Systems and methods for providing personalized estimates of bioheat transfer

Patent metadata

Field	Value
Publication number	US-2016287338-A1
Application number	US-201615088626-A
Country	US
Kind code	A1
Filing date	Apr 1, 2016
Priority date	Apr 2, 2015
Publication date	Oct 6, 2016
Grant date	—

Abstract

Systems and methods are disclosed for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and output the determined estimate of heat distribution to a storage medium or user display.

First claim

What is claimed is:

1 . A computer-implemented method of providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body, the method comprising:
receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and outputting the determined estimate of heat distribution to a storage medium or user display.

2 . The computer-implemented method of claim 1 , wherein the estimate of heat content of the portion of tissue comprises the heat content of the portion of tissue or the surrounding tissue at a first point of time; and
wherein the estimate of heat distribution comprises heat distribution at a second point of time different from the first point of time.

3 . The computer-implemented method of claim 1 , wherein the estimate of heat content is estimated as a homogenous value.

4 . The computer-implemented method of claim 3 , further comprising:
determining an introduction of a temperature source in a location of the tissue model or vascular model, wherein the estimate of heat content is homogenous except for the location of the temperature source.

5 . The computer-implemented method of claim 4 , wherein the temperature source is associated with ablation, a heating apparatus, or a cooling apparatus.

6 . The computer-implemented method of claim 1 , further comprising:
determining, using the vascular model, blood flow demand of the tissue model.

7 . The computer-implemented method of claim 6 , further comprising:
determining the estimate of heat distribution based on the determined blood flow demand and a heat transfer equation.

8 . The computer-implemented method of claim 1 , wherein the vascular model includes large vessels and microvasculature of the patient's anatomy.

9 . A system for providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body, the system comprising:
a data storage device storing instructions of providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body; and a processor configured to execute the instructions to perform a method including:
receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient;
receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy;
receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue;
determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and
outputting the determined estimate of heat distribution to a storage medium or user display.

10 . The system of claim 9 , wherein the estimate of heat content of the portion of tissue comprises the heat content of the portion of tissue or the surrounding tissue at a first point of time; and
wherein the estimate of heat distribution comprises heat distribution at a second point of time different from the first point of time.

11 . The system of claim 9 , wherein the estimate of heat content is estimated as a homogenous value.

12 . The system of claim 11 , wherein the system is further configured for:
determining an introduction of a temperature source in a location of the tissue model or vascular model, wherein the estimate of heat content is homogenous except for the location of the temperature source.

13 . The system of claim 12 , wherein the temperature source is associated with ablation, a heating apparatus, or a cooling apparatus.

14 . The system of claim 9 , wherein the system is further configured for:
determining, using the vascular model, blood flow demand of the tissue model.

15 . The system of claim 14 , wherein the system is further configured for:
determining the estimate of heat distribution based on the determined blood flow demand and a heat transfer equation.

16 . The system of claim 9 , wherein the vascular model includes large vessels and microvasculature of the patient's anatomy.

17 . A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of providing personalized estimates of bioheat transfer through a patient's body or a portion of a patient's body, the method comprising:
receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; receiving a patient-specific tissue model including at least a portion of tissue of the patient's anatomy; receiving an estimate of heat content of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue; determining an estimate of heat distribution of the portion of tissue of the patient-specific tissue model or tissue surrounding the portion of tissue based on the vascular model, the tissue model, or the received estimate of heat content; and outputting the determined estimate of heat distribution to a storage medium or user display.

18 . The non-transitory computer readable medium of claim 17 , wherein the estimate of heat content of the portion of tissue comprises the heat content of the portion of tissue or the surrounding tissue at a first point of time; and
wherein the estimate of heat distribution comprises heat distribution at a second point of time different from the first point of time.

19 . The non-transitory computer readable medium of claim 17 , wherein the estimate of heat content is estimated as a homogenous value.

20 . The non-transitory computer readable medium of claim 19 , the method further comprising:
determining an introduction of a temperature source in a location of the tissue model or vascular model, wherein the estimate of heat content is homogenous except for the location of the temperature source.

Assignees

• Heartflow Inc

Inventors

• Grady Leo
• Taylor Charles A
• Zarins Christopher K

Classifications

• A61F7/00

  Heating or cooling appliances for medical or therapeutic treatment of the human body (hyperthermia using electric or magnetic fields or ultrasound A61N) · CPC title

• A61B2034/104

  Modelling the effect of the tool, e.g. the effect of an implanted prosthesis or for predicting the effect of ablation or burring · CPC title

• A61B34/10 Primary

  Computer-aided planning, simulation or modelling of surgical operations · CPC title

• A61B2018/00577

  Ablation · CPC title

• A61B34/00

  Computer-aided surgery; Manipulators or robots specially adapted for use in surgery · CPC title