Prosthetic valves and associated appartuses, systems and methods

Patent metadata

Field	Value
Publication number	US-2016287384-A1
Application number	US-201615162909-A
Country	US
Kind code	A1
Filing date	May 24, 2016
Priority date	May 3, 2013
Publication date	Oct 6, 2016
Grant date	—

Abstract

A valve prosthesis includes an expandable frame comprising an outflow portion and an inflow portion connected to the outflow portion. The frame defines a central lumen extending between the outflow portion and the inflow portion. The frame is generally cylindrical in a fully expanded configuration. When the frame is in the fully expanded configuration, an outer surface of the inflow portion is concave. The inflow portion has an upper inflow portion and a lower inflow portion. When the frame is in the fully expanded configuration, the upper inflow portion flares outwardly from the central lumen of the frame to greater extent than the lower inflow portion.

First claim

1 . A valve prosthesis comprising:
an expandable frame comprising an outflow portion and an inflow portion connected to the outflow portion, the frame having a longitudinal axis and defining a central lumen extending between the outflow portion and the inflow portion, wherein the frame is generally cylindrical in a fully expanded configuration, wherein, when the frame is in a fully expanded configuration, (i) an outer surface of the inflow portion is concave, (ii) the inflow portion has an upper inflow portion defining an upper edge, a lower inflow portion defining a lower edge, and a waist between the upper edge and the lower edge, (iii) the upper inflow portion flares outwardly from the longitudinal axis and the central lumen of the frame to greater extent than the lower inflow portion, (iv) a transverse distance from the upper inflow portion to the longitudinal axis of the frame continuously increases from the waist to the upper edge, and (v) a transverse distance from the lower inflow portion to the longitudinal axis of the frame continuously increases from the waist to the lower edge.

2 . A valve prosthesis according to claim 1 , wherein the upper inflow portion flares outwardly away from the longitudinal axis of the frame at an angle that is greater than an angle at which the lower inflow portion flares.

3 . A valve prosthesis according to claim 2 , wherein the upper inflow portion flares outwardly from the longitudinal axis of the frame at an angle from about 40° to about 60°, and wherein the lower inflow portion flares outwardly from the longitudinal axis of the frame at an angle from about 10° to about 30°.

4 . A valve prosthesis according to claim 2 , wherein the upper inflow portion flares outwardly from the longitudinal axis of the frame at an angle from about 45° to about 55°, and wherein the lower inflow portion flares outwardly from the longitudinal axis of the frame at an angle from about 15° to about 25°.

5 . A valve prosthesis according to claim 1 , wherein the waist of the inflow portion defines a circumference, wherein the upper edge of the upper inflow portion defines a circumference and the lower edge of the lower inflow portion defines a circumference, wherein the circumference of the upper edge is from about 115% to about 135% of the circumference of the waist and wherein the circumference of the lower edge of the lower inflow portion is from about 105% to about 120% of the circumference of the waist, provided that the circumference of the upper edge of the upper inflow portion is greater than the diameter of the lower inflow edge.

6 . A valve prosthesis according to claim 5 , wherein the circumference of the upper edge of the upper inflow portion is from about 120% to about 130% of the circumference of the waist and wherein the circumference of the lower edge of the lower inflow portion is from about 108% to about 117% of the diameter of the waist, provided that the circumference of the upper edge of the upper inflow portion is greater than the diameter of the lower edge of the lower inflow portion.

7 . A valve prosthesis according to claim 1 , wherein the upper edge of the upper inflow portion defines a circumference and the lower edge of the lower inflow portion defines a circumference, wherein the circumference of the upper edge of the upper inflow portion is from about 105% to about 115% of the circumference of the lower edge of the lower inflow portion.

8 . A valve prosthesis according to claim 1 , wherein the inflow portion comprises a plurality of closed cells, wherein each cell is connected to an adjacent cell along the waist.

9 . A valve prosthesis according to claim 1 , wherein the outflow portion of the frame has an upper portion flared inwardly towards the central lumen.

10 . A valve prosthesis according to claim 9 , wherein the outflow portion of the frame has a lower portion and a middle portion that together are generally cylindrical, wherein the upper outflow portion defines an edge defining a circumference, and wherein the circumference of the edge of the upper outflow portion is from about 75% to about 97% of a circumference of the middle and lower outflow portions.

11 . A valve prosthesis according to claim 10 , wherein the circumference of the edge of the upper outflow portion is from about 80% to about 95% of the circumference of the middle and lower outflow portions.

12 . A valve prosthesis according to claim 1 , wherein the outflow portion comprises (i) an undulating upper outflow portion having peaks and valleys, (ii) an undulating middle outflow portion having peaks and valleys, and (iii) an undulating lower outflow portion having peaks and valleys, wherein the valleys of the undulating upper outflow portion are connected to the peaks of the undulating middle inflow portion, and wherein the valleys of the undulating middle outflow portion are connected to the peaks of the undulating lower outflow portion.

13 . A valve prosthesis according to claim 12 , wherein a height of the upper outflow portion is greater than a height of the lower outflow portion, and wherein the height of the upper outflow portion is less than a height of the middle outflow portion.

14 . A valve prosthesis according to claim 12 , wherein the inflow portion comprises a plurality of closed cells connected along the waist, and wherein the valleys of the undulating lower outflow portion are connected to the inflow portion along the waist between the closed cells.

15 . A valve prosthesis according to claim 14 , wherein the valleys of the undulating lower outflow portion are connected to the inflow portion along the waist via posts.

16 . A valve prosthesis according to claim 1 , wherein the frame comprises a plurality of enclosed wire form cells interconnected with one another.

17 . A valve prosthesis according to claim 1 , wherein the frame is a self-expanding frame.

18 . A valve prosthesis according to claim 1 , further comprising a valve body attached to the frame.

19 . A valve prosthesis comprising:
an expandable frame comprising an outflow portion and an inflow portion connected to the outflow portion, the frame having a longitudinal axis and defining a central lumen extending between the outflow portion and the inflow portion, wherein the frame is generally cylindrical in a fully expanded configuration, wherein, when the frame is in a fully expanded configuration, (i) the inflow portion has an upper portion defining an upper edge and has a lower portion defining a lower edge; (ii) the inflow portion comprises a plurality of closed cells, each of the closed cells having an upper free end and a lower free end, wherein the upper free ends of the plurality of closed cells defines a circumference around the upper edge of the inflow portion, and wherein the lower free ends of the plurality of closed cells defines a circumference around the lower edge of the inflow portion; and (iii) the upper inflow portion flares outwardly from the central lumen of the frame to greater extent than the lower inflow portion.

Assignees

• Medtronic Inc

Inventors

• Gloss Michael
• Groen Timothy
• Majkrzak Carolyn
• Rust Matthew
• Ryan Timothy
• Weston Matthew

Classifications

• A61F2250/0039

  differing in diameter · CPC title

• A61F2230/0069

  cylindrical · CPC title

• A61F2/2469

  with resilient valve members, e.g. conical spiral · CPC title

• A61F2/07

  Stent-grafts · CPC title

• A61F2/2409

  Support rings therefor, e.g. for connecting valves to tissue (annuloplasty rings A61F2/2442) · CPC title