Noninvasive imaging apparatus for gastrointestinal track

Patent metadata

Field	Value
Publication number	US-2016310106-A1
Application number	US-201615134732-A
Country	US
Kind code	A1
Filing date	Apr 21, 2016
Priority date	Apr 23, 2015
Publication date	Oct 27, 2016
Grant date	—

Abstract

Provided is a non-invasive imaging apparatus of acquiring an image of a region of interest of an object, including: a laser supplying a laser beam; a fiber bundle transmitting the laser beam to the region of interest of the object; a transducer detecting an ultrasound signal output from the region of interest of the object corresponding to the laser beam supplied from the fiber bundle and generating and outputting an ultrasound detection signal; and an ultrasound device generating and outputting a photoacoustic image by using the ultrasound detection signal output from the transducer, wherein the region of interest of the object is a gastrointestinal track of an animal, wherein the transducer detects the ultrasound signal of the gastrointestinal track of the animal into which a contrast agent is injected, and wherein the photoacoustic image is an image of the region of interest into which the contrast agent is injected.

First claim

What is claimed is:

1 . Anon-invasive imaging apparatus of acquiring an image of a region of interest of an object, comprising:
a laser which supplies a laser beam; a fiber bundle which transmits the laser beam to the region of interest of the object; a transducer which detects an ultrasound signal output from the region of interest of the object corresponding to the laser beam supplied from the fiber bundle and generates and outputs an ultrasound detection signal according to the detected ultrasound signal; and an ultrasound device which generates a photoacoustic image by using the ultrasound detection signal output from the transducer and outputs the photoacoustic image, wherein the region of interest of the object is a gastrointestinal track of an animal, wherein the transducer detects the ultrasound signal of the gastrointestinal track of the animal into which a contrast agent is injected, and wherein the photoacoustic image is an image of the region of interest into which the contrast agent is injected.

2 . The non-invasive imaging apparatus according to claim 1 , wherein the contrast agent is a naphthalocyanine nano structure.

3 . The non-invasive imaging apparatus according to claim 1 ,
wherein the fiber bundle is configured with first and second fiber bundles, wherein the laser beam supplied from the laser is split into two laser beams, and the two laser beams are supplied to the respective first and second fiber bundles, and wherein the first and second fiber bundles irradiate the region of interest of the object with the laser beams.

4 . The non-invasive imaging apparatus according to claim 1 ,
wherein the laser supplies the laser beam to the region of interest of the object and, simultaneously, supplies a trigger signal to the ultrasound device, and wherein the ultrasound device receives the ultrasound detection signal from the transducer according to the trigger signal and generates the photoacoustic image by using the received ultrasound detection signal.

5 . The non-invasive imaging apparatus according to claim 1 , further comprising a control device,
wherein the control device controls a movement of the fiber bundle and the transducer corresponding to a flow of the contrast agent existing in the gastrointestinal track of the animal which is the region of interest of the object, so that the transducer acquires the ultrasound signal at a position where the contrast agent exists.

6 . The non-invasive imaging apparatus according to claim 1 , wherein the ultrasound device allows the transducer to transmit an ultrasound signal to the region of interest of the object and receive the ultrasound signal returned from the object, generates and outputs the ultrasound image by using the ultrasound detection signal provided from the transducer corresponding to the ultrasound signal.

7 . The non-invasive imaging apparatus according to claim 1 , further comprising a control device,
wherein, if a first control command signal requiring the ultrasound image is input, the control device controls the ultrasound device to allow the transducer to transmit the ultrasound signal to the region of interest of the object and receive the ultrasound signal returned from the object, and the ultrasound device generates and outputs the ultrasound image by using the ultrasound detection signal received from the transducer corresponding to the ultrasound signal, and wherein, if a second control command signal requiring the photoacoustic image is input, the control device drives the laser to irradiate the region of interest of the object with the laser beam, the transducer detects the ultrasound signal output from the region of interest of the object according to the laser beam, and the ultrasound device generates and outputs the photoacoustic image by using the ultrasound detection signal received from the transducer.

8 . The non-invasive imaging apparatus according to claim 1 , wherein wavelength and intensity of the laser beam of the laser are variable according to a command input externally.

9 . Anon-invasive imaging apparatus of acquiring an image of a region of interest of an object, comprising:
a laser which supplies a laser beam; a fiber bundle which transmits the laser beam to the region of interest of the object; a transducer which detects an ultrasound signal output from the region of interest of the object corresponding to the laser beam supplied from the fiber bundle and generates and outputs an ultrasound detection signal; an ultrasound device which generates a photoacoustic image by using the ultrasound detection signal output from the transducer and outputs the photoacoustic image; and a control device which controls the laser and the ultrasound device according to a control command signal input externally to generate and output one of an ultrasound image and a photoacoustic image, wherein, if a first control command signal requiring the ultrasound image is input, the control device controls the ultrasound device to allow the transducer to transmit the ultrasound signal to the region of interest of the object and receive the ultrasound signal returned from the object, and the ultrasound device generates and outputs the ultrasound image by using the ultrasound detection signal received from the transducer corresponding to the ultrasound signal, and wherein, if a second control command signal requiring the photoacoustic image is input, the control device drives the laser to irradiate the region of interest of the object with the laser beam, the transducer detects the ultrasound signal output from the region of interest of the object according to the laser beam, and the ultrasound device generates and outputs the photoacoustic image by using the ultrasound detection signal received from the transducer.

10 . The non-invasive imaging apparatus according to claim 9 ,
wherein the region of interest of the object is a gastrointestinal track of an animal, wherein, if the second control command signal requiring the photoacoustic image is input, the control device controls the transducer to detect the ultrasound signal of the gastrointestinal track of the animal into which the contrast agent is injected, and wherein the photoacoustic image is the photoacoustic image of the region of interest into which the contrast agent is injected.

11 . The non-invasive imaging apparatus according to claim 10 , wherein the contrast agent is a naphthalocyanine nano structure.

12 . The non-invasive imaging apparatus according to claim 9 ,
wherein the fiber bundle is configured with first and second fiber bundles, wherein the laser beam supplied from the laser is split into two laser beams, and the two laser beams are supplied to the respective first and second fiber bundles, and wherein the first and second fiber bundles irradiate the region of interest of the object with the laser beams.

13 . The non-invasive imaging apparatus according to claim 9 ,
wherein the laser supplies the laser beam to the region of interest of the object and, simultaneously, supplies a trigger signal to the ultrasound device according to control of the control device, and wherein the ultrasound device receives the ultrasound detection signal from the transducer according to the trigger signal and generates the photoacoustic image by using the received ultrasound detection signal.

14 . The non-invasive imaging apparatus according to claim 10 , wherein the control device controls the movement of the fiber bundle and the transducer corresponding to a flow of the contrast agent existing in the gastrointestinal track of the animal wh

Assignees

• Postech Academy-Industry Found

Inventors

• Kim Chulhong
• Jeon Mansik
• Lee Changho
• Kim Jeesu

Classifications

• A61B5/0095 Primary

  by applying light and detecting acoustic waves, i.e. photoacoustic measurements · CPC title

• A61B8/08

  Clinical applications (A61B8/02, A61B8/04, A61B8/06 take precedence) · CPC title

• A61B8/5207

  involving processing of raw data to produce diagnostic data, e.g. for generating an image · CPC title

• A61B8/54

  Control of the diagnostic device · CPC title

• A61B8/481 Primary

  involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream · CPC title