Cobalamin acquisition protein and use thereof

Patent metadata

Field	Value
Publication number	US-2016279192-A1
Application number	US-201514958321-A
Country	US
Kind code	A1
Filing date	Dec 3, 2015
Priority date	Apr 30, 2012
Publication date	Sep 29, 2016
Grant date	—

Abstract

The present invention relates to a cobalamin acquisition protein, compositions containing the cobalamin acquisition protein, and the use of such compositions.

First claim

1 .- 20 . (canceled)

21 . A pharmaceutical composition comprising a protein comprising an amino acid sequence having at least 90% identity with SEQ ID NO: 2, and a pharmaceutically acceptable excipient.

22 . The composition of claim 21 , wherein the protein binds Vitamin B 12 .

23 . The composition of claim 21 , wherein the protein binds Vitamin B 12 with an affinity less than 10 −5 M.

24 . The composition of claim 21 , wherein the composition is a liquid, solid, cream, or paste.

25 . A method of treating a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the composition of claim 21 .

26 . The method of claim 25 , wherein the composition is administered topically or orally to the subject.

27 . The method of claim 25 , wherein the composition is administered non-parenterally to the subject.

28 . The composition of claim 21 , wherein the protein binds Vitamin B 12 with an affinity from about 10 −5 M to about 10 −12 M.

29 . The composition of claim 21 , wherein the composition, when administered to a subject, is capable of reducing the growth and/or proliferation of a microorganism in or on the subject.

30 . The composition of claim 21 , wherein the protein comprises from about 0.1% (w/w) to about 90% (w/w) of the pharmaceutical composition.

31 . The composition of claim 30 , wherein the protein comprises from about 0.5% (w/w) to about 30% (w/w) of the pharmaceutical composition.

Assignees

• Woods Hole Oceanographic Inst

Inventors

• Saito Makoto
• Bertrand Erin M

Classifications

• A61K38/16 Primary

  Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof {(enzyme inhibitors A61K38/005)} · CPC title

• G01N33/82 Primary

  involving vitamins {or their receptors} · CPC title

• C07K14/43504

  from invertebrates · CPC title

• C07K14/405

  from algae · CPC title

• C07K14/00 Primary

  Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof · CPC title