Buffer management and identification in bioprocessing system
US-11899028-B2 · Feb 13, 2024 · US
US2016281114A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016281114-A1 |
| Application number | US-201615080875-A |
| Country | US |
| Kind code | A1 |
| Filing date | Mar 25, 2016 |
| Priority date | Mar 25, 2015 |
| Publication date | Sep 29, 2016 |
| Grant date | — |
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According to an embodiment, there is provided herein a system and method wherein knowledge of the syngas fermentation is combined with standard instrumentation to provide a stable control of gas supply to automatically poise the fermentation to provide both high conversion of CO and H 2 , and high selectivity for production of ethanol. The control is based on an automatic feedback loop that corrects for operational imbalance and maintains a stable continuous fermentation required for commercial operation. In a further embodiment, feed of syngas to ethanol fermentation can be optimally controlled using the pH of the broth as the input variable for flow control of the gas. This concept will automatically maintain the correct supply of syngas to the fermentation, and provide stable operation at optimal rates.
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What is claimed is: 1 . A method of ethanol production via syngas fermantion, comprising the steps of: a. selecting an acetogenic microbial culture with solventogenic potential; b. selecting a pH set point; c. selecting a medium supportive of said acetogenic bacterial culture; d. selecting a feed gas; e. providing said medium to a bioreactor; f. providing a flow of said feed gas to said bioreactor at a first rate; g. operating said bioreactor to mix together said fee…
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