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Methods and compositions for localized agent delivery
US2016256386A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016256386-A1 |
| Application number | US-201615015464-A |
| Country | US |
| Kind code | A1 |
| Filing date | Feb 4, 2016 |
| Priority date | Nov 24, 2008 |
| Publication date | Sep 8, 2016 |
| Grant date | — |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
First claim
Opening claim text (preview).
1 . A biodegradable nanoparticle comprising maleimide groups on its exterior surface. 2 . The nanoparticle of claim 1 , wherein the nanoparticle further comprises a lipid bilayer surface. 3 . The nanoparticle of claim 1 , wherein the nanoparticle comprises a poly(lactide-co-glycolide) (PLGA) core. 4 . The nanoparticle of claim 1 , wherein the nanoparticle further comprises an agent. 5 . The nanoparticle of claim 1 , wherein the nanoparticle further comprises a plurality of agents. 6 . The nanoparticle of claim 4 , wherein the agent is an antibody. 7 . The nanoparticle of claim 4 , wherein the agent is an antigen. 8 . The nanoparticle of claim 4 , wherein the agent is an adjuvant. 9 . The nanoparticle of claim 8 , wherein the adjuvant is a TLR ligand. 10 . The nanoparticle of claim 4 , wherein the agent is a nucleic acid. 11 . The nanoparticle of claim 10 , wherein the nucleic acid is an siRNA. 12 . The nanoparticle of claim 4 , wherein the agent is an anti-cancer agent. 13 . The nanoparticle of claim 4 , wherein the agent is a cytokine. 14 . The nanoparticle of claim 4 , wherein the agent is an interleukin. 15 . The nanoparticle of claim 5 , wherein the plurality of agents comprises an antigen and an adjuvant. 16 . The nanoparticle of claim 5 , wherein the plurality of agents comprises an adjuvant and an anti-cancer agent. 17 . The nanoparticle of claim 1 , wherein the nanoparticle is 50-500 nanometers in diameter. 18 . The nanoparticle of claim 1 , wherein the nanoparticle is about 150 nanometers in diameter. 19 . The nanoparticle of claim 1 , in a lyophilized form.
Assignees
Inventors
Classifications
the polymer being PLGA, PLA or polyglycolic acid · CPC title
the form being a liposome · CPC title
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title
interfering nucleic acids [NA] · CPC title
Haematopoietic stem cells; Uncommitted or multipotent progenitors · CPC title
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Frequently asked questions
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- What does patent US2016256386A1 cover?
- The invention provides compositions and methods for delivering agents to localized regions, tissues, or organs in vivo by conjugating agent-loaded nanoparticles to cells having homing capability. The agents may be therapeutic or diagnostic agents such as cancer chemotherapeutic agents and imaging agents respectively.
- Who is the assignee on this patent?
- Massachusetts Inst Technology
- What technology area does this patent fall under?
- Primary CPC classification A61K9/127. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu Sep 08 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).