Germanium-based glass polyalkenoate cement

Patent metadata

Field	Value
Publication number	US-2016235884-A1
Application number	US-201615136728-A
Country	US
Kind code	A1
Filing date	Apr 22, 2016
Priority date	May 3, 2012
Publication date	Aug 18, 2016
Grant date	—

Abstract

Disclosed herein are compositions and methods for making germanium-based glass polyalkenoate cements. Also disclosed are methods for their use as bone cements for bone augmentation procedures.

First claim

1 . (canceled)

2 . A method of augmenting bone, comprising:
injecting a cement into a bone of a subject, the cement comprising a mixture of:
(a) an acid degradable glass powder comprising:
0.1-0.75 mole fraction GeO 2 ;
0.11-0.53 mole fraction ZnO; and
0.02-0.48 mole fraction SiO 2 ;
wherein the acid degradable glass powder comprises no more than 0.01 mole fraction aluminosilicates, and

(b) an aqueous solution of about 40% to about 60% by weight of a polyalkenoic acid that has a weight average molecular weight (Mw) of about 1,150 to about 1,500,000,
wherein the acid degradable glass powder and the aqueous solution are in a ratio of about 2:1 to about 1:1 (w:w).

3 . The method of claim 2 , further comprising allowing the injected cement to harden.

4 . The method of claim 2 , wherein the SiO 2 and the GeO 2 are present in a ratio of about 2:1 to about 1:3 (SiO 2 :GeO 2 ).

5 . The method of claim 2 , wherein the SiO 2 and the GeO 2 are present in a ratio of about 1:1 (SiO 2 :GeO 2 ).

6 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.025-0.12 mole fraction SrO.

7 . The method of claim 2 , wherein the acid degradable glass powder further comprises about 0.04 mole fraction SrO.

8 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.005-0.08 mole fraction each of ZrO 2 and Na 2 O.

9 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.005-0.06 mole fraction each of ZrO 2 and Na 2 O.

10 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.005-0.04 mole fraction each of ZrO 2 and Na 2 O.

11 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.01-0.055 mole fraction each of ZrO 2 and Na 2 O.

12 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.02-0.04 mole fraction each of ZrO 2 and Na 2 O.

13 . The method of claim 2 , wherein the acid degradable glass powder comprises 0.1-0.6 mole fraction GeO 2 .

14 . The method of claim 2 , wherein the acid degradable glass powder comprises 0.2-0.5 mole fraction GeO 2 .

15 . The method of claim 2 , wherein the acid degradable glass powder comprises 0.35-0.5 mole fraction GeO 2 .

16 . The method of claim 2 , wherein the acid degradable glass powder comprises about 0.36 mole fraction ZnO.

17 . The method of claim 2 , wherein the acid degradable glass powder comprises 0.02-0.25 mole fraction SiO 2 .

18 . The method of claim 17 , wherein the acid degradable glass powder comprises 0.02-0.2 mole fraction SiO 2 .

19 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.01-0.35 mole fraction CaO.

20 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.02-0.16 mole fraction CaO.

21 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.02-0.12 mole fraction CaO.

22 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.05-0.15 mole fraction CaO.

23 . The method of claim 2 , wherein the acid degradable glass powder further comprises 0.07-0.13 mole fraction CaO.

24 . The method of claim 2 , wherein the acid degradable glass powder is substantially free of aluminosilicates.

25 . The method according to claim 2 :
wherein the glass powder comprises:
0.012 mole fraction SiO 2 , 0.468 mole fraction GeO 2 , 0.017 combined mole fraction ZrO 2 /Na 2 O, and 0.103 mole fraction CaO; or
0.057 mole fraction SiO 2 , 0.381 mole fraction GeO 2 , 0.047 combined mole fraction ZrO 2 /Na 2 O, and 0.115 mole fraction CaO; or
0.130 mole fraction SiO 2 , 0.350 mole fraction GeO 2 , 0.029 combined mole fraction ZrO 2 /Na 2 O, and 0.091 mole fraction CaO; or
0.021 mole fraction SiO 2 , 0.459 mole fraction GeO 2 , 0.019 combined mole fraction ZrO 2 /Na 2 O, and 0.101 mole fraction CaO; or
0.318 mole fraction SiO 2 , 0.162 mole fraction GeO 2 , 0.032 combined mole fraction ZrO 2 /Na 2 O, and 0.088 mole fraction CaO;
wherein the glass powder further comprises zinc and strontium components.

26 . The method according to claim 25 , wherein the zinc and strontium components comprise 0.36 mole fraction ZnO and 0.04 mole fraction SrO.

27 . The method according to claim 25 , wherein the combined mole fraction ZrO 2 /Na 2 O is equal mole fractions of ZrO 2 and Na 2 O.

28 . The method according to claim 2 , wherein the glass powder comprises:
0.215 mole fraction SiO 2 , 0.215 mole fraction GeO 2 , 0.050 combined mole fraction ZrO 2 /Na 2 O, and 0.120 mole fraction CaO; wherein the glass powder further comprises zinc and strontium components.

29 . The method according to claim 28 , wherein the zinc and strontium components comprise 0.36 mole fraction ZnO and 0.04 mole fraction SrO.

30 . The method according to claim 28 , wherein the combined mole fraction ZrO 2 /Na 2 O is equal mole fractions of ZrO 2 and Na 2 O.

31 . The method according to claim 2 , wherein the polyalkenoic acid is polyacrylic acid.

32 . The method according to claim 2 , wherein the polyalkenoic acid has a weight average molecular weight (Mw) of about 1,150 to 383,000.

33 . The method according to claim 2 , wherein the polyalkenoic acid has a weight average molecular weight (Mw) of about 1,150 to 114,000.

34 . The method according to claim 2 , wherein the polyalkenoic acid has a weight average molecular weight (Mw) of about 1,150 to 22,700.

35 . The method according to claim 2 , wherein the polyalkenoic acid has a weight average molecular weight (Mw) of about 12,700.

36 . The method according to claim 2 , wherein the acid degradable glass powder and the aqueous solution are in a ratio of about 2:1.5 (w:w).

37 . The method according to claim 2 , wherein injecting the cement into a bone comprises injecting the cement into a bone fracture.

38 . The method according to claim 37 , further comprising inflating a balloon tamp inserted into the bone fracture prior to injecting the cement.

39 . The method according to claim 2 , wherein injecting the cement into a bone comprises injecting the cement through a percutaneous cannulae into a fractured vertebra.

40 . The method according to claim 39 , wherein the fractured vertebra is a collapsed fractured vertebra, and the method further comprises, prior to injecting the cement through the percutaneous cannulae: creating a cavity in the collapsed fractured vertebra, restoring the height of the collapsed fractured vertebra, or both.

41 . The method according to claim 40 , wherein the method comprises inflating a balloon tamp inserted into the bone fracture to create the cavity in the collapsed fractured vertebra, restore the height of the collapsed fractured vertebra, or both.

Assignees

• Univ Dalhousie

Inventors

• Dickinson Victoria
• Boyd Daniel
• Dickey Brett
• Kehoe Sharon

Classifications

• C03C12/00

  Powdered glass (C03C8/02 takes precedence); Bead compositions · CPC title

• A61L24/02

  containing inorganic materials · CPC title

• C03C3/062

  with less than 40% silica by weight · CPC title

• A61B17/7097

  Stabilisers comprising fluid filler in an implant, e.g. balloon; devices for inserting or filling such implants (disc prostheses made of inflatable chambers or pockets filled with fluid A61F2/441; replacing the nucleus pulposus A61F2002/444) · CPC title

• C03C3/078

  containing an oxide of a divalent metal, e.g. an oxide of zinc · CPC title