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Folate Receptor Binding Conjugates of Antifolates
US2016263237A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016263237-A1 |
| Application number | US-201514919518-A |
| Country | US |
| Kind code | A1 |
| Filing date | Oct 21, 2015 |
| Priority date | Sep 17, 2008 |
| Publication date | Sep 15, 2016 |
| Grant date | — |
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Abstract
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Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
First claim
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1 - 23 . (canceled) 24 . A conjugate of formula ALD m , wherein A is an antifolate of the formula: wherein (1) X=OH, R=H, and Y=Glu; or (2) X=OCH 3 , R=H, and Y=Glu; or (3) X=OH, R=H, and Y=Valine; or (4) X=OH, R=H, and Y=Suberate; or (5) X=OH, R=CH 3 , and Y=Glu; m is 1 to 3; D is an independently…
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Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
Human Necessities · mapped topic
- A61K31/475Primary
Human Necessities · mapped topic
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- What does patent US2016263237A1 cover?
- Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
- Who is the assignee on this patent?
- Purdue Research Foundation, Endocyte Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/475. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu Sep 15 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).