An improved process for preparing Linagliptin and its key Intermediates

Patent metadata

Field	Value
Publication number	US-2016304520-A1
Application number	US-201414902257-A
Country	US
Kind code	A1
Filing date	Jul 8, 2014
Priority date	Jul 11, 2013
Publication date	Oct 20, 2016
Grant date	—

Abstract

The present invention relates to a process for the preparation of Linagliptin or a pharmaceutically acceptable slat thereof. Further aspects of the present invention relates to process for the preparation of Linagliptin key intermediate, having purity more than 98.0%.

First claim

1 - 24 . (canceled)

25 . A process for the preparation of Linagliptin of Formula I

or its pharmaceutically acceptable salt, which comprises steps of
a) condensation of 2-(chloromethyl)-4-methylquinazoline compound of Formula A

or its pharmaceutically acceptable salt with 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione of Formula B

or its pharmaceutically acceptable salt, in presence of suitable base in suitable solvent and water to obtain 8-bromo xanthine of compound of Formula II or its pharmaceutically acceptable salt.

b) purification of 8-bromo xanthine of Formula II obtained in step a) in suitable solvent to obtain substantially pure 8-bromo xanthine of Formula II
c) condensation of 8-bromo xanthine compound of Formula II or its pharmaceutically acceptable salt obtained in step b) with 3-(R)-Boc aminopiperidine of Formula C

or its pharmaceutically acceptable salt, in presence of suitable base in suitable solvent to obtain substantially pure Boc-Linagliptin of Formula III

or its pharmaceutically acceptable salt
d) deprotection of Boc-Linagliptin of step c) using triflouroacetic acid in presence of dichloromethane to obtain crude Linagliptin.
e) optionally, treating step (d) product with suitable acid base to obtain substantially pure Linagliptin.

26 . The process according to claim 25 , wherein the suitable solvent is selected from the group comprising one or more dimethyl acetamide, dimethyl formamide and dimethyl sulfoxide or mixture thereof.

27 . The process according to claim 26 , wherein the suitable solvent used in step (b) and (c) is combination of dimethyl acetamide, dimethyl formamide, dimethyl sulfoxide and water.

28 . The process according to claim 25 , wherein suitable base used in step a) and c) comprising one or more of inorganic bases or organic bases or mixture thereof.

29 . The process according to claim 25 , wherein the substantially pure 8-bromo xanthine has the purity more than 99% by HPLC.

30 . The process according to claim 25 , wherein the substantially pure Boc-Linagliptin has the purity more than 98% by HPLC.

31 . A substantially pure 8-bromo xanthine of Formula II

or its pharmaceutically acceptable salt

32 . A process for the preparation of Linagliptin of Formula I

or its pharmaceutically acceptable salt, which comprising
a) condensing the substantially 8-bromo xanthine compound of Formula II

or its pharmaceutically acceptable salt with 3-(R)-Boc aminopiperidine of Formula C

or its pharmaceutically acceptable salt using organic base in presence of suitable solvent to obtain substantially pure Boc-Linagliptin of Formula III

b) deprotection of Boc-linagliptin using trifluoroacetic acid in presence of dichloromethane to obtain crude linagliptin and (b) treatment with suitable acid base to obtain substantially pure Linagliptin.

33 . The according to claim 32 , wherein the organic base is selected from the group of triethyl amine (Et3N), trimethyl amine (Me3N), pyridine, tributylamine and diisopropyl ethyl amine (DIPEA).

34 . The process according to claim 32 , wherein suitable solvent is selected from dimethyl formamide, dimethylacetamide, dimethyl sulfoxide and water or mixtures thereof.

35 . The process according to claim 32 , wherein the substantially pure Boc-Linagliptin has the purity more than 95% by HPLC.

36 . The process according to claim 32 , wherein the 3-(R)-Bocaminopiperidine or its salt is 1 to 1.5 molar equivalents for the equivalent of 8-bromo xanthine of Formula II or its salt.

37 . The process according to claim 32 , wherein the base is 1 to 4 molar equivalents per the equivalent of the compound of Formula II or its salt.

38 . The process according to claim 32 , wherein the condensation reaction is performed at elevated temperature of about 45° C. to 11° C.

39 . The process according to claim 25 , wherein the Linagliptin is substantially free of “impurity-A”.

Assignees

• Wockhardt Ltd

Inventors

• Reddy Naveen
• Naidu Damodara K
• Raut Vivek Thakaram
• Rao Bhatraju Srinivasa
• Deo Keshav

Classifications

• C07D473/04 Primary

  two oxygen atoms · CPC title

• C07D487/04

  Ortho-condensed systems · CPC title