Foams for Oxygen Delivery to Wounds

Patent metadata

Field	Value
Publication number	US-2016279285-A1
Application number	US-201415033752-A
Country	US
Kind code	A1
Filing date	Nov 26, 2014
Priority date	Nov 26, 2013
Publication date	Sep 29, 2016
Grant date	—

Abstract

There is provided a composition comprising covalently linked segments of for example, polycaprolactone and polyethylene glycol that are linked by a cross-linker. Such a composition foams in the presence of a catalyst and a solution containing an oxygen forming chemical like hydrogen peroxide. The foamed composition retains oxygen for delivery to, for example, a wound, where it aids in healing.

First claim

What is claimed is:

1 . A composition comprising covalently linked segments of a biodegradable polymer such as but not limited to polycaprolactone, polylactide, polybutylene succinate, polyhydroxy alkanote, or a combination thereof and a hydrogel polymer such as but not limited to polyethylene glycol, polyhydroxylethylmethacrylate, polyacrylamide, polyacrylic acid, carboxylmethyl cellulose, guar gum, or a combination thereof.

2 . The composition of claim 1 , wherein the biodegradable polymer segment is desirably biodegradable with a weight loss of greater than 10 wt. % in 10 days, desirably without the release of toxic products from the biodegradation.

3 . The composition of claim 1 , further comprising a cross-linking agent that connects the biodegradable polymer and the hydrogel polymer.

4 . The composition of claim 3 , wherein the cross-linking agent comprises an isocyanate prepolymer or a cross-linker with isocyante content between 0.01 wt. % and 40 wt. % and and acid value between 0.01 mg and 100 mg of KOH/g of sample.

5 . The composition of claim 4 , wherein the cross-linking agent further comprises ionic segments.

6 . The composition of claim 5 , wherein the ionic segments are selected from the group consisting of carboxylic acids, sulfonic acids, phosphonic acids, and phosphinic acids.

7 . The composition of claim 1 , wherein the composition forms an oxygen containing foam upon exposure to a solution containing an oxygen forming chemical and a catalyst.

8 . The composition of claim 7 , wherein the hydrogel polymer has equal or greater than 20 percent nominal hydration in water containing an oxygen forming chemical.

9 . The composition of claim 8 , wherein the oxygen forming chemical is a peroxygen intermediate such as but not limited to hydrogen peroxide.

10 . The composition of claim 7 , wherein the catalyst is selected from the group consisting of alkali and alkaline earth metals and transition metal oxides.

11 . The composition of claim 10 , wherein the alkali and alkaline earth metals and transition metal oxides are selected from the group consisting of sodium carbonate, magnesium carbonate, manganese and silver.

12 . A biodegradable oxygen-containing foam comprising covalently linked segments of polycaprolactone and polyethylene glycol.

Assignees

• Avent Inc

Inventors

• Cuevas Brian J
• Lam Sophie Truc
• Bonn-Savage Nathan G
• Lalgudi Ramanathan S
• Roshon Melissa S
• Cain Robert Jonathan

Classifications

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L15/64

  specially adapted to be resorbable inside the body · CPC title

• A61L2300/11

  Peroxy compounds, peroxides, e.g. hydrogen peroxide · CPC title

• A61L26/0066 Primary

  Medicaments; Biocides · CPC title