Methods for treating hair loss disorders

Patent metadata

Field	Value
Publication number	US-2016256374-A1
Application number	US-201615066554-A
Country	US
Kind code	A1
Filing date	Mar 10, 2016
Priority date	Nov 2, 2010
Publication date	Sep 8, 2016
Grant date	—

Abstract

The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.

First claim

What is claimed:

1 . A method of treating a hair-loss disorder in a mammalian subject in need thereof, the method comprising administering to the subject an effective amount of an inhibitor of Janus Kinase (Jak)1, Jak2, or Jak3, wherein said inhibitor is VX-509.

2 . A method for inducing hair growth in a subject, the method comprising:
(a) administering to the subject an effective amount of a Jak1, Jak2, or Jak3 inhibitor, wherein said inhibitor is VX-509, thereby inducing hair growth in the subject.

3 . The method of claim 1 , wherein the hair-loss disorder comprises androgenetic alopecia, telogen effluvium, alopecia areata, telogen effluvium, tinea capitis, hypotrichosis, or hereditary hypotrichosis simplex.

4 . The method of claim 3 , wherein the alopecia areata is alopecia totalis or alopecia universalis.

5 . The method of claim 2 , wherein the subject suffers from a hair-loss disorder, wherein the hair-loss disorder is selected from—androgenetic alopecia, telogen effluvium, alopecia areata, telogen effluvium, tinea capitis, hypotrichosis, and hereditary hypotrichosis simplex.

6 . The method of claim 5 , wherein the alopecia areata is alopecia totalis or alopecia universalis.

7 . The method of claim 1 wherein the hair loss-disorder is androgenetic alopecia.

8 . The method of claim 1 wherein the hair loss-disorder is alopecia areata.

9 . The method of claim 5 wherein the hair loss-disorder is androgenetic alopecia.

10 . The method of claim 5 wherein the hair loss-disorder is alopecia areata.

Assignees

• Univ Columbia

Inventors

• Christiano Angela M
• Clynes Raphael

Classifications

• A61K31/277

  having a ring, e.g. verapamil · CPC title

• A61Q7/00

  Preparations for affecting hair growth · CPC title

• A61K8/64

  Proteins; Peptides; Derivatives or degradation products thereof · CPC title

• A61K2800/782

  Enzyme inhibitors; Enzyme antagonists · CPC title

• A61K31/553

  having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine · CPC title