Quinazoline Derivatives, Compositions, and Uses Related Thereto

Patent metadata

Field	Value
Publication number	US-2016243121-A1
Application number	US-201615147531-A
Country	US
Kind code	A1
Filing date	May 5, 2016
Priority date	May 31, 2012
Publication date	Aug 25, 2016
Grant date	—

Abstract

The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or myeloperoxidase.

First claim

1 . A pharmaceutical composition comprising a compound 3-amino-6-fluoro-2-thioxo-2,3-dihydroquinazolin-4(1H)-one optionally substituted with one or more, the same or different, substituents or salts thereof.

2 . A method of treating a NOX- or MPO-related disease comprising administering a pharmaceutical composition of claim 1 to a subject in need thereof.

3 . The method of claim 2 , wherein the NOX- or MPO-related disease is selected from hypertension, ischemia/reperfusion injury, stroke, myocardial infarction, diabetes, atherosclerosis, Alzheimer's disease, chronic obstructive pulmonary disease, asthma, inflammatory bowel disease, cystic fibrosis, schizophrenia, asbestos lung injury, multiple sclerosis, chronic heart failure, rheumatoid arthritis, glomerulonephritis, various cancers, acute respiratory distress syndrome, acute lung inflammation, Parkinson's disease, pulmonary fibrosis, liver fibrosis, cardiac hypertrophy, diabetic nephropathy, diabetic neuropathy, scar formation, skin aging and damage, and psoriasis.

4 . A method of preventing aging, sunburn, or scar formation comprising administering a composition comprising a compound of claim 1 to a subject in need thereof.

5 . A method of preventing tissue injury comprising administering a composition comprising a compound of claim 1 to subject before, during or after and organ transplant.

6 . An aqueous biological storage medium comprising a compound of claim 1 .

7 . The biological storage medium of claim 6 , further comprising a salt, an amino acid, a saccharide, a vitamin, or adenosine triphosphate.

Assignees

• Univ Emory

Inventors

• Lambeth John David
• Ganesh Thota
• Smith Susan M
• Sun Aiming

Classifications

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• C07D403/06

  linked by a carbon chain containing only aliphatic carbon atoms · CPC title

• C07D239/95

  with hetero atoms directly attached in positions 2 and 4 · CPC title

• A61Q17/04

  Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations · CPC title

• A61K31/517 Primary

  ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine · CPC title