Methods and systems for integrated radiopharmaceutical generation, preparation, transportation and administration

Patent metadata

Field	Value
Publication number	US-2016303397-A1
Application number	US-201615142000-A
Country	US
Kind code	A1
Filing date	Apr 29, 2016
Priority date	Jan 1, 2007
Publication date	Oct 20, 2016
Grant date	—

Abstract

An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.

First claim

The invention claimed is:

1 . A hazardous fluid handling system comprising:
a pump; a pump control device electronically linked to the pump; a user interface wirelessly coupled to the pump control device; a radiation shielded internal chamber disposed within a housing and configured to hold a container holding a radioactive fluid and having a known internal geometry; at least two radioactivity detectors positioned within the shielded internal chamber in operational proximity to the radioactive fluid in the container; and a dosimeter control device electronically coupled to each of the at least two radioactivity detectors, wherein the dosimeter control device is operational for determining information on a fill volume of the radioactive fluid in the container based on individual measurements received from the at least two radioactivity detectors, and wherein the dosimeter control device is configured to use the individual measurements received from the at least two radioactivity detectors for determining error information comprising at least one of a presence of bubbles in the container and a presence of spills or leaks of the radioactive fluid from the container.

2 . The hazardous fluid handling system of claim 1 , wherein the dosimeter control device is electronically linked to the pump control device.

3 . The hazardous fluid handling system of claim 1 , further comprising a data recording device electronically linked to the dosimeter control device.

4 . The hazardous fluid handling system of claim 1 , further comprising a communications interface electronically linked to the pump control device.

5 . The hazardous fluid handling system of claim 4 , wherein the communications interface is configured to wirelessly link to an information network.

6 . The hazardous fluid handling system of claim 1 , further comprising a fluid path in fluid communication with the pump.

7 . The hazardous fluid handling system of claim 1 , wherein the user interface is a handheld user interface wirelessly coupled to the pump control device.

8 . The hazardous fluid handling system of claim 1 , wherein the hazardous fluid handling system is integrated into a patient support platform.

9 . The hazardous fluid handling system of claim 8 , wherein the patient support platform comprises:
a patient stimulus apparatus; an imager proximate the patient support platform; a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient; a patient monitor to be associated with the patient; and an integrated system controller operably associated with the patient stimulus apparatus, the imager, the radiopharmaceutical fluid delivery system, and the patient monitor.

10 . The hazardous fluid handling system of claim 1 , wherein the dosimeter control device receives a signal from each of the at least two radioactivity detectors and is capable of determining an activity of the radioactive fluid in the container.

11 . The hazardous fluid handling system of claim 1 , wherein the two or more radioactivity detectors are positioned at a different vertical location relative to the internal chamber.

12 . The hazardous fluid handling system of claim 1 , further comprising at least one position sensor, wherein the dosimeter control device is operational for determining the fill volume and one or more additional property of the system based on individual measurements received from the at least two radioactivity detectors and the at least one position sensor.

13 . A hazardous fluid handling system comprising:
a pump; a pump control device electronically linked to the pump; a user interface wirelessly coupled to the pump control device; a radiation shielded internal chamber disposed within a housing and configured to hold a container holding a radioactive fluid and having a known internal geometry; at least one radioactivity detector positioned within the shielded internal chamber in operational proximity to detect radiation emitted by the radioactive fluid in the container; a position sensor; and a dosimeter control device electronically coupled with the at least one radioactivity detector and the position sensor, wherein the dosimeter control device is operational for determining an activity of the radioactive fluid in the container based on measurements received from the at least one radioactivity detector and the position sensor, and wherein the dosimeter control device is configured to use individual measurements received from the at least one radioactivity detector and the position sensor for determining error information comprising at least one of a presence of bubbles in the container and a presence of spills or leaks of the radioactive fluid from the container.

14 . The hazardous fluid handling system of claim 13 , further comprising a data recording device electronically linked to the dosimeter control device.

15 . The hazardous fluid handling system of claim 13 , wherein the dosimeter control device receives a signal from at least two radioactivity detectors and the position sensor and is capable of determining the activity of the radioactive fluid in the container and at least one additional property of the system.

16 . The hazardous fluid handling system of claim 13 , wherein the dosimeter control device is electronically linked to the pump control device.

17 . The hazardous fluid handling system of claim 16 , wherein the communications interface is wirelessly linked to an information network.

18 . The hazardous fluid handling system of claim 13 , wherein the user interface is a handheld user interface wirelessly coupled to the pump control device.

19 . The hazardous fluid handling system of claim 13 , wherein the hazardous fluid handling system is integrated into a patient support platform.

20 . The hazardous fluid handling system of claim 19 , wherein the patient support platform comprises:
a patient stimulus apparatus; an imager proximate the patient support platform; a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient; a patient monitor to be associated with the patient; and an integrated system controller operably associated with the patient stimulus apparatus, the imager, the radiopharmaceutical fluid delivery system, and the patient monitor.

Assignees

• Bayer Healthcare Llc

Inventors

• Hirschman Alan D
• Uber Iii Arthur E
• Reilly David M
• Kalafut John F
• Trombley Iii Frederick W
• Remis Steven J
• Griffith Scott
• Descalzi Douglas
• Dewit Richard
• Griffiths David M
• Mabie Marc A
• Trocki Mark

Classifications

• A61M5/16881

  Regulating valves (on-off valves, e.g. clamps A61M39/28) · CPC title

• G21G4/08

  specially adapted for medical application (radiation therapy using radioactive sources A61N5/10) · CPC title

• A61M5/1785

  comprising radioactive shield means (syringe shields or holders for storage of radioactive sources G21F5/018) · CPC title

• A61B6/4057

  by using radiation sources located in the interior of the body (A61B6/037 takes precedence) · CPC title

• A61M5/1723

  using feedback of body parameters, e.g. blood-sugar, pressure (measurement of body parameters A61B5/00) · CPC title