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Methods and devices for desmopressin drug delivery
US2016303185A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016303185-A1 |
| Application number | US-201615193966-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jun 27, 2016 |
| Priority date | Aug 6, 2007 |
| Publication date | Oct 20, 2016 |
| Grant date | — |
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Abstract
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Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices are designed to permit a state of normal urinary production to return quickly after the desmopressin flux is terminated.
First claim
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We claim: 1 . A device for modulating urine production in a patient, the device comprising: an interface member for application to the skin of a patient comprising a microstructure comprising or coated with releasable desmopressin, the microstructure being configured to enter the patient's intradermal compartment when said device is applied to the skin of the patient, thereby to release desmopressin into the circulatory system of the patient at a flux rate: i) sufficient to establish and maintain a desmopressin concentration in the blood of the patient within the range of about 0.2 to 5 pg/ml and ii) insufficient to induce a desmopressin concentration in the blood of the patient greater than about 5 pg/ml. 2 . The device of claim 32 , wherein the microstructure is a microneedle. 3 . The device of claim 33 , comprising a plurality of microneedles having tips comprising or coated with releasable desmopressin. 4 . The device of claim 32 , wherein the microstructure is a micropellet.
Assignees
Inventors
Classifications
- A61K38/095Primary
Oxytocins; Vasopressins; Related peptides · CPC title
Antidiuretics, e.g. drugs for diabetes insipidus (ADH A61P5/10) · CPC title
Drugs for disorders of the urinary system · CPC title
by using microneedles · CPC title
- A61K38/12Primary
Cyclic peptides {, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C (A61K38/043 - A61K38/046 take precedence)} · CPC title
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- What does patent US2016303185A1 cover?
- Disclosed are devices for urine voiding postponement, and methods for treating conditions such as central diabetes insipidus, enuresis, nocturia, urinary frequency or incontinence. The devices deliver a desmopressin flux through the skin of a patient in a low dose amount just necessary to achieve a desired anti-diuretic effect without undesirable side effects such as hyponatremia. The devices a…
- Who is the assignee on this patent?
- Allergan Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K38/095. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu Oct 20 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).