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Ph-responsive nanoparticle using mussel adhesive protein for drug delivery and method for preparing the same
US2016263136A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016263136-A1 |
| Application number | US-201615000551-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jan 19, 2016 |
| Priority date | Mar 13, 2015 |
| Publication date | Sep 15, 2016 |
| Grant date | — |
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Abstract
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The present invention relates to a pH-responsive metal-catechol derivative nanoparticle for drug delivery based on a mussel adhesive protein, particularly Fe(III)-DOPA nanoparticle, and a method for preparing the same. A nanoparticle for drug delivery according to the present invention is prepared using a pH responsive substance, catechol derivative-metal complex, particularly Fe(III)-DOPA complex, based on a mussel adhesive protein. Thereby, the present invention has excellent biocompatibility, is capable of easily and quickly penetrating into a target cell, and releases a loaded drug under acidic conditions, which enables to selectively deliver a drug to a specific disease having an acidic environment.
First claim
Opening claim text (preview).
What is claimed is: 1 . A pH-responsive nanoparticle for drug delivery, comprising: a catechol derivative; a metal capable of forming a coordinate bond with the catechol derivative; and a drug. 2 . The nanoparticle of claim 1 , wherein the catechol derivative is formed by converting a tyrosine residue of a mussel adhesive protein. 3 . The nanoparticle of claim 2 , wherein the mussel adhesive protein comprises an amino acid sequ…
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Human Necessities · mapped topic
Human Necessities · mapped topic
- A61K31/704Primary
Human Necessities · mapped topic
- A61K47/6929Primary
Human Necessities · mapped topic
Human Necessities · mapped topic
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- What does patent US2016263136A1 cover?
- The present invention relates to a pH-responsive metal-catechol derivative nanoparticle for drug delivery based on a mussel adhesive protein, particularly Fe(III)-DOPA nanoparticle, and a method for preparing the same. A nanoparticle for drug delivery according to the present invention is prepared using a pH responsive substance, catechol derivative-metal complex, particularly Fe(III)-DOPA comp…
- Who is the assignee on this patent?
- Postech Academy-Industry Found
- What technology area does this patent fall under?
- Primary CPC classification A61K31/704. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu Sep 15 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).