Multi-arm polymeric prodrug conjugates of taxane-based compounds

Patent metadata

Field	Value
Publication number	US-2016235705-A1
Application number	US-201615045077-A
Country	US
Kind code	A1
Filing date	Feb 16, 2016
Priority date	Dec 22, 2010
Publication date	Aug 18, 2016
Grant date	—

Abstract

Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of taxane-based compounds and/or fluorinated forms thereof. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the taxane-based compound is achieved.

First claim

1 - 24 . (canceled)

25 . A conjugate selected from the group consisting of:

wherein each n is a positive integer from 10 to about 400, and pharmaceutically acceptable salts of each of the foregoing.

26 . A composition comprising a plurality of conjugates, wherein at least 80% of the conjugates in the composition have a structure encompassed by claim 25 .

27 . The composition of claim 26 , further comprising a pharmaceutical excipient.

Assignees

• Nektar Therapeutics

Inventors

• Kozlowski Antoni
• Riley Timothy A
• Mcmanus Samuel P

Classifications

• C08L2203/02

  for biomedical use · CPC title

• C07D305/14

  condensed with carbocyclic rings or ring systems · CPC title

• A61K47/60

  the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol · CPC title

• A61K31/337 Primary

  having four-membered rings, e.g. taxol · CPC title

• C08G65/329

  with organic compounds · CPC title