Filamentary devices for treatment of vascular defects

Patent metadata

Field	Value
Publication number	US-2016249934-A1
Application number	US-201514684079-A
Country	US
Kind code	A1
Filing date	Apr 10, 2015
Priority date	Aug 16, 2013
Publication date	Sep 1, 2016
Grant date	—

Abstract

Devices and methods for treatment of a patient's vasculature are described. The devices include implants made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Additionally, there is a transition zone between the two regions. The implants have a low profile radially constrained state and an expanded state that is axially shortened. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described.

First claim

1 . A device for treating a cerebral aneurysm, comprising:
an implant comprising woven braided mesh, the implant having a proximal end with a hub, a distal end, and a longitudinal axis extending from the proximal end to the distal end; the implant having a distal region, a proximal region, and a transition region that lies substantially perpendicular to the longitudinal axis of the implant and extends between the distal and proximal regions; the implant having an expanded configuration when deployed, the expanded implant having a region of maximum diameter that extends from a proximal portion of the distal region through the transition region and to a distal portion of the proximal region, wherein a diameter of a pore within the proximal portion of the distal region is larger than all pores in the distal portion of the proximal region.

2 . The device of claim 1 , wherein the diameter of a pore in the proximal portion of the distal region is greater than 300 μm.

3 . The device of claim 1 , wherein the diameter of a pore in the proximal portion of the distal region is between about 300 μm and about 900 μm.

4 . The device of claim 1 , wherein the diameter of a pore in the proximal portion of the distal region is in a range selected from the group consisting of about 300 μm to about 900 μm, about 300 μm to about 700 μm, and about 300 μm to about 500 μm.

5 . The device of claim 1 , wherein the diameter of a pore in the distal portion of the proximal region is less than 200 μm.

6 . The device of claim 1 , wherein the diameter of a pore in the distal portion of the proximal region is between about 50 μm and about 200 μm.

7 . The device of claim 1 , wherein the diameter of a pore in the distal portion of the proximal region is in a range selected from the group consisting of about 50 μm to about 200 μm, about 50 μm to about 150 μm, and about 100 μm to about 200 μm

8 . The device of claim 1 , wherein the transition region is approximately 1000 μm high.

9 . The device of claim 1 , wherein the transition region has a height that is approximately about 0.5% to about 20% of a total height of the implant.

10 . The device of claim 1 , wherein the transition region has a height that is selected from the group consisting of approximately about 1% to about 15% of a total height of the implant, about 1% to about 10% of a total height of the implant, and about 3% to about 8% of a total height of the implant.

11 . A method for treating a cerebral aneurysm, comprising the steps of:
providing an implant comprising woven braided mesh, the implant having a proximal end with a hub, a distal end, and a longitudinal axis extending from the proximal end to the distal end,
wherein the implant has a distal region, a proximal region, and a transition region that lies substantially perpendicular to the longitudinal axis of the implant and extends between the distal and proximal regions;
wherein the implant has an expanded configuration when deployed, the expanded implant having a region of maximum diameter that extends from a proximal portion of the distal region through the transition region and to a distal portion of the proximal region,
wherein a diameter of a pore within the proximal portion of the distal region is larger than all pores in the distal portion of the proximal region;
advancing the implant in the low profile radially constrained state within a microcatheter to a region of interest within a cerebral artery; deploying the implant within the cerebral aneurysm, wherein the distal and proximal permeable shells expand to their expanded shapes; and withdrawing the microcatheter from the region of interest after deploying the implant.

12 . The method of claim 11 , wherein the diameter of a pore in the proximal portion of the distal region is greater than 300 μm.

13 . The method of claim 11 , wherein the diameter of a pore in the proximal portion of the distal region is between about 300 μm and about 900 μm.

14 . The method of claim 11 , wherein the diameter of a pore in the proximal portion of the distal region is in a range selected from the group consisting of about 300 μm to about 900 μm, about 300 μm to about 700 μm, and about 300 μm to about 500 μm.

15 . The method of claim 11 , wherein the diameter of a pore in the distal portion of the proximal region is less than 200 μm.

16 . The method of claim 11 , wherein the diameter of a pore in the distal portion of the proximal region is between about 50 μm and about 200 μm.

17 . The method of claim 11 , wherein the diameter of a pore in the distal portion of the proximal region is in a range selected from the group consisting of about 50 μm to about 200 μm, about 50 μm to about 150 μm, and about 100 μm to about 200 μm

18 . The method of claim 11 , wherein the transition region is approximately 1000 μm high.

19 . The method of claim 11 , wherein the transition region has a height that is approximately about 0.5% to about 20% of a total height of the implant.

20 . The method of claim 11 , wherein the transition region has a height that is selected from the group consisting of approximately about 1% to about 15% of a total height of the implant, about 1% to about 10% of a total height of the implant, and about 3% to about 8% of a total height of the implant.

21 - 181 . (canceled)

Assignees

• Sequent Medical Inc

Inventors

• Hewitt Todd
• Merritt Brian
• Patterson William R
• Thompson James M
• Plaza Claudio
• Tran Hung P

Classifications

• A61B17/12145

  having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526) · CPC title

• A61B17/12113 Primary

  within an aneurysm · CPC title

• A61B2017/00862

  elastic or resilient · CPC title

• A61B17/12031

  complete occlusion · CPC title

• A61B2017/00292

  mounted on or guided by flexible, e.g. catheter-like, means · CPC title