Liquid Mixing Device, and Liquid Chromatography Apparatus

Patent metadata

Field	Value
Publication number	US-2016266078-A1
Application number	US-201415028492-A
Country	US
Kind code	A1
Filing date	Dec 19, 2014
Priority date	Jan 9, 2014
Publication date	Sep 15, 2016
Grant date	—

Abstract

A liquid-mixing device that minimizes solvent leakage and reduces creep of or damage to the component parts of said liquid-mixing device even at ultrahigh pressures of 100 MPa and up. Also, a liquid chromatography device using said quid-mixing device. Said liquid chromatography device is provided with a supply pump that supplies a plurality of different solutions, a liquid-mixing device that mixes the supplied solutions, a sample injection device that injects a sample into the mixture of solutions, a column that separates the components of the injected sample, and a detector that detects the separated components. The liquid-mixing device has an inlet-side connector through which the plurality of different solutions flow in, a liquid-mixing section in which said solutions are mixed, and an outflow-side connector through which the mixed solutions flow out. The inlet-side connector and the liquid-mixing section are directly bonded to each other via diffusion bonding, as are the liquid-mixing section and the exit-side connector.

First claim

1 .- 9 . (canceled)

10 . A liquid chromatography apparatus, comprising:
a feed pump for feeding a plurality of kinds of solutions; a liquid mixing device for mixing the solutions fed by the feed pump; a sample injection device for injecting a sample in the solutions mixed in the liquid mixing device; a column for separating components of the sample injected by the sample injection device; and a detector for detecting the components separated in the column, wherein: the liquid mixing device includes an inlet side connector portion having, on one end side, a groove for a first connector for a pipe to be connected to the feed pump so that the plurality of kinds of solutions fed by the feed pump flow into the inlet side connector portion, a liquid mixing portion for mixing the solutions that have flowed into the inlet side connector portion, and an outlet side connector portion having, on one end side, a groove for a second connector for a pipe to be connected to the sample injection device so that the solutions mixed in the liquid mixing portion flow into the sample injection device; and the other end side of the inlet side connector portion and one end side of the liquid mixing portion are directly bonded by diffusion bonding, and the other end side of the liquid mixing portion and the other end side of the outlet side connector portion are directly bonded by diffusion bonding.

11 . The liquid chromatography apparatus according to claim 10 , wherein:
a groove having a smaller diameter than a diameter of the groove for the first connector is provided on the other end side of the inlet side connector portion; and a groove having a smaller diameter than a diameter of the groove for the second connector is provided on the other end side of the outlet side connector portion.

12 . The liquid chromatography apparatus according to claim 10 , wherein
the liquid mixing portion is formed by laminating substrate-like members in which a plurality of kinds of grooves are formed.

13 . The liquid chromatography apparatus according to claim 12 , wherein
the liquid mixing portion is formed by laminating substrate-like members in which a plurality of kinds of spiral grooves are formed.

14 . A liquid chromatography apparatus, comprising:
a liquid mixing device for mixing a plurality of kinds of solutions; a feed pump for feeding the solutions mixed in the liquid mixing device; a sample injection device for injecting a sample in the solutions fed by the feed pump; a column for separating components of the sample injected by the sample injection device; and a detector for detecting the components separated in the column, wherein: the liquid mixing device includes an inlet side connector portion having, on one end side, a groove for a first connector for a pipe to be connected to the plurality of kinds of solutions so that the plurality of kinds of solutions flow into the inlet side connector portion, a liquid mixing portion for mixing the solutions that have flowed into the inlet side connector portion, and an outlet side connector portion having, on one end side, a groove for a second connector for a pipe to be connected to the feed pump so that the solutions mixed in the liquid mixing portion flow into the feed pump; and the other end side of the inlet side connector portion and one end side of the liquid mixing portion are directly bonded by diffusion bonding, and the other end side of the liquid mixing portion and the other end side of the outlet side connector portion are directly bonded by diffusion bonding.

15 . The liquid chromatography apparatus according to claim 14 , wherein:
a groove having a smaller diameter than a diameter of the groove for the first connector is provided on the other end side of the inlet side connector portion; and a groove having a smaller diameter than a diameter of the groove for the second connector is provided on the other end side of the outlet side connector portion.

16 . The liquid chromatography apparatus according to claim 14 , wherein
the liquid mixing portion is formed by laminating substrate-like members in which a plurality of kinds of grooves are formed.

17 . The liquid chromatography apparatus according to claim 16 , wherein
the liquid mixing portion is formed by laminating substrate-like members in which a plurality of kinds of spiral grooves are formed.

18 . A liquid mixing device for a liquid chromatography apparatus, comprising:
an inlet side connector portion having, on one end side, a groove for a first connector for connecting a pipe so that the plurality of kinds of solutions flow into the inlet side connector portion; a liquid mixing portion for mixing the solutions that have flowed into the inlet side connector portion; and an outlet side connector portion having, on one end side, a groove for a second connector for connecting a pipe so that the solutions mixed in the liquid mixing portion flow downstream, wherein the other end side of the inlet side connector portion and one end side of the liquid mixing portion are directly bonded by diffusion bonding, and the other end side of the liquid mixing portion and the other end side of the outlet side connector portion are directly bonded by diffusion bonding.

19 . The liquid mixing device according to claim 18 , wherein
a groove having a smaller diameter than a diameter of the groove for the first connector is provided on the other end side of the inlet side connector portion; and a groove having a smaller diameter than a diameter of the groove for the second connector is provided on the other end side of the outlet side connector portion.

20 . The liquid mixing device according to claim 18 , wherein
the liquid mixing portion is formed by laminating substrate-like members in which a plurality of kinds of grooves are formed.

21 . The liquid mixing device according to claim 20 , wherein
the liquid mixing portion is formed by laminating substrate-like members in which a plurality of kinds of spiral grooves are formed.

Assignees

• Hitachi High Tech Corp

Inventors

• ONODA Yugo
• Tomida Shoji
• Sugimoto Kouichi
• Yagi Takashi
• Watanabe Tetsuya

Classifications

• G01N30/34 Primary

  of fluid composition, e.g. gradient (G01N30/36 takes precedence) · CPC title

• G01N30/16

  Injection (G01N30/24 takes precedence) · CPC title

• G01N2030/347

  mixers · CPC title

• B01F5/0668

  Operations & Transport · mapped topic

• B01F15/00662

  Operations & Transport · mapped topic