Passive immunization for staphylococcus infections

US2016311925A1 · US · A1

Patent metadata
FieldValue
Publication numberUS-2016311925-A1
Application numberUS-201415104104-A
CountryUS
Kind codeA1
Filing dateDec 15, 2014
Priority dateDec 13, 2013
Publication dateOct 27, 2016
Grant date

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  2. Abstract

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Abstract

Official abstract text for this publication.

Disclosed herein are monoclonal antibodies or binding portion thereof that bind specifically to a Staphylococcus spp. autolysin N-acetylmuramoyl-L-alanine amidase catalytic domain and/or cell wall binding domain, as well as pharmaceutical compositions containing the same. Cell lines expressing the monoclonal antibodies, including hybridomas, are also disclosed. Methods of using the monoclonal antibodies for installation of orthopedic implants, grafts or medical devices, treating or preventing a Staphylococcus infection, and treating osteomyelitis are described, as are diagnostic methods for the detection of Staphylococcus in a sample.

First claim

Opening claim text (preview).

What is claimed is: 1 . A monoclonal antibody, or binding portion thereof, that binds specifically to a Staphylococcus spp. autolysin consensus N-acetylmuramoyl-L-alanine amidase (Amd) catalytic domain and/or cell wall binding domain. 2 . The monoclonal antibody, or Amd binding portion thereof, according to claim 1 , wherein the monoclonal antibody or Amd binding portion inhibits in vivo growth of a Staphylococcus strain and/or biofilm establishment on…

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What does patent US2016311925A1 cover?
Disclosed herein are monoclonal antibodies or binding portion thereof that bind specifically to a Staphylococcus spp. autolysin N-acetylmuramoyl-L-alanine amidase catalytic domain and/or cell wall binding domain, as well as pharmaceutical compositions containing the same. Cell lines expressing the monoclonal antibodies, including hybridomas, are also disclosed. Methods of using the monoclonal…
Who is the assignee on this patent?
Univ Rochester
What technology area does this patent fall under?
Primary CPC classification C07K16/40. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Thu Oct 27 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).