Biologic replacement for fibrin clot

Patent metadata

Field	Value
Publication number	US-2016263279-A1
Application number	US-201615066482-A
Country	US
Kind code	A1
Filing date	Mar 10, 2016
Priority date	Jun 22, 1999
Publication date	Sep 15, 2016
Grant date	—

Abstract

The invention provides composition and methods for repairing a ruptured anterior cruciate ligament.

First claim

1 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises plasma.

2 . The scaffold according to claim 1 , wherein the tissue defect is extra-articular.

3 . The scaffold according to claim 1 , wherein said tissue defect is intra-articular.

4 . The scaffold according to claim 1 , wherein said tissue defect comprises a ligament.

5 . The scaffold according to claim 1 , wherein said tissue defect comprises a tendon.

6 . The scaffold according to claim 1 , wherein said tissue defect comprises bone.

7 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a platelet.

8 . The scaffold according to claim 7 , wherein said tissue defect is extra-articular.

9 . The scaffold according to claim 7 , wherein said tissue defect is intra-articular.

10 . The scaffold according to claim 7 , wherein said tissue defect comprises a ligament.

11 . The scaffold according to claim 7 , wherein said tissue defect comprises a tendon.

12 . A scaffold for repair of a tissue defect in comprising a three-dimensional matrix adapted to facilitate cell in-growth, wherein said matrix is shaped for implantation into a patient at the site of the tissue defect, wherein said matrix comprises a natural matrix material wherein the natural matrix material is a collagen glycosaminoglycan copolymer comprised of collagen type I, and wherein said scaffold further comprises a neutralizing agent.

13 . The scaffold according to claim 12 , wherein said tissue defect is extra-articular.

14 . The scaffold according to claim 12 , wherein said tissue defect is intra-articular.

15 . The scaffold according to claim 12 , wherein said tissue defect is a partial or complete tear of a ligament.

16 . The scaffold according to claim 12 , wherein said tissue defect is a partial or complete tear of an anterior cruciate ligament (ACL).

17 . The scaffold according to claim 12 , wherein said tissue defect is a partial or complete tear of the rotator cuff.

18 . The scaffold according to claim 12 , wherein said tissue defect is a partial or complete tear of the labrum.

19 . The scaffold according to claim 12 , wherein said tissue defect is a partial or complete tear of the meniscus.

Assignees

• Children'S Medical Center Corp

Inventors

• Murray Martha M
• Murray Michael F
• Marler Jennifer

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P41/00

  Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L27/3843

  Connective tissue · CPC title