Injection Device with a Needle Cannula

Patent metadata

Field	Value
Publication number	US-2016271319-A1
Application number	US-201415032482-A
Country	US
Kind code	A1
Filing date	Oct 10, 2014
Priority date	Oct 31, 2013
Publication date	Sep 22, 2016
Grant date	—

Abstract

The present invention relates to an injection device for injecting a pharmaceutical liquid drug containing a preservative. The injection device comprises a housing ( 1 ) supporting a cartridge ( 20 ) having an interior chamber ( 21 ) holding the pharmaceutical preservative containing liquid drug to be injected, and a needle cannula ( 10 ) having a front part ( 11 ) and a back part ( 12 ), which back part ( 12 ) is adapted to be in liquid communication with the interior chamber ( 21 ) of the cartridge ( 20 ). The injection device is further provided with a telescopic needle covering shield ( 30 ) which distally is provided with a reservoir ( 31 ) which holds a liquid containing the same preservatives as in the pharmaceutical preservative containing liquid drug contained in the interior chamber of the cartridge. The telescopic needle covering shield ( 30 ) is telescopic movable in relation to the needle cannula ( 10 ) by a first resilient member between a first position and a second position. In the first position, the tip ( 13 ) of the front part ( 11 ) of the needle cannula ( 10 ) is maintained inside the reservoir ( 31 ), and in the second position, the tip ( 13 ) of the front part ( 11 ) of the needle cannula ( 10 ) is located outside the reservoir ( 31 ) and distally to the reservoir ( 31 ). The tip ( 13 ) of the needle cannula ( 10 ) is thus cleaned by the preservatives in the reservoir ( 31 ) between subsequent injections.

First claim

1 . An injection device for injecting a pharmaceutical liquid drug containing a preservative, comprising:
a housing supporting a cartridge having an interior chamber containing the pharmaceutical preservative containing liquid drug to be injected, a needle cannula usable for multiple injections and having a front part with a tip and a back part, which back part is adapted to be in liquid communication with the interior chamber of the cartridge, and a telescopic needle covering shield, which distally is provided with a reservoir confining a predetermined volume of a liquid for cleaning at least the tip of the needle cannula between subsequent injections, and which telescopic needle covering shield is urged distally into a first position by a first resilient member and moved proximally against the bias of the first resilient member into a second position during injection; the first position being a position in which, the tip of the front part of the needle cannula is located inside the reservoir, and the second position being a position in which, the tip of the front part of the needle cannula is located outside the reservoir and distally to the reservoir, and wherein, the predetermined volume of liquid confined in the reservoir of the telescopic needle covering shield contains the same preservative as present in the pharmaceutical preservative containing liquid drug contained in the chamber of the cartridge.

2 . A drug delivery device according to claim 1 , wherein the pharmaceutical preservative comprises phenol, metacresol or any combination thereof.

3 . A drug delivery device according to claim 1 , wherein the identical same pharmaceutical preservative containing liquid drug is present in both the reservoir of the telescopic needle covering shield and in the chamber of the cartridge.

4 . A drug delivery device according to claim 1 , wherein the pharmaceutical preservative containing liquid drug is a blood sugar regulating drug such as insulin, insulin analog, GLP-1 or GLP-2.

5 . A drug delivery device according to claim 1 , wherein the needle cannula is secured in a hub.

6 . A drug delivery device according to claim 5 , wherein the hub is provided with coupling structure for attaching the hub to the injection device.

7 . A drug delivery device according to claim 1 , wherein the reservoir of the telescopic shield distally is provided with a distal septum and proximally with a proximal septum.

8 . A drug delivery device according to claim 7 , wherein the proximal septum of the reservoir is movable relatively to the telescopic shield.

9 . A drug delivery device according to claim 7 , wherein one or both of the distal septum and the proximal septum is provided with a carved-out portion surrounding the tip of the front part of the needle cannula in at least the first position.

10 . A drug delivery device according to claim 1 , wherein the predetermined volume of pharmaceutical preservative containing liquid drug is automatically transferred from the chamber of the cartridge and into the reservoir of the telescopic needle shield.

11 . A drug delivery device according to claim 10 , wherein the proximal septum is automatically moved proximally thereby creating a vacuum inside the reservoir of the telescopic needle shield.

12 . A drug delivery device according to claim 11 , wherein the proximal septum of the reservoir is urged in the proximal direction by a second resilient member.

13 . A drug delivery device according to claim 12 , wherein the proximal septum is secured to an axial movable element which moves axially under influence of the second resilient member.

14 . A drug delivery device according to claim 10 , wherein the injection device automatically ejects a predetermined amount of pharmaceutical preservative containing liquid drug into the reservoir upon first use of the injection device.

15 . A method of preparing the injection device according to claim 3 , the method comprising the steps of:
holding the injection device with the telescopic needle shield in the first position such that the tip of the front part of the needle cannula is located inside the reservoir of the telescopic shield, automatically transferring a predetermined volume of the pharmaceutical preservative containing liquid drug contained inside the chamber of the cartridge into the reservoir of the telescopic shield.

16 . A method according to claim 15 , wherein the transferral into the reservoir of the telescopic needle shield is performed automatically by the second resilient member.

Assignees

• Novo Nordisk As

Inventors

• Bengtsson Henrik
• Eilertsen Lars
• Jensen Casper Bo
• Kirk Frederik Kaae

Classifications

• A61M5/24

  Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic {(ampoules or carpules A61J1/06)} · CPC title

• A61M2005/2474

  with movable piercing means, e.g. ampoule remains fixed or steady · CPC title

• A61M2005/3115

  spring-assisted · CPC title

• A61M5/326

  Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user · CPC title

• A61M5/2466

  by piercing without internal pressure increase (A61M5/2429 takes precedence) · CPC title