Prevention of infarct expansion

Patent metadata

Field	Value
Publication number	US-2016287632-A1
Application number	US-201514962889-A
Country	US
Kind code	A1
Filing date	Dec 8, 2015
Priority date	Sep 21, 2007
Publication date	Oct 6, 2016
Grant date	—

Abstract

Provided are methods and kits for safe and effective therapy that can be administered early after a heart attack in order to prevent progressive heart dilatation and resultant loss of function. The therapy includes the administration of particulate compositions to a region comprising an infarct or a portion thereof.

First claim

1 .- 16 . (canceled)

17 . A kit for use in the stabilization of cardiac infarct tissue comprising:
a composition comprising a biologically compatible, acellular material comprising particles having characteristic dimensions of 25 μm to about 50 μm; and, an injection tool capable of delivering said composition directly into a cardiac infarct itself, and optionally into a region of tissue containing the infarct, into tissue adjacent to or partially or completely surrounding the infarct, or both within a living patient.

18 . The kit according to claim 17 wherein said material comprises microparticles of one or more forms of calcium phosphate.

19 . The kit according to claim 17 wherein said composition comprises a suspension of said microparticles in an aqueous carrier.

20 . The kit according to claim 17 wherein said injection tool comprises a catheter.

21 . The kit according to claim 17 wherein said composition is provided in one or more premeasured aliquots.

22 .- 25 . (canceled)

Assignees

• Univ Pennsylvania

Inventors

• Gorman Robert C
• Gorman Iii Joseph H
• Ryan Liam P

Classifications

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L27/12

  Phosphorus-containing materials, e.g. apatite · CPC title

• A61L27/54

  Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} · CPC title

• A61L27/10

  Ceramics or glasses · CPC title