Method of synthesizing a graphene-based antibacterial and using the same

Patent metadata

Field	Value
Publication number	US-2016270403-A1
Application number	US-201615076157-A
Country	US
Kind code	A1
Filing date	Mar 21, 2016
Priority date	Jun 28, 2013
Publication date	Sep 22, 2016
Grant date	—

Abstract

Photothermal antibacterial material RMG is provided in the present invention, where R represents aldehyde, di-aldehyde or multi-aldehyde, M is magnetic material, and G is reduced graphene oxide. A method of synthesizing the abovementioned antibacterial material comprises of three steps. At first graphene oxide was synthesized, followed by simultaneous reduction and functionlization with MNPs and eventually an aldehyde is modified on magnetic material to yield magnetic G functionalized glutaraldehyde (RMG). We utilize the photothermal feature of graphene for antibacterial activity, in addition graphene was functionalized with aldehyde for capturing bacteria and with magnetic material to enhance a focusing of light irradiation. Moreover, the magnetic properties of material could help for reusability of antibacterial material.

First claim

What is claimed is:

1 . A method of synthesizing an antibacterial material RMG for photothermal killing of bacteria by converting light irradiation to emit heat comprising of following steps:
synthesizing a graphene oxide; performing simultaneous reduction and functionalization with a magnetic material; and modifying an aldehyde onto the surface of the magnetic material.

2 . The method according to claim 1 , wherein the step of performing simultaneous reduction and functionalization with a magnetic material further comprises of following steps:
providing an iron-containing solution; providing a suspension containing the graphene oxide; synthesizing the magnetic material; and reducing the graphene oxide.

3 . The method according to claim 2 , wherein the iron/nickel/cobalt-containing solution is a solution containing iron/nickel/cobalt-metal salt mixture.

4 . The method according to claim 1 , wherein the aldehyde is glutaraldehyde or vancomycin or deptomycin.

5 . A method of using an antibacterial material comprising of following steps:
interacting the antibacterial material RMG with bacteria, thereby capturing the bacteria with the antibacterial material; and irradiating the antibacterial material and captured bacteria with a light source, wherein R is aldehyde, di-aldehyde, or multi-aldehyde, M is a magnetic material, and G is reduced graphene oxide.

6 . The method according to claim 5 , further comprising the following steps:
after the step of interacting the antibacterial material, utilizing a magnet to attract the antibacterial material along with the captured bacteria, before irradiating the antibacterial material and the captured bacteria with the light source.

7 . The method according to claim 5 , wherein the light source is a visible/near infrared light source.

8 . The method according to claim 5 , wherein M is iron/nickel/cobalt metal nanoparticles, and R is glutaraldehyde/vancomycin/deptomycin.

Assignees

• Nat Univ Tsing Hua

Inventors

• Ling Yong-Chien
• Wu Meng-Chin

Classifications

• C07F15/02

  Iron compounds · CPC title

• A01N55/02 Primary

  containing metal atoms · CPC title

• A61L2/088

  using photocatalysts or photosensitisers · CPC title

• A61L2202/11

  Apparatus for generating biocidal substances, e.g. vaporisers, UV lamps · CPC title

• A01N35/10 Primary

  containing a carbon-to-nitrogen double bond · CPC title