Hybrid Corrosion Inhibiting and Bio-Functional Coatings for Magnesium-Based Materials for Development of Biodegradable Metallic Implants

Patent metadata

Field	Value
Publication number	US-2016271301-A1
Application number	US-201415035076-A
Country	US
Kind code	A1
Filing date	Nov 6, 2014
Priority date	Nov 8, 2013
Publication date	Sep 22, 2016
Grant date	—

Abstract

An implantable device and methods of inhibiting corrosion on a magnesium-based implantable device are described. The implantable device comprising a body having an external surface. The body or one or more structural members thereof is formed at least in part by metallic magnesium or an alloy thereof. The implantable device comprises a biocorrosion-inhibiting film on at least a portion of the external surface, wherein the biocorrosion-inhibiting film comprises a metal.

First claim

What is claimed:

1 . An implantable device comprising:
a body having an external surface, said body formed at least in part by metallic magnesium or an alloy thereof; and a biocorrosion-inhibiting film on at least a portion of said external surface, wherein said biocorrosion-inhibiting film comprises a metal.

2 . The implantable device of claim 1 , wherein said body is selected from the group consisting of: screws, plates, nails, pins, rods, hooks, staples, wires, clamps, clips, stents, anchors, porous bone scaffolds, porous cartilage scaffolds, vertebral body replacements, dental implants, and combinations thereof.

3 . The implantable device of claim 1 , wherein said bioconosion-inhibiting film consists essentially of metal.

4 . The implantable device of claim 1 , wherein said metal is biodegradable.

5 . The implantable device of claim 1 , wherein said metal is selected from the group consisting of iron, niobium, titanium, tantalum, zinc, copper, cobalt, chromium, nitinol, combinations thereof, and alloys thereof.

6 . The implantable device of claim 1 , wherein said biocorrosion-inhibiting film is electroplated onto said external surface.

7 . The implantable device of claim 1 , wherein said biocorrosion-inhibiting film is porous.

8 . The implantable device of claim 1 , further comprising:
an intermediate film between said external surface and said biocorrosion-inhibiting film.

9 . The implantable device of claim 8 , wherein said intermediate film comprises a metal.

10 . The implantable device of claim 8 , wherein said intermediate film is non-porous.

11 . The implantable device of claim 8 , further comprising an adhesion promoting film between said external surface and said intermediate film.

12 . The implantable device of claim 11 , wherein said adhesion promoting film is non-porous.

13 . The implantable device of claim 11 , wherein said adhesion promoting film comprises a metal.

14 . The implantable device of claim 1 , further comprising a functional coating on said biocorrosion-inhibiting film.

15 . The implantable device of claim 14 , wherein said functional coating comprises one or more active agents selected from the group consisting of therapeutic agents, antioxidants, anesthetic agents, anti-proliferative agents, osteoinductive agents, osteoconductive agents, and combinations thereof.

16 . The implantable device of claim 15 , wherein said active agent is dispersed in a cattier or matrix.

17 . A method of inhibiting corrosion on a magnesium-based implantable device, said method comprising:
providing a body having an external surface, said body formed at least in part by metallic magnesium or an alloy thereof; and depositing a biocorrosion-inhibiting film on at least a portion of said external surface, wherein said biocorrosion-inhibiting film comprises a metal.

18 . The method of claim 17 , wherein said depositing is selected from the group consisting of electroplating, sputtering and vapor deposition.

19 . The method of claim 17 , wherein said biocorrosion inhibiting film is selectively deposited onto discrete areas of said external surface.

20 . The method of claim 17 , further comprising, before depositing said biocorrosion-inhibiting film:
depositing an optional adhesion promoting film onto said external surface; and depositing an intermediate film onto said adhesion promoting film, wherein said biocorrosion-inhibiting film is deposited onto said intermediate film.

Assignees

• Senthil-Kumar Siddarth
• Univ Wichita State

Inventors

• Mahapatro Anil
• Senthil-Kumar Siddarth

Classifications

• C25D3/40

  from cyanide baths {, e.g. with Cu+} · CPC title

• C23C18/31

  Coating with metals · CPC title

• C23C28/025

  with at least one zinc-based layer · CPC title

• A61L27/047

  Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06 · CPC title

• A61L31/088 Primary

  Other specific inorganic materials not covered by A61L31/084 or A61L31/086 · CPC title