System and Method for Medical Fluid Identification and Verification

Patent metadata

Field	Value
Publication number	US-2016296692-A1
Application number	US-201415038493-A
Country	US
Kind code	A1
Filing date	Nov 25, 2014
Priority date	Nov 26, 2013
Publication date	Oct 13, 2016
Grant date	—

Abstract

A system for injecting fluid to a patient is provided. The system provides manual or automatic verification and identification of the fluid to be injected, prior to, during or after injection. The system includes: a fluid having at least one active compound and at least one tracer compound; an injector configured to deliver the fluid to the patient through a fluid path set; at least one sensor coupled to at least one of the syringe, the injector, or the patient, configured to measure at least one property of the tracer in the fluid, and a feedback path to adjust at least one injection parameter of the injector based on at least one measurement from the at least one sensor.

First claim

1 . A system for injection of a fluid into a patient, the system comprising:
a fluid having at least one active compound and at least one tracer compound; an injector configured to deliver the fluid to a patient through a fluid path set; at least one sensor coupled to at least one of a fluid container associated with the injector, the fluid path set, the injector, and the patient, wherein the at least one sensor is configured to measure at least one property of the at least one tracer compound in the fluid; and a feedback path configured to adjust at least one injection parameter of the injector based on at least one measurement from the at least one sensor, wherein the at least one tracer compound comprises at least one nanoparticle, at least one dissolved molecule, or at least one microbubble.

2 . (canceled)

3 . (canceled)

4 . The system of claim 1 , wherein the at least one tracer compound comprises at least one nanoparticle.

5 . The system of claim 4 , wherein the at least one nanoparticle is capable of absorbing electromagnetic radiation having at least one first wavelength and emitting electromagnetic radiation having at least one second wavelength.

6 . The system of claim 5 , wherein the at least one sensor is configured to detect the electromagnetic radiation having the at least one second wavelength.

7 . The system of claim 5 , wherein the at least one sensor comprises an electromagnetic radiation source for emitting the electromagnetic radiation having the at least one first wavelength and an electromagnetic radiation detector for detecting the electromagnetic radiation having the at least one second wavelength.

8 . The system of claim 5 , wherein the at least one nanoparticle comprises at least one up-converting fluorescent nanocrystal or at least one down-converting nanoparticle.

9 . The system of claim 8 , wherein the at least one up-converting fluorescent nanocrystal comprises a compound that absorbs two or more low-energy photons having the at least one first wavelength in an infrared region of an electromagnetic spectrum and emits at least one higher energy photon having the at least one second wavelength in a visible region of the electromagnetic spectrum.

10 . The system of claim 9 , wherein the at least one second wavelength is in the green or blue region of the visible region and wherein the higher energy photon can penetrate through at least a portion of a tissue of a patient

11 . (canceled)

12 . The system of claim 4 , wherein the nanoparticle is substantially inert to biological systems and has at least one of a size and shape below a renal threshold for excretion.

13 . The system of claim 1 , wherein at least one sensor is coupled to a tissue section of the patient and the at least one property is selected from a concentration of the tracer at a site within the patient near the tissue section, a location of the tracer within a vascular system of the patient near the tissue section, an extravasation of the tracer outside the vascular system of the patient near the tissue section, and combinations of any thereof.

14 . (canceled)

15 . The system of claim 1 , wherein the at least one sensor is at least one of a photocell patch and a camera.

16 . The system of claim 1 , wherein the feedback path is a servo control feedback loop comprising a controller configured to receive the at least one measurement from the at least one sensor and adjust the at least one injection parameter of the injector in a real time manner based on the at least one measurement.

17 . The system of claim 16 , wherein the at least one injection parameter of the injector is selected from decreasing an injection rate, increasing an injection rate, stopping an injection, changing an injection stop time, and changing a concentration of the at least one active compound in the fluid.

18 . The system of claim 1 , wherein at least one of the at least one active compound and the at least one tracer is contained in at least one syringe or at least one multi-dose container and the injector is configured to receive the at least one syringe or at least one multi-dose container and deliver the fluid in the at least one syringe or at least one multi-dose container to the patient through the fluid path set.

19 . The system of claim 1 , wherein the injector comprises at least two syringes, wherein a first syringe contains the fluid having the at least one active compound and the at least one tracer compound and a second syringe contains saline or other flushing fluid.

20 . The system of claim 1 , wherein the at least one active compound comprises a contrast agent and the tracer comprises at least one compound or nanoparticle capable of absorbing electromagnetic radiation having at least one first wavelength and emitting electromagnetic radiation having at least one second wavelength.

21 . A method for measuring a property of an injected fluid in a vascular system, the method comprising:
injecting a fluid comprising at least one active compound and at least one nanoparticle tracer compound into a vascular system of a patient; associating at least one sensor with a tissue section of the patient, wherein the tissue section is adjacent to a portion of the vascular system, and wherein the at least one sensor comprises an electromagnetic radiation source for emitting electromagnetic radiation having at least one first wavelength and an electromagnetic radiation detector for detecting electromagnetic radiation having at least one second wavelength; irradiating the tissue section with the electromagnetic radiation having the at least one first wavelength from the electromagnetic radiation source; measuring at least one of the presence of electromagnetic radiation having the at least one second wavelength, the absence of electromagnetic radiation having the at least one second wavelength, and the location of the electromagnetic radiation having the at least one second wavelength using the electromagnetic radiation detector; and changing at least one injection parameter of the injector in a real time manner based on a result of the measuring step.

22 . The method of claim 21 , wherein the at least one nanoparticle tracer compound comprises at least one up-converting fluorescent nanocrystal and the at least one active compound comprises a contrast agent.

23 . The method of claim 21 , further comprising determining from the measuring of the electromagnetic radiation having the at least one second wavelength one or more of a flow rate of the at least one active compound in the vascular system, the direction of flow of the at least one active compound in the vascular system, a presence of air in the vascular system, a presence of extravasation of the at least one active compound, a volume rate of the at least one active compound in the vascular system, a bolus concentration of the injected fluid, a bolus sharpness of the injected fluid, a value for an estimated glomerular filtration rate, and combinations of any thereof.

24 . A system for injection of a fluid into a patient comprising:
a fluid comprising at least one up-converting fluorescent nanocrystal; an injector configured to deliver the fluid to the patient through a fluid path set; at least one sensor coupled to a tissue section of the patient, wherein the at least one sensor is configured to measure at least one property of the fluorescent nanocrystal in the fluid selected from the group con

Assignees

• Bayer Healthcare Llc
• Bayer Medical Care Inc

Inventors

• Agris Iii Jacob
• Uber Iii Arthur E
• Schriver Ralph H
• Zapatka Evelina
• Spohn Michael A

Classifications

• A61M2205/6063

  Optical identification systems · CPC title

• A61M5/1723

  using feedback of body parameters, e.g. blood-sugar, pressure (measurement of body parameters A61B5/00) · CPC title

• A61M2005/1403

  Flushing or purging · CPC title

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M5/007 Primary

  for contrast media · CPC title