Methods for Diagnosing Pervasive Development Disorders, Dysautonomia and Other Neurological Conditions

Patent metadata

Field	Value
Publication number	US-2016266113-A1
Application number	US-201615164493-A
Country	US
Kind code	A1
Filing date	May 25, 2016
Priority date	Nov 16, 2000
Publication date	Sep 15, 2016
Grant date	—

Abstract

Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death Syndrome). In one aspect, a diagnosis method comprises analyzing a stool sample of an individual for the presence of a biological marker (or marker compound) comprising one or more pathogens, which provides an indication of whether the individual has, or can develop, a disorder including, but not limited to, a PDD, Dysautonomia, Parkinsons disease and SIDS. Preferably, the presence of one or more pathogens is determined using a stool immunoassay to determine the presence of antigens in a stool sample, wherein such antigens are associated with one or more pathogens including, but not limited to, Giardia, Cryptosporidium, E. histolytica, C. difficile , Adenovirus, Rotavirus or H. pylori.

First claim

What is claimed is:

1 . A method for determining if an individual has, or can develop, a disorder or condition, comprising the steps of:
obtaining a stool sample from the individual; analyzing the stool sample to determine the presence of a pathogen; and correlating the presence of a pathogen with a disorder or lack thereof.

2 . The method of claim 1 , wherein the step of analyzing comprises performing a stool immunoassay to determine the presence of an antigen associated with a pathogen.

3 . The method of claim 1 , wherein the disorder comprises a PDD (pervasive development disorder).

4 . The method of claim 1 , wherein the disorder comprises a dysautonomic disorder.

5 . The method of claim 1 , wherein the disorder comprises Parkinson's disease.

6 . The method of claim 1 , wherein the disorder comprises a neurological disorder.

7 . The method of claim 1 , wherein the pathogen comprises Helicobacter pylori.

8 . The method of claim 1 , wherein the pathogen comprises Clostridium difficile.

9 . The method of claim 1 , wherein the pathogen comprises Cryptosporidium.

10 . The method of claim 1 , wherein the pathogen comprises Giardia.

11 . The method of claim 1 , wherein the pathogen comprises Rotavirus or Adenovirus.

12 . The method of claim 1 , wherein the pathogen comprises Entamoeba histolytica.

13 . A biological marker for determining if an individual has, or can develop, a disorder or condition, the biological marker comprising a pathogen in a stool sample of the individual.

14 . The biological marker of claim 13 , wherein the presence of the pathogen in the stool sample is determined using stool immunoassay.

15 . The biological marker of claim 13 , wherein the pathogen comprises Helicobacter pylori.

16 . The biological marker of claim 13 , wherein the pathogen comprises Clostridium difficile.

17 . The biological marker of claim 13 , wherein the pathogen comprises Cryptosporidium.

18 . The biological marker of claim 13 , wherein the pathogen comprises Giardia.

19 . The biological marker of claim 13 , wherein the pathogen comprises Rotavirus or Adenovirus.

20 . The biological marker of claim 13 , wherein the pathogen comprises Entamoeba histolytica.

Assignees

• Curemark Llc

Inventors

• Fallon Joan M

Classifications

• G01N2469/10

  Detection of antigens from microorganism in sample from host · CPC title

• G01N2800/28

  Neurological disorders · CPC title

• G01N2800/2835

  Movement disorders, e.g. Parkinson, Huntington, Tourette · CPC title

• G01N33/56983

  Viruses · CPC title

• G01N33/56911 Primary

  Bacteria · CPC title