X-ray breast tomosynthesis enhancing spatial resolution including in the thickness direction of a flattened breast

Patent metadata

Field	Value
Publication number	US-2016256125-A1
Application number	US-201415027650-A
Country	US
Kind code	A1
Filing date	Oct 9, 2014
Priority date	Oct 5, 2010
Publication date	Sep 8, 2016
Grant date	—

Abstract

Systems and methods for breast x-ray tomosynthesis that enhance spatial resolution in the direction in which the breast is flattened for examination. In addition to x-ray data acquisition of 2D projection tomosynthesis images ETp 1 over a shorter source trajectory similar to known breast tomosynthesis, supplemental 2D images ETp 2 are taken over a longer source trajectory and the two sets of projection images are processed into breast slice images ETr that exhibit enhanced spatial resolution, including in the thickness direction of the breast. Additional features include breast CT of an upright patient's flattened breast, multi-mode tomosynthesis, and shielding the patient from moving equipment.

First claim

1 . An x-ray breast imaging system comprising:
a breast immobilizer configured to flatten a patient's breast; an x-ray source and an x-ray imaging receptor configured to image the breast in an enhanced tomosynthesis mode ET in which the receptor obtains respective two-dimensional (2D) projection tomosynthesis x-ray images ETp 1 in the course of a first trajectory of the source around the immobilizer and images ETp 2 in the course of a longer second trajectory of the source around the immobilizer; a computer-implemented image processor configured to apply tomosynthesis image reconstruction processing to the images ETp 1 and ETp 2 to obtain reconstructed images ETr to which the ETp 1 images contribute more high spatial frequency content than the ETp 2 images and which represent respective breast slices having selected thicknesses and orientations; and a display configured to display images related to said 3D reconstructed image.

2 . The system of claim 1 in which the source and receptor are further configured to alternatively operate in a tomosynthesis mode T in which the source moves only in the first trajectory and only the images Tp 1 are obtained and processed into breast slice images.

3 . The system of claim 1 in which the source and receptor are further configured to alternatively operate in a mammography mode M in which the source and receptor remain in fixed positions relative to the breast immobilizer while the receptor generates an x-ray mammogram Mp.

4 . The system of claim 1 in which the source and receptor are further configured to rotate around the breast immobilizer while the receptor generates a multiplicity of CT projection images CTp.

5 . The system of claim 1 in which both the source and the receptor are configured to move around the breast immobilizer in the course of the receptor obtaining the ETp 2 images, and further including a patient shield configured to enclose the moving source and receptor.

6 . The system of claim 1 including a patient shield that surrounds the first and second trajectories and has a central opening in which the breast immobilizer is located, wherein the central opening is sufficiently large for a patient to insert her arm therein such that at least a significant portion of the patient axilla enters an imaging volume when the patient's breast is flattened in the breast immobilizer.

7 . The system of claim 6 in which the breast immobilizer is configured to move radially within the central opening from a central position to a position nearer a circumferential periphery of the central opening and closer to the receptor.

8 . The system of claim 1 including a patient shield that surrounds the first and second trajectories of the source and has an opening for the patient's lower body within an arc outside the source trajectories.

9 . The system of claim 1 in which the first trajectory is over an arc of 7.5°-50° and the second trajectory is over an arc of 50°-250°.

10 . The system of claim 1 in which the image processor is further configured to generate a synthetic mammogram of the breast from projection tomosynthesis images.

11 . The system of claim 1 in which the source is configured to emit radiation that contributes to a substantially constant photon count at the receptor for substantially all projection images ETp 1 and ETp 2 .

12 . An x-ray breast imaging system having multiple modes of operation comprising:
a breast immobilizer configured to flatten a patient's breast in an imaging volume; an x-ray source and an x-ray imaging receptor configured to selectively operate in any one of the following system modes: (a) a mammography mode M, (b) a tomosynthesis mode T, and (c) an enhanced tomosynthesis mode ET; wherein (a) when in mode M the system produces a mammogram image Mp taken while the source and receptor are at fixed positions relative to the immobilizer, (b) when in mode T the system produces plural two-dimensional (2D) projection images Tp each taken from a respective position of the source in a source trajectory T around the immobilizer, and (c) when operating in mode ET the system produces 2D projection images ETp 1 taken from respective positions of the source in a first source trajectory ET 1 around the breast immobilizer and 2D projection images ETp 2 taken from respective positions of the source in a second source trajectory ET 2 around the immobilizer; a computer-implemented image processor configured to: (a) respond to mode M operation to process the image Mp into a display mammogram image Mpd, (b) respond to mode T operation to apply a first tomosynthesis image reconstruction processing to the images Tp and thereby produce reconstructed breast slice images Tr, and (c) respond to mode ET operation to apply a second tomosynthesis image reconstruction processing to the images ETp 1 and ETp 2 to produce reconstructed breast slice images ETr; wherein the spatial resolution at least in a breast compression direction is greater in one of images Tr and ETr than in the other of images Tr and ETr; and a display configured to selectively display images derived from one or more of images Mpd, Tr, and ETr.

13 . The system of claim 12 including a patient shield surrounding at least the first and second trajectories, which patient shield has a central opening in which the breast immobilizer is located and which is sufficiently large for a patient to insert her arm when her breast is in the breast immobilizer such that at least a significant part of the patient's axilla is in the imaging volume.

14 . The system of claim 13 in which the breast immobilizer is configured to move between a central position the shield opening for operation in the ET mode and a position at a circumferential periphery of the central opening for operation in at least one of the M mode and the T mode.

15 . The system of claim 12 in which mode T includes selective operation in a sub-mode Tn and sub-mode Tw, wherein the source trajectory in mode Tn is shorter than in mode Tw.

16 . The system of claim 12 including an anti-scatter grid between the immobilizer and the receptor in at least one of the T mode operation and the ET mode operation.

17 . The system of claim 12 in which the second tomosynthesis image reconstruction processing is configured to include in the images ETr a greater contribution to low spatial resolution content from images Tp 2 than from images Tp 1 .

18 . The system of claim 12 in which the x-ray source and x-ray imaging receptor are further configured to selectively operate in a CT mode to generate reconstructed slice or volume images CTr of the breast and the display is configured to selectively display images derived from each of images Mpd, Tp, Tr, ETr, and CTr.

19 . An x-ray breast imaging system comprising:
a breast immobilizer configured to flatten a patient's breast; an x-ray source and an x-ray imaging receptor configured to selectively image the breast in a narrow angle tomosynthesis sub-mode Tn and an a wide angle tomosynthesis sub-mode Tw, where in sub-mode Tn the receptor obtains respective two-dimensional (2D) projection tomosynthesis x-ray images Tnp in the course of the source traversing a narrower arc trajectory around the immobilizer and in sub-mode Tw the receptor obtains respective 2D projection images Twp in the course of the source traversing a wider arc trajectory around the immobilizer; a computer-implemented image processor configured to selectively operate in a Tn mode to apply tomosynthesis image reconstruction processing to im

Assignees

• Hologic Inc
• Hologic Inc

Inventors

• Smith Andrew P
• Stein Jay A
• Defreitas Ken
• Shaw Ian
• Jing Zhenxue
• Niklason Loren
• Ren Baorui
• Ruth Christopher

Classifications

• A61B6/502 Primary

  for diagnosis of breast, i.e. mammography · CPC title

• A61B6/107

  Protection against radiation, e.g. shielding · CPC title

• A61B6/5223

  generating planar views from image data, e.g. extracting a coronal view from a 3D image · CPC title

• A61B6/54

  Control of apparatus or devices for radiation diagnosis · CPC title

• A61B6/025

  Tomosynthesis · CPC title