Methods and materials for identifying and treating membranous nephropathy
US-2024353404-A1 · Oct 24, 2024 · US
US2016311925A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016311925-A1 |
| Application number | US-201415104104-A |
| Country | US |
| Kind code | A1 |
| Filing date | Dec 15, 2014 |
| Priority date | Dec 13, 2013 |
| Publication date | Oct 27, 2016 |
| Grant date | — |
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Disclosed herein are monoclonal antibodies or binding portion thereof that bind specifically to a Staphylococcus spp. autolysin N-acetylmuramoyl-L-alanine amidase catalytic domain and/or cell wall binding domain, as well as pharmaceutical compositions containing the same. Cell lines expressing the monoclonal antibodies, including hybridomas, are also disclosed. Methods of using the monoclonal antibodies for installation of orthopedic implants, grafts or medical devices, treating or preventing a Staphylococcus infection, and treating osteomyelitis are described, as are diagnostic methods for the detection of Staphylococcus in a sample.
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What is claimed is: 1 . A monoclonal antibody, or binding portion thereof, that binds specifically to a Staphylococcus spp. autolysin consensus N-acetylmuramoyl-L-alanine amidase (Amd) catalytic domain and/or cell wall binding domain. 2 . The monoclonal antibody, or Amd binding portion thereof, according to claim 1 , wherein the monoclonal antibody or Amd binding portion inhibits in vivo growth of a Staphylococcus strain and/or biofilm establishment on…
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
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