Devices and methods for removal of acute blockages from blood vessels

Patent metadata

Field	Value
Publication number	US-2016256180-A1
Application number	US-201615158384-A
Country	US
Kind code	A1
Filing date	May 18, 2016
Priority date	Jun 13, 2014
Publication date	Sep 8, 2016
Grant date	—

Abstract

A rapid exchange (RX) catheter may provide a proximal seal against a guide catheter inner lumen so that aspiration may be applied through a guide catheter. The catheter may include an exit port that defines a transfer port for aspiration and may enable minimal frictional engagement with the guide catheter proximal of the exit port. Aspiration can be applied to the lumen of the guide catheter and may be directed to and effective at the tip of the RX aspiration catheter. A tip of the RX catheter may facilitate aspiration and retrieval of the clot by expanding under load and can also partially or fully occlude the vessel.

First claim

1 - 49 . (canceled)

50 . A method of removing clot from a vessel, the method comprising:
advancing a microcatheter relative to a clot such that a distal end of the microcatheter extends distally of or within the clot; unsheathing an expandable clot engaging device; positioning a distal end of a second catheter proximal of the clot; retracting the second catheter to unsheath a self-expandable clot receptor device, the clot receptor device including a proximal end and a distal end, wherein, upon being unsheathed, the distal end of the clot receptor device includes a larger diameter than a diameter of the proximal end of the clot receptor device and larger than a diameter of the distal end of the second catheter; and retracting the clot engaging device toward the clot receptor device.

51 . The method of claim 50 , further including:
sealing the distal end of the clot receptor device against the vessel.

52 . The method of claim 50 , further including:
aspirating through a lumen of the second catheter.

53 . The method of claim 52 , further including:
maintaining the vessel in an open state during aspiration, via the distal end of the clot receptor device.

54 . The method of claim 50 , wherein retracting the clot engaging device toward the clot receptor device includes retracting the clot engaging device through the distal end of the clot receptor device and into a lumen defined by the clot receptor device.

55 . The method of claim 54 , further including:
retracting the clot receptor device into a lumen of the second catheter.

56 . The method of claim 50 , wherein retracting the second catheter to unsheath the self-expandable clot receptor device includes expanding the distal portion of the clot receptor device to a diameter between 50% and 500% larger than a diameter of the proximal end of the clot receptor device.

57 . The method of claim 50 , further including:
preventing clot flow proximally of clot receptor device via the distal end of the clot receptor device.

58 . The method of claim 50 , wherein the clot receptor device comprises a self-expanding frame and a non-porous cover positioned over the self-expanding frame.

59 . A system for removing a clot from a vessel, the system comprising:
an expandable clot retrieval device having a collapsed delivery configuration and an expanded deployed configuration; a microcatheter having a proximal end and a distal end and defining a lumen therein, the expandable clot retrieval device being positioned within the lumen of the microcatheter in the collapsed delivery configuration; a second catheter having a proximal end and a distal end and defining a lumen therein; a self-expandable clot receptor device having a sheathed configuration within the lumen of the second catheter and expanded configuration extending distally of the second catheter, wherein, in the expanded configuration, a distal end of the clot receptor device includes a larger diameter than a diameter of a proximal end of the clot receptor device and larger than a diameter of the distal end of the second catheter.

60 . The system of claim 59 , wherein the clot receptor device further includes a non-porous cover positioned over a self-expanding frame.

61 . The system of claim 59 , wherein the non-porous membrane comprises a polymeric material.

62 . The system of claim 59 , wherein, in the expanded configuration, the distal end of the clot receptor device includes diameter that is between 50% and 500% larger than the diameter of the proximal end of the clot receptor device.

63 . The system of claim 59 , wherein, in the expanded configuration, the distal end of the clot receptor device seals against the vessel.

64 . A method of removing clot from a vessel, the method comprising:
advancing a microcatheter to relative to a clot such that a distal end of the microcatheter extends distally of or within the clot; unsheathing an expandable clot engaging device; positioning a distal end of a second catheter proximal of the clot; retracting the second catheter to unsheath a self-expandable clot receptor device, the clot receptor device including a proximal end and a distal end, wherein, upon being unsheathed, the distal end of the clot receptor device includes a larger diameter than a diameter of the proximal end of the clot receptor device and larger than a diameter of the distal end of the second catheter; sealing the distal end of the clot receptor device against the vessel; and retracting the clot engaging device through the distal end of the clot receptor device and into a lumen defined by the clot receptor device.

65 . The method of claim 64 , further including:
retracting the clot receptor device into a lumen of the second catheter.

66 . The method of claim 64 , wherein retracting the second catheter to unsheath the self-expandable clot receptor device includes expanding the distal portion of the clot receptor device to a diameter between 50% and 500% larger than a diameter of the proximal end of the clot receptor device.

67 . The method of claim 64 , further including:
aspirating through a lumen of the second catheter.

68 . The method of claim 67 , further including:
maintaining the vessel in an open state during aspiration, via the distal end of the clot receptor device.

69 . The method of claim 64 , wherein the clot receptor device comprises a self-expanding frame and a non-porous cover positioned over the self-expanding frame.

Assignees

• Neuravi Ltd

Inventors

• Vale David
• Casey Brendan
• Gilvarry Michael
• Mcardle Kevin
• Holian Maeve
• Hardiman David
• Keane Alan
• King Daniel

Classifications

• A61B2017/2215

  having an open distal end · CPC title

• A61B2017/22067

  Blocking; Occlusion (A61B2017/22054 takes precedence) · CPC title

• A61B2017/3435

  using everted sleeves · CPC title

• A61B17/22

  Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for · CPC title

• A61B2017/00778

  Operations on blood vessels (A61B2017/22097, A61B2017/320741 take precedence) · CPC title