jan 13, 2014
Publication date	Nov 17, 2016
Grant date	—

Abstract

Disclosed herein are small-gap fullerene compositions and methods of using for therapeutic or cosmetic purposes. Specifically exemplified is the use of derivatized SGFs so as to be water-soluble. The derivatized SGFs include polyhydroxylated and polycarboxylated SGFs.

First claim

What is claimed is:

1 . A method of treating or preventing an unwanted condition, disease or symptom of a patient associated with oxidative stress comprising administering a therapeutically effective amount or prophylactically effective amount of a small-gap fullerene (SGF) composition to a subject in need.

2 . The method of claim 1 , wherein said SGF composition comprises SGF compounds ranging from a size of C 60 to C 400 .

3 . The method of claim 1 , wherein the SGF composition comprises SGFs with at least fifty percent being water-soluble SGFs.

4 . The method of claim 3 , wherein the water-soluble SGFs comprise polyhydroxylate SGFs (PSGFs) or polycarboxylated SGFs.

5 . The method of claim 2 , wherein said SGF composition comprises a peak distribution of SGF compounds of a size between about C 100 to C 200 .

6 . The method of claim 5 , wherein said peak distribution comprises SGF compounds of a size of about C 120 .

7 . The method of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.

8 . The method of claim 1 , wherein the oxidative stress is associated with Abeta.

9 . The method of claim 1 , wherein the unwanted condition is a neurodegenerative disease.

10 . The method of claim 9 , wherein the neurodegenerative disease is Alzheimer's disease, Parkinson's disease, or Dementia with Lewy Bodies.

11 . A method for improving the general condition and appearance of skin, the method comprising administering a cosmetically effective amount of a SGF composition to a patient for cosmetic purposes.

12 . The method of claim 11 , wherein said SGF composition is administered topically.

13 . The method of claim 11 , wherein said method diminishes the appearance of wrinkles.

14 . The method of claim 11 , wherein said SGF composition comprises SGF compounds ranging from a size of C 60 to C 400 .

15 . The method of claim 11 , wherein the SGF composition comprises SGFs with at least fifty percent being water-soluble SGFs.

16 . The method of claim 15 , wherein the water-soluble SGFs comprise polyhydroxylate SGFs (PSGFs) or polycarboxylated SGFs.

17 . The method of claim 11 , wherein said SGF composition comprises a peak distribution of SGF compounds of a size between about C 100 to C 200 .

18 . A composition formulated for topical administration, said composition comprising SGFs and cosmetically acceptable carrier.

19 . The composition of claim 18 , further comprising at least one conjunctive agent.

20 . The composition of claim 19 , wherein said conjunctive agent comprises sun blocking agents, acute or chronic moisturizing agents, anti-oxidants, sunscreens having UVA and/or UVB protection, emollients, anti-irritants, vitamins, trace metals, anti-microbial agents, botanical extracts, fragrances, dyes and color ingredients, structuring agents, and/or emulsifiers

21 . The composition of claim 18 , wherein SGFs comprises at least 50 percent PSGFs.

Assignees

• Sugaya Kiminobu
• Torres Alexander
• Univ Central Florida Res Found Inc

Inventors

• Sugaya Kiminobu
• Torres Alexander

Classifications

• A61P39/06

  Free radical scavengers or antioxidants · CPC title

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61P25/16

  Anti-Parkinson drugs · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61P17/16

  Emollients or protectives, e.g. against radiation · CPC title