Manufacturing method of stent and coating device

Patent metadata

Field	Value
Publication number	US-2016235565-A1
Application number	US-201615070270-A
Country	US
Kind code	A1
Filing date	Mar 15, 2016
Priority date	Sep 27, 2013
Publication date	Aug 18, 2016
Grant date	—

Abstract

A manufacturing method of a stent is disclosed which prevents a drug from being peeled off or separated due to stress concentration or distortion resulting from the expanding deformation of the stent so that the drug is further uniformly effective and further improved yields are expected when the stent is manufactured, and a coating device. The method has a non-coating portion forming process of preventing a bending portion from being coated with the drug by causing a nozzle to go past the bending portion when the nozzle reaches the bending portion and to move toward main strut portions. In the non-coating portion forming process, an adhesion amount of a coating solution is reduced while the nozzle is going past the bending portion.

First claim

What is claimed is:

1 . A manufacturing method of a stent that has an annular body configured to include a waved strut which at least has first and second main strut portions to be coated with a drug and a bending portion formed between the first and second main strut portions, the method comprising:
a drug coating process of coating the stent with the drug, wherein the drug coating process comprises a non-coating portion forming process including coating an outer surface of the first main strut portion with the drug by causing a nozzle for discharging a coating solution prepared by dissolving the drug and a polymer in a solvent to move along the first main strut portion, and when the nozzle reaches the bending portion, preventing the bending portion from being coated with the drug by causing the nozzle to go past the bending portion and to move toward the second main strut portion, and wherein in the non-coating portion forming process, an adhesion amount of the coating solution adhering to the nozzle is reduced while the nozzle is going past the bending portion.

2 . The manufacturing method of the stent according to claim 1 ,
wherein in the non-coating portion forming process, a discharge amount of the coating solution from the nozzle is changed while the nozzle is going past the bending portion.

3 . The manufacturing method of the stent according to claim 1 ,
wherein in the non-coating portion forming process, the nozzle is closed while the nozzle is going past the bending portion.

4 . The manufacturing method of the stent according to claim 1 ,
wherein in the non-coating portion forming process, the coating solution adhering to the nozzle is removed while the nozzle is going past the bending portion.

5 . The manufacturing method of the stent according to claim 1 ,
wherein in the drug coating process, a thickness of a drug coating layer is adjusted by discharging the coating solution from the nozzle while moving the nozzle along the strut so that the thickness of the drug coating layer of the first main strut portion and the second main strut portion gradually decreases toward the bending portion.

6 . The manufacturing method of the stent according to claim 1 ,
wherein a plurality of the annular bodies are juxtaposed along an axial direction of the stent, wherein the strut further has a link portion for integrating the adjacent annular bodies with each other, and wherein in the drug coating process, a non-coating portion forming process of preventing the link portion from being coated with the drug is further performed by moving the nozzle so as to go past the link portion when the nozzle reaches the link portion, and an adhesion amount of the coating solution adhering to the nozzle is reduced in the non-coating portion forming process.

7 . The manufacturing method of the stent according to claim 1 ,
wherein the coating solution is continuously supplied when the nozzle is separated from the first main strut portion, the supply of the coating solution is stopped while the nozzle is going past the bending portion, and the supply of the coating solution restarts before the nozzle reaches the second main strut portion.

8 . A coating device for coating, with a drug, a stent that has an annular body configured to include a waved strut which at least has first and second main strut portions to be coated with the drug and a bending portion formed between the first and second main strut portions, comprising:
a holding tool by which the stent is held; a nozzle that discharges a coating solution prepared by dissolving the drug and a polymer in a solvent; moving means for relatively moving the holding tool and the nozzle so that a predetermined portion of the stent is coated with the coating solution; and a control unit that controls an operation of each unit in the coating device, wherein an outer surface of the first main strut portion is coated with the drug by moving the nozzle along the first main strut portion, the bending portion is prevented from being coated with the drug by causing the nozzle to go past the bending portion when the nozzle reaches the bending portion and to move toward the second main strut portion, and an adhesion amount of the coating solution adhering to the nozzle is reduced while the nozzle is going past the bending portion.

9 . The coating device according to claim 8 ,
wherein the control unit changes a discharge amount of the coating solution from the nozzle while the nozzle is going past the bending portion.

10 . The coating device according to claim 8 , comprising:
coating solution reducing means for reducing the adhesion amount of the coating solution adhering to the nozzle.

11 . The coating device according to claim 10 ,
wherein the coating solution reducing means has a nozzle closing portion which closes the nozzle.

12 . The coating device according to claim 10 ,
wherein the coating solution reducing means has a coating solution removing portion which removes the coating solution adhering to the nozzle.

13 . The coating device according to claim 12 ,
wherein the coating solution removing portion has at least one of a cleaning portion for cleaning the nozzle, a collecting portion for collecting the coating solution, and a suctioning and discharging portion for suctioning or discharging the coating solution.

14 . The coating device according to claim 8 ,
wherein a plurality of the annular bodies are juxtaposed along an axial direction of the stent, wherein the strut further has a link portion for integrating the adjacent annular bodies with each other, and wherein the coating device prevents the link portion from being coated with the drug by moving the nozzle so as to go past the link portion when the nozzle reaches the link portion, and reduces an adhesion amount of the coating solution adhering to the nozzle while the nozzle is going past the link portion.

15 . The coating device according to claim 8 ,
wherein the coating solution is continuously supplied when the nozzle is separated from the first main strut portion, the supply of the coating solution is stopped while the nozzle is going past the bending portion, and the supply of the coating solution restarts before the nozzle reaches the second main strut portion.

16 . A manufacturing method of a stent that has an annular body configured to include a waved strut which at least has first and second main strut portions to be coated with a drug and a bending portion formed between the first and second main strut portions, the method comprising:
coating an outer surface of the first main strut portion with the drug by causing a nozzle for discharging a coating solution prepared by dissolving the drug and a polymer in a solvent to move along the first main strut portion, and when the nozzle reaches the bending portion, preventing the bending portion from being coated with the drug by causing the nozzle to go past the bending portion and to move toward the second main strut portion; and reducing an adhesion amount of the coating solution adhering to the nozzle while the nozzle is going past the bending portion.

17 . The manufacturing method of the stent according to claim 16 , comprising:
changing a discharge amount of the coating solution from the nozzle while the nozzle is going past the bending portion.

18 . The manufacturing method of the stent according to claim 16 , comprising:
closing the nozzle while the nozzle is going past the bending portion.

19 . The manufacturing me

Assignees

• Terumo Corp

Inventors

• Maruyama Kazuhiro
• Kuroda Yasuyuki
• Watanabe Masaki
• Takeda Kazuyuki

Classifications

• A61F2/91 Primary

  made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes · CPC title

• B05C5/0216

  by relative movement of article and outlet according to a predetermined path · CPC title

• B05B14/00

  Arrangements for collecting, re-using or eliminating excess spraying material (arrangements integral with nozzles B05B1/28) · CPC title

• A61F2250/0067

  Means for introducing or releasing pharmaceutical products into the body · CPC title

• B05D1/02

  performed by spraying · CPC title