Balloon coating method, balloon rotating method and balloon coating apparatus

Patent metadata

Field	Value
Publication number	US-2016310709-A1
Application number	US-201615136397-A
Country	US
Kind code	A1
Filing date	Apr 22, 2016
Priority date	Apr 23, 2015
Publication date	Oct 27, 2016
Grant date	—

Abstract

A balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter includes: fixing a connection portion between the balloon and an inner tube penetrating an inside of the balloon in such a manner as to clamp the connection portion by at least two clamping portions each having a groove-shaped curved surface extending along an axis of the inner tube; pulling the balloon in an axial direction of the balloon by the clamping portions to thereby straighten a bend of the balloon; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in the axial direction of the balloon, while rotating the balloon about an axis of the balloon, to thereby coat the outer surface of the balloon with the coating liquid.

First claim

What is claimed is:

1 . A balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter, the balloon coating method comprising:
fixing a connection portion between the balloon and an inner tube passing through an inside of the balloon by clamping the connection portion with at least two clamping portions each including a groove-shaped curved surface extending along an axis of the inner tube; pulling the balloon in an axial direction of the balloon by the clamping portions to thereby straighten a bend of the balloon; and moving a dispensing tube relative to the balloon in an axial direction of the balloon while rotating the balloon about an axis of the balloon and while also dispensing the coating liquid containing the water-insoluble drug from the dispensing tube to apply the coating liquid to the outer surface of the balloon.

2 . The balloon coating method according to claim 1 , further comprising rotating the balloon while, dispensing the coating liquid from the dispensing tube and while pulling the balloon in the axial direction of the balloon by the clamping portions.

3 . The balloon coating method according to claim 1 , wherein the at least two clamping portions are provided in a collet chuck.

4 . The balloon coating method according to claim 1 , wherein each of the at least two clamping portions possesses a tapered outer surface, the at least two clamping portions being positioned in a holder possessing a tapered inner surface, and the clamping of the connection portion with the at least two clamping portions comprising relatively moving the holder and the at least two clamping portions so that the tapered outer surfaces of the at least two clamping portions contact and move along the tapered inner surface of the holder to cause the at least two clamping portions to move inwardly towards the connection portion.

5 . The balloon coating method according to claim 1 , wherein the at least two clamping portions are connected to a motor, the pulling of the balloon in the axial direction of the balloon comprising axially moving the motor.

6 . The balloon coating method according to claim 5 , wherein the rotating of the balloon about the axis of the balloon includes rotating the at least two clamping portions through operation of the motor.

7 . The balloon coating method according to claim 1 , wherein the at least two clamping portions are connected to a motor, and the rotating of the balloon about the axis of the balloon includes rotating the at least two clamping portions through operation of the motor.

8 . A balloon rotating method for rotating a balloon catheter that includes a balloon possessing an axis and an inner tube passing through the balloon, the balloon possessing one end portion axially overlapping and connected in a fluid-tight manner to the inner tube at a connection portion, the balloon rotating method comprising:
clamping the connection portion by at least two clamping portions each including a groove-shaped curved surface extending along the axis of the inner tube; and rotating the balloon about the axis of the balloon while the connection portion is clamped by the clamping portions.

9 . The balloon rotating method according to claim 8 , further comprising pulling the balloon in an axial direction of the balloon by the clamping portions.

10 . The balloon rotating method according to claim 8 , wherein the at least two clamping portions are part of a collet chuck.

11 . The balloon rotating method according to claim 8 , wherein each of the at least two clamping portions possesses a tapered outer surface, the at least two clamping portions being positioned in a holder possessing a tapered inner surface, and the clamping of the connection portion with the at least two clamping portions comprising relatively moving the holder and the at least two clamping portions so that the tapered outer surfaces of the at least two clamping portions contact and move along the tapered inner surface of the holder to cause the at least two clamping portions to move inwardly towards the connection portion.

12 . The balloon rotating method according to claim 8 , wherein the at least two clamping portions are connected to a motor, the rotating of the balloon comprising rotating the balloon through operation of the motor.

13 . The balloon rotating method according to claim 12 , further comprising pulling the balloon in an axial direction of the balloon by axially moving the motor.

14 . A balloon coating apparatus configured to form a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter, the balloon coating apparatus comprising:
at least two clamping portions configured to fix, by way of clamping, a connection portion between the balloon and an inner tube penetrating an inside of the balloon, the clamping portions each including a groove-shaped curved surface extending along an axis of the inner tube; a rotation driving section configured to rotate the balloon catheter; and a coating section that moves a dispensing tube, configured to dispense the coating liquid containing the drug, relative to the balloon in an axial direction of the balloon to thereby coat the outer surface of the balloon with the coating liquid.

15 . The balloon coating apparatus according to claim 14 , further comprising:
a tension section that applies a tensile force for pulling the balloon in the axial direction of the balloon while allowing the balloon to rotate.

16 . The balloon coating apparatus according to claim 14 , wherein the at least two clamping portions are part of a collet chuck.

17 . The balloon coating apparatus according to claim 14 , wherein each of the at least two clamping portions possesses a tapered outer surface, the at least two clamping portions being positioned in a holder possessing a tapered inner surface that is contacted by the tapered outer surfaces of the at least two clamping portions as the at least two clamping portions are moved axially to move the at least two clamping portions inwardly towards the connection portion.

18 . The balloon coating apparatus according to claim 14 , wherein the rotation driving section includes a motor connected to the at least two clamping portions so that operation of the motor results in rotation of the at least two clamping portions.

19 . The balloon coating apparatus according to claim 18 , wherein the motor is one motor, and the rotation driving section including another motor connectable to a proximal end of the catheter balloon.

20 . The balloon coating apparatus according to claim 18 , wherein the motor is axially movably mounted on a base section to apply tension to the balloon by axially moving the motor away from the balloon catheter.

Assignees

• Terumo Corp

Inventors

• Gotou Hiroshi
• Kurosaki Yasuo
• FURUICHI Eisuke

Classifications

• B05C5/0216

  by relative movement of article and outlet according to a predetermined path · CPC title

• A61M2025/105

  having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes · CPC title

• B05C13/02

  for particular articles · CPC title

• A61M2025/1031

  Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface · CPC title

• A61M25/1029 Primary

  Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril · CPC title