NMR Flow Cell

Patent metadata

Field	Value
Publication number	US-2016290941-A1
Application number	US-201615071331-A
Country	US
Kind code	A1
Filing date	Mar 16, 2016
Priority date	Apr 2, 2015
Publication date	Oct 6, 2016
Grant date	—

Abstract

Monitoring cell ( 100 ) for performing an NMR measurement of a reaction fluid. The monitoring cell ( 100 ) has a hollow NMR sample probe ( 110 ) for receiving the reaction fluid. Inlet and outlet transport capillaries ( 112, 123 ) transport the reaction fluid to and from the sample probe ( 110 ). A feed line ( 306 ) and return line transport a temperature control fluid to and from the monitoring cell ( 100 ). An adapter head ( 108 ) couples the transport capillaries ( 112, 123 ) to the sample probe ( 110 ) and removably connects the sample probe ( 110 ) to an adapter section ( 106 ). The transport capillaries ( 112, 123 ) are positioned within the feed line ( 306 ) in parallel to one another. The feed and the return lines ( 306, 358 ) are attached to the adapter section ( 106 ) such that a reversal of the temperature control fluid stream occurs in the adapter section ( 106 ).

First claim

I claim:

1 . A monitoring cell for performing a measurement in an NMR spectrometer of a reaction fluid produced in a reaction vessel, the monitoring cell comprising:
a hollow NMR sample probe for receiving the reaction fluid to be measured in the NMR spectrometer; an inlet transport capillary for receiving the reaction fluid from the reaction vessel and for transport of the reaction fluid from the reaction vessel to said sample probe; an outlet transport capillary for return transport of the reaction fluid from said sample probe to the reaction vessel; a device for conducting a temperature control fluid around said inlet and outlet transport capillaries, said device comprising a feed line for feeding the temperature control fluid to the monitoring cell and a return line for return of the temperature control fluid from the monitoring cell, said feed line being coaxially positioned within said return line; an adapter section, through which said inlet and outlet transport capillaries are fed; and an adapter head disposed on a sample-side end of said adapter section, said adapter head being configured for coupling said inlet and outlet transport capillaries to said sample probe, wherein said inlet transport capillary extends into said sample probe and said adapter head connects said sample probe to said adapter section in a detachable manner, said net and outlet transport capillaries thereby being positioned within said feed line in parallel to one another and not coaxially and each of said inlet and outlet transport capillaries is attached to said adapter head in a fluid-tight manner, wherein said feed and said return lines are configured for the temperature control fluid and attached to said adapter section in such a way that a reversal of a temperature control fluid stream occurs in said adapter section.

2 . The monitoring cell of claim 1 , wherein said feed line and said return line communicate with one another via a hollow volume of said adapter section in such a way that the temperature control fluid stream is reversed in said adapter section.

3 . The monitoring cell of claim 1 , wherein said inlet transport capillary immerses more deeply in said sample probe than said outlet transport capillary.

4 . The monitoring cell of claim 3 , wherein said outlet transport capillary terminates at said adapter head and does not immerse in said sample probe.

5 . The monitoring cell of claim 1 , wherein said adapter section and said adapter head comprise a heat insulation towards an outside.

6 . The monitoring cell of claim 1 , wherein said adapter head is made from polytetrafluoroethylene.

7 . The monitoring cell of claim 6 , wherein said polytetrafluoroethylene is fiberglass reinforced.

8 . The monitoring cell of claim 1 , further comprising a quick release or bayonet connector that can be detached manually or without tools and which is disposed between said sample probe and said adapter head.

9 . The monitoring cell of claim 1 , wherein said inlet and outlet transport capillaries have identical outer dimensions.

10 . The monitoring cell of claim 1 , wherein said inlet and outlet transport capillaries are made from chemically inert plastic or from PTFE.

11 . The monitoring cell of claim 1 , wherein said outlet transport capillary has a larger inner diameter than that of said inlet transport capillary.

12 . The monitoring cell of claim 11 , wherein said outlet transport cavity has an inner diameter which is twice as large as that of said inlet transport capillary.

13 . The monitoring cell of claim 1 , wherein said inlet and outlet transport capillaries have inner diameters between 0.1 mm and 1.2 mm or between 0.2 and 0.5 mm.

14 . The monitoring cell of claim 1 , wherein, over a distance of 3 m to 6 m, said feed line and said return line have an inner diameter between 2 mm and 10 mm, of about 3.5 mm for said feed line or of about 7 mm for said return line.

15 . The monitoring cell of claim 1 , further comprising a first Y-shaped coupling piece with which said inlet and outlet transport capillaries can be inserted into said device for conducting the temperature control fluid.

16 . The monitoring cell of claim 15 , further comprising a second Y-shaped coupling piece with which said feed line and said return line can be inserted in said device for conducting the temperature control fluid.

17 . The monitoring cell of claim 16 , wherein an inlet and an outlet said first and said second of Y-shaped coupling pieces enclose an angle of about 45°.

18 . The monitoring cell of claim 1 , wherein the temperature control fluid is a liquid.

Assignees

• Bruker Biospin Gmbh

Inventors

• Hofmann Martin

Classifications

• G01R33/31

  Temperature control thereof · CPC title

• G01N24/08 Primary

  by using nuclear magnetic resonance (G01N24/12 takes precedence) · CPC title

• G01N24/088

  Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics · CPC title

• G01R33/46

  NMR spectroscopy · CPC title

• G01R33/307 Primary

  specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer · CPC title