Shape memory polymer intraocular lenses

Patent metadata

Field	Value
Publication number	US-2016256264-A1
Application number	US-201615157214-A
Country	US
Kind code	A1
Filing date	May 17, 2016
Priority date	Mar 7, 2011
Publication date	Sep 8, 2016
Grant date	—

Abstract

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45

First claim

1 .- 39 . (canceled)

40 . A method of implanting an intraocular lens device comprising making an incision in a cornea or sclera less than or equal to 1.8 mm wide; and inserting an intraocular lens into the capsular bag through the incision,
wherein the intraocular lens device is formed of a shape memory polymer that comprises tert-butyl acrylate and poly(ethylene glycol)dimethacrylate, wherein the intraocular lens device is implanted in a compressed and deformed configuration, wherein the intraocular lens device recovers its non-deformed configuration with a recovery rate of between 0.25 seconds and 600 seconds, and wherein the intraocular lens device has a rubbery modulus of 250 kPa to 20,000 kPa.

41 . The method of claim 40 , wherein the poly(ethylene glycol)dimethacrylate has a molecular weight substantially between 500 and 2000, inclusive.

42 . The method of claim 40 , wherein the shape memory polymer further comprises butyl acrylate.

43 . The method of claim 40 , wherein the shape memory polymer comprises 50 weight percent tert-butyl acrylate, 28 weight percent isobutyl acrylate, and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

44 . The method of claim 40 , wherein the shape memory polymer comprises 78 weight percent tert-butyl acrylate and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

45 . The method of claim 40 , wherein the shape memory polymer comprises 65 weight percent tert-butyl acrylate, 13 weight percent butyl acrylate, and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

46 . The method of claim 40 , wherein the intraocular lens device has a refractive index above 1.45; a Tg between 10° C. and 60° C., inclusive; de minimis or an absence of glistening; and substantially 100% transmissivity of light in the visible spectrum.

47 . The method of claim 40 , wherein the intraocular lens device is formed of a shape memory polymer that consists essentially of tert-butyl acrylate, poly(ethylene glycol)dimethacrylate, and optionally an additional monomer selected from the group consisting of isobutyl acrylate and butyl acrylate.

48 . A method of implanting an intraocular lens device comprising making an incision in a cornea or sclera less than or equal to 1.8 mm wide; and inserting an intraocular lens into the ciliary sulcus through the incision,
wherein the intraocular lens device is formed of a shape memory polymer that comprises tert-butyl acrylate and poly(ethylene glycol)dimethacrylate, wherein the intraocular lens device is implanted in a compressed and deformed configuration, wherein the intraocular lens device recovers its non-deformed configuration with a recovery rate of between 0.25 seconds and 600 seconds, and wherein the intraocular lens device has a rubbery modulus of 250 kPa to 20,000 kPa.

49 . The method of claim 48 , wherein the poly(ethylene glycol)dimethacrylate has a molecular weight substantially between 500 and 2000, inclusive.

50 . The method of claim 48 , wherein the shape memory polymer further comprises butyl acrylate.

51 . The method of claim 48 , wherein the shape memory polymer comprises 50 weight percent tert-butyl acrylate, 28 weight percent isobutyl acrylate, and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

52 . The method of claim 48 , wherein the shape memory polymer comprises 78 weight percent tert-butyl acrylate and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

53 . The method of claim 48 , wherein the shape memory polymer comprises 65 weight percent tert-butyl acrylate, 13 weight percent butyl acrylate, and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

54 . The method of claim 48 , wherein the intraocular lens device has a refractive index above 1.45; a Tg between 10° C. and 60° C., inclusive; de minimis or an absence of glistening; and substantially 100% transmissivity of light in the visible spectrum.

55 . The method of claim 48 , wherein the intraocular lens device is formed of a shape memory polymer that consists essentially of tert-butyl acrylate, poly(ethylene glycol)dimethacrylate, and optionally an additional monomer selected from the group consisting of isobutyl acrylate and butyl acrylate.

56 . A method of implanting an intraocular lens device comprising making an incision into a cornea less than or equal to 1.8 mm wide to access the anterior chamber; and inserting an intraocular lens into the anterior chamber through the incision,
wherein the intraocular lens device is formed of a shape memory polymer that comprises tert-butyl acrylate and poly(ethylene glycol)dimethacrylate, wherein the intraocular lens device is implanted in a compressed and deformed configuration, wherein the intraocular lens device recovers its non-deformed configuration with a recovery rate of between 0.25 seconds and 600 seconds, and wherein the intraocular lens device has a rubbery modulus of 250 kPa to 20,000 kPa.

57 . The method of claim 56 , wherein the poly(ethylene glycol)dimethacrylate has a molecular weight substantially between 500 and 2000, inclusive.

58 . The method of claim 56 , wherein the shape memory polymer further comprises butyl acrylate.

59 . The method of claim 56 , wherein the shape memory polymer comprises 50 weight percent tert-butyl acrylate, 28 weight percent isobutyl acrylate, and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

60 . The method of claim 56 , wherein the shape memory polymer comprises 78 weight percent tert-butyl acrylate and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

61 . The method of claim 56 , wherein the shape memory polymer comprises 65 weight percent tert-butyl acrylate, 13 weight percent butyl acrylate, and 22 weight percent poly(ethylene glycol)dimethacrylate 1000.

62 . The method of claim 56 , wherein the intraocular lens device has a refractive index above 1.45; a Tg between 10° C. and 60° C., inclusive; de minimis or an absence of glistening; and substantially 100% transmissivity of light in the visible spectrum.

63 . The method of claim 56 , wherein the intraocular lens device is formed of a shape memory polymer that consists essentially of tert-butyl acrylate, poly(ethylene glycol)dimethacrylate, and optionally an additional monomer selected from the group consisting of isobutyl acrylate and butyl acrylate.

64 . A method of implanting an intracorneal implant device comprising making an incision into a cornea less than or equal to 1.8 mm wide to create a tunnel in the cornea; and inserting an intracorneal implant device into the anterior chamber through the incision,
wherein the intracorneal implant device is formed of a shape memory polymer that comprises tert-butyl acrylate and poly(ethylene glycol)dimethacrylate, wherein the intracorneal implant device is implanted in a compressed and deformed configuration, wherein the intracorneal implant device recovers its non-deformed configuration with a recovery rate of between 0.25 seconds and 600 seconds, and wherein the intracorneal implant device has a rubbery modulus of 250 kPa to 20,000 kPa.

65 . The method of claim 64 , wherein the poly(ethylene glycol)dimethacrylate has a molecular weight substantially between 500 and 2000, inclusive.

66 . The method of claim 64 , wherein the shape memory polymer further comprises butyl acrylate.

67 . The method of

Assignees

• Univ Colorado Regents

Inventors

• Kahook Malik Y
• Mandava Naresh
• Shandas Robin
• Rech Bryan

Classifications

• B29C69/025

  Deforming articles in a simpler intermediate shape without internal stresses for packaging transporting or storage and reshaping and fixing the original configuration on the place of use (shaping by liberation of internal stresses B29C61/00) · CPC title

• B29L2031/7532

  Artificial members, protheses · CPC title

• A61L27/16 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61F2002/169

  Surrounding optic · CPC title

• A61F2002/1683

  having filiform haptics · CPC title