Methods and systems for manufacturing a tablet

Patent metadata

Field	Value
Publication number	US-2016319464-A1
Application number	US-201514701218-A
Country	US
Kind code	A1
Filing date	Apr 30, 2015
Priority date	Apr 30, 2015
Publication date	Nov 3, 2016
Grant date	—

Abstract

Methods and systems for manufacturing a tablet are generally provided. Certain embodiments comprise electrodepositing (e.g., electrospinning) a material (e.g., the tablet material, for example, within a fluid) onto a substrate. The substrate can be, for example, an elongated rod. In some such embodiments, after material has been electrodeposited onto the substrate, a die comprising a cavity and the substrate can be moved relative to each other such that the electrodeposited material is at least partially stripped from the substrate and/or at least partially deposited into the cavity of the die. Some embodiments comprise compressing the material in the cavity to form a tablet.

First claim

What is claimed is:

1 . An electrodeposition system for manufacturing a tablet, comprising:
a substrate having a first electric potential; a source configured to contain a fluid, the source having a second electric potential different than the first electric potential; an emitter associated with the source and configured to emit fluid contained within the source toward the substrate; a die comprising a cavity, the die configured to strip material from an exterior surface of the substrate when the die and the substrate are moved relative to each other; and an actuator associated with the substrate and/or the die and configured to move the die and the substrate relative to each other.

2 . A system for manufacturing a tablet, comprising:
a substrate; a source configured to support a fluid, the source facing the substrate; a die comprising a cavity; and an actuator associated with the substrate and/or the die and configured to move the die and the substrate relative to each other.

3 . A system as in claim 1 , wherein the substrate comprises an elongated rod.

4 . A system as in claim 1 , wherein the substrate can be rotated.

5 . A system as in claim 1 , comprising a compacting die that fits into the die and a compaction actuator.

6 . A system as in claim 2 , wherein the substrate has a first electric potential.

7 . A system as in claim 6 , wherein the source has a second electric potential, wherein the second electric potential is different than the first electric potential.

8 . A system as in claim 1 , wherein the system comprises an electric potential generator electrically connected to the substrate and the source.

9 . A system as in claim 1 , wherein the source is electrically isolated from the substrate.

10 . A system as in claim 1 , wherein the substrate is connected to an electrical ground.

11 . A system as in claim 1 , wherein the system comprises a second actuator associated with a plunger and/or the die and configured to move the plunger and the die relative to each other.

12 . A system as in claim 11 , wherein the second actuator is configured to move the plunger and the die relative to each other such that at least a portion of the plunger is inserted into the cavity.

13 . A system as in claim 1 , wherein the substrate has an exterior surface comprising protrusions.

14 . A system as in claim 13 , wherein the protrusions of the exterior surface of the substrate are configured to mate with protrusions on an exposed surface of the die.

15 . A system as in claim 13 , wherein the protrusions of the exterior surface of the substrate are substantially helical.

16 . A system as in claim 1 , wherein the source comprises a reservoir.

17 . A system as in claim 1 , wherein the source comprises a mixing rod.

18 . A method for manufacturing a tablet, comprising:
electrospinning a material on a rotating substrate such that the material accumulates on the substrate while it is rotated; moving a die comprising a cavity and the substrate relative to each other such that at least a portion of the accumulated material is stripped from the substrate into the cavity of the die; and applying a compressive force to the accumulated material within the cavity of the die to form the tablet.

19 - 20 . (canceled)

21 . A method as in claim 18 , wherein the substrate comprises an elongated rod.

22 . A method as in claim 18 , wherein the method comprises removing at least a portion of the electrodeposited material from the substrate.

23 - 32 . (canceled)

Assignees

• Massachusetts Inst Technology

Inventors

• Slocum Alexander H
• Sondej Nicholas M
• Trout Bernhardt Levy
• Rutledge Gregory C
• Bhattacharyya Indrani

Classifications

• A61J3/00

  Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms · CPC title

• A61J3/10

  into the form of compressed tablets (tablet presses B30B11/00) · CPC title

• A61K9/2095

  Tabletting processes · CPC title

• B05B5/025

  Discharge apparatus, e.g. electrostatic spray guns · CPC title

• D01D5/0076 Primary

  characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid (D01D5/0046 takes precedence) · CPC title