Method for producing porous cellulose beads

Patent metadata

Field	Value
Publication number	US-2016236171-A1
Application number	US-201415028632-A
Country	US
Kind code	A1
Filing date	Oct 14, 2014
Priority date	Oct 15, 2013
Publication date	Aug 18, 2016
Grant date	—

Abstract

The present invention provides a method for easily and efficiently producing cellulose beads which has narrow pore size distribution and pore structure suitable for an adsorbent and of which adsorption performance is excellent without using highly toxic and highly corrosive auxiliary raw material and without industrially disadvantageous cumbersome step. The method for producing porous cellulose beads according to the present invention is characterized in comprising (a) the step of preparing a fine cellulose dispersion by mixing a low temperature alkaline aqueous solution and cellulose, (b) the step of preparing a mixed liquid by adding a water-soluble low molecular organic compound to the fine cellulose dispersion, (c) the step of preparing an emulsion by dispersing the mixed liquid in a dispersion medium, (d) the step of contacting the emulsion with a coagulating solvent.

First claim

1 : A method for producing porous cellulose beads, comprising
(a) the step of preparing a fine cellulose dispersion by mixing a low temperature alkaline aqueous solution and cellulose, (b) the step of preparing a mixed liquid by adding a water-soluble low molecular organic compound to the fine cellulose dispersion, (c) the step of preparing an emulsion by dispersing the mixed liquid in a dispersion medium, (d) the step of contacting the emulsion with a coagulating solvent.

2 : The method according to claim 1 , wherein the temperature of the alkaline aqueous solution in the step (a) is not less than 0° C. and not more than 25° C.

3 : The method for producing porous cellulose beads according to claim 1 , wherein the water-soluble low molecular organic compound is an amino acid.

4 : The method for producing porous cellulose beads according to claim 1 , wherein the water-soluble low molecular organic compound is one or more amino acids selected from the group consisting of glycine, alanine, serine, threonine, asparagine, glutamine, aspartic acid, glutamic acid, lysine, arginine and histidine.

5 : The method for producing porous cellulose beads according to claim 1 , wherein the dispersion medium is one or more oil-soluble solvents selected from the group consisting of an animal and plant fat and oil, a hydrogenated animal and plant fat and oil, a fatty acid triglyceride, an aliphatic hydrocarbon solvent and an aromatic hydrocarbon.

6 : The method for producing porous cellulose beads according to claim 1 , wherein the coagulating solvent is an alcohol solvent or a mixed solvent of water and an alcohol solvent.

7 : An adsorbent, obtained by immobilizing a ligand capable of interacting with a target substance on the beads produced by the method for producing porous cellulose beads according to claim 1 .

8 : An adsorbent, comprising the porous cellulose beads produced by the method according to claim 1 and a ligand capable of interacting with a target substance.

9 : A method for producing an adsorbent, comprising the step of immobilizing a ligand capable of interacting with a target substance on the porous cellulose beads produced by the method according to claim 1 .

10 : A purification method, comprising the step of using the adsorbent according to claim 7 .

11 : A purification method, comprising the step of using the adsorbent according to claim 8 .

Assignees

• Kaneka Corp

Inventors

• Hirano Masaru
• Watanabe Kana

Classifications

• B01J20/285

  based on polymers · CPC title

• B01J20/3085

  Chemical treatments not covered by groups B01J20/3007 - B01J20/3078 · CPC title

• B01D15/3828

  Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography · CPC title

• C07K1/22

  Affinity chromatography or related techniques based upon selective absorption processes · CPC title

• B01J20/24 Primary

  Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives · CPC title