Non-invasive optical measurement of blood analyte

Patent metadata

Field	Value
Publication number	US-2016287154-A1
Application number	US-201615086520-A
Country	US
Kind code	A1
Filing date	Mar 31, 2016
Priority date	Apr 1, 2015
Publication date	Oct 6, 2016
Grant date	—

Abstract

Methods and devices for accurate noninvasive measurement of blood analyte concentrations are disclosed. In an example process, optical properties of a blood vessel proximate to the surface of an exposed body part, for example, the sclera or the backside of the eyelid, is measured. Analyte concentrations are determined based on the measured optical properties.

First claim

What is claimed is:

1 . A method comprising:
receiving, by a processing system from a light detector, information associated with first optical signals detected by the light detector, wherein the first optical signals are detected from a first area illuminated by a light source, wherein the first area includes a blood vessel, and wherein the blood vessel is proximate to a surface of an exposed body part; and determining, by the processing system, a concentration of a blood analyte based on the received information associated with the first optical signals.

2 . The method of claim 1 , wherein there is no skin layer between the blood vessel and the surface of the exposed body part at the first area.

3 . The method of claim 1 , wherein the first area is on an eye.

4 . The method of claim 1 , wherein the blood vessel is proximate to a surface of a sclera of an eye.

5 . The method of claim 1 , wherein the blood vessel is proximate to a surface of a backside of an eye lid.

6 . The method of claim 1 , wherein the blood analyte is one of glucose or oxidized hemoglobin.

7 . The method of claim 1 , wherein determining the concentration of the blood analyte comprises:
determining a light absorption profile from the information associated with the first optical signals detected by the light detector; and comparing the light absorption profile determined from the information associated the first optical signals to a plurality of pre-determined light absorption profiles having known blood analyte concentrations.

8 . The method of claim 1 , wherein determining the concentration of the blood analyte comprises:
determining, from the information associated with the first optical signals detected by the light detector, a first light absorption profile for an area having the blood vessel; determining, from the information associated with the first optical signals detected by the light detector, a second light absorption profile for an area not having the blood vessel; generating a differential light absorption profile based on differences between the first light absorption profile and the second light absorption profile; and determining the concentration of the blood analyte based on the differential light absorption profile.

9 . The method of claim 1 , further comprising:
receiving, by the processing system, from the light detector, information associated with second optical signals detected by the light detector, wherein the second optical signals are detected from a second area illuminated by the light source, wherein the second area is adjacent to the first area, and wherein the second area does not include a blood vessel; and calibrating, by the processing system, the concentration of the blood analyte based on the received information associated with the second optical signals.

10 . The method of claim 1 , further comprising:
receiving, by the processing system, from a temperature monitor, information associated with a temperature of the first area detected by the temperature monitor; and calibrating, by the processing system, the concentration of the blood analyte based on the information associated with the temperature.

11 . The method of claim 1 , wherein the information associated with the first optical signals comprises polarization rotation, Raman spectrum, optical coherence tomography, near infrared spectrum, or mid-infrared spectrum.

12 . The method of claim 1 , wherein the blood vessel at the first area is located less than 0.5 millimeter deep under the surface of the exposed body part.

13 . A non-invasive analyte detection device comprising:
a light source configured to illuminate a first area, wherein the first area includes a blood vessel, and wherein the blood vessel is proximate to a surface of an exposed body part; a light detector configured to detect first optical signals from the first area; and a processor configured to:
receive information associated with the first optical signals; and
determine a concentration of a blood analyte based on the received information associated with the first optical signals.

14 . The device of claim 13 , wherein the blood vessel is proximate to a surface of a sclera of an eye.

15 . The device of claim 13 , wherein the blood vessel is proximate to a surface of a backside of an eye lid.

16 . The device of claim 13 , wherein the blood analyte is glucose.

17 . The device of claim 13 , wherein the blood analyte is oxidized hemoglobin.

18 . The device of claim 13 , wherein:
the light source is further configured to illuminate a second area, wherein the second area is adjacent to the first area, and wherein the second area does not include a blood vessel; the light detector is further configured to detect second optical signals from the second area; and the processor is further configured to:
receive information associated with the second optical signals; and
calibrate the concentration of the blood analyte based on the received information associated with the second optical signals.

19 . The device of claim 13 , further comprising a temperature monitor configured to detect a temperature of the first area, wherein the processor is further configured to receive information associated with the detected temperature from the temperature monitor and to calibrate the concentration of the blood analyte based on the information associated with the temperature.

20 . The device of claim 13 , wherein the information associated with the first optical signals comprises polarization rotation, Raman spectrum, optical coherence tomography, near infrared spectrum, and mid-infrared spectrum.

Assignees

• Santec Corp

Inventors

• Chong Changho

Classifications

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/01

  Measuring temperature of body parts {; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue} (clinical contact thermometers G01K13/20) · CPC title

• A61B5/14555 Primary

  specially adapted for the eye fundus · CPC title

• A61B5/1495

  Calibrating or testing of in-vivo probes · CPC title