Scaffold system for tissue repair

Patent metadata

Field	Value
Publication number	US-2016287415-A1
Application number	US-201615043968-A
Country	US
Kind code	A1
Filing date	Feb 15, 2016
Priority date	Feb 13, 2012
Publication date	Oct 6, 2016
Grant date	—

Abstract

A device for treating a damaged tissue includes an expandable scaffold positionable in a portion of a luminal tissue structure of a mammal; and maintained via stent technology, wherein the scaffold is comprised of electrospun fibers composed of a biodegradable compound. The scaffold serves as a temporary template that allows the tissue to be rebuilt.

First claim

1 - 30 . (canceled)

31 . A vascular tissue repair device, comprising:
a generally tubular intraluminal scaffold having a luminal surface and an abluminal surface and being composed of nonwoven fibers made of a biodegradable and/or bioresorbable material, the luminal surface being comprised of substantially curvilinear nonwoven fibers and the abluminal surface comprising substantially linear fibers and the abluminal surface being adapted to face and be in apposition to a luminal wall of the vascular tissue; wherein the generally tubular intraluminal scaffold has an average porosity capable of cellular permeability.

32 . The vascular tissue repair device according to claim 31 , wherein the nonwoven fibers are made of poly(α-hydroxy esters).

33 . The vascular tissue repair device according to claim 31 , wherein the nonwoven fibers are made of polycaprolactone.

34 . The vascular tissue repair device according to claim 31 , wherein the generally tubular intraluminal scaffold further comprises elastin, collagen, DNA, RNA, glucosaminoglycans, polyhydroxyalkanoates or mixtures thereof.

35 . The vascular tissue repair device according to claim 31 , further comprising a stent.

36 . The vascular tissue repair device according to claim 35 , wherein the stent and the generally tubular intraluminal scaffold are diametrically expandable into apposition with the luminal wall of the vascular tissue.

37 . The vascular tissue repair device according to claim 31 , wherein the nonwoven fibers are electrospun fibers.

38 . The vascular tissue repair device according to claim 31 , wherein the nonwoven fibers are electrospun fibers and the stent is incorporated into the electrospun fibers.

39 . The vascular tissue repair device according to claim 31 , wherein the nonwoven fibers are treated with chemical agents, therapeutic agents or with gas plasma.

Assignees

• Univ Texas

Inventors

• Kaufmann J Jordan Massey
• Agrawal C Mauli
• Bailey Steven R

Classifications

• A61F2210/0004

  bioabsorbable · CPC title

• A61L27/34

  Macromolecular materials · CPC title

• A61L31/10

  Macromolecular materials · CPC title

• A61L31/146

  Porous materials, e.g. foams or sponges · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title