Composition for inhibition of insect host sensing

Patent metadata

Field	Value
Publication number	US-2016286807-A1
Application number	US-201615093593-A
Country	US
Kind code	A1
Filing date	Apr 7, 2016
Priority date	Oct 25, 2010
Publication date	Oct 6, 2016
Grant date	—

Abstract

The present invention provide chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit host targeting functions in insects such as mosquitos. Method of employing such agents, and articles incorporating the same, are also provided.

First claim

1 - 35 . (canceled)

36 . A method of disrupting odor sensing behavior in an organism having an ORco ion channel, comprising exposing the organism to a compound:

or a salt thereof.

37 . The method of claim 36 , wherein the organism is an insect.

38 . The method of claim 36 , wherein the organism is a crop pest.

39 . The method of claim 36 , wherein the organism is an airborne insect.

40 . The method of claim 36 , wherein the organism is a blood-sucking insect.

41 . The method of claim 36 , wherein the organism is of the suborder Ixodida.

42 . The method of claim 36 , wherein the organism is of the order Diptera.

43 . The method of claim 36 , wherein the organism is of the order Lepidoptera.

44 . A method of agonizing an ORco ion channel, comprising exposing the ORco ion channel to a compound:

or a salt thereof.

45 . The method of claim 44 , wherein the ORco ion channel is in vitro.

46 . The method of claim 45 , wherein the ORco ion channel is in a cultured cell.

47 . The method of claim 44 , wherein the ORco ion channel is in vivo.

48 . The method of claim 47 , wherein the ORco ion channel is in an insect.

49 . A composition comprising a compound:

or a salt thereof, and
one or more aerosolizers, film formers, ester-containing solvents, gelling agents, skin-conditioning agents, emollients, antioxidants, structuring agents, emulsifiers, silicone-containing compounds, essential oils, thickening agents, and/or vehicles.

50 . The composition of claim 49 , comprising one or more aerosolizers, gelling agents, emollients, emulsifiers, essential oils, and/or vehicles.

51 . An article comprising a compound:

or a salt thereof,
wherein the article is selected from misting system, bait, pellet, fabric, clothing, shelter, bedding, netting, and water soluble tablet.

52 . The article of claim 51 , comprising fabric, clothing, shelter, bedding, and/or netting.

Assignees

• Univ Vanderbilt

Inventors

• Zwiebel Laurence
• Pask Gregory M
• Rinker David
• Jones Patrick L

Classifications

• A01M1/2016

  for flying insects · CPC title

• A01M1/2005

  Poisoning insects using bait stations (A01M1/10 takes precedence) · CPC title

• A01N25/12

  Powders or granules (A01N25/26 takes precedence) · CPC title

• A01N43/653 Primary

  1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles · CPC title

• A01M2200/012

  Flying insects · CPC title