Alignment of elongated particles in a particle delivery device

Patent metadata

Field	Value
Publication number	US-2016228646-A1
Application number	US-201514617415-A
Country	US
Kind code	A1
Filing date	Feb 9, 2015
Priority date	Feb 9, 2015
Publication date	Aug 11, 2016
Grant date	—

Abstract

A device for delivery of particles into biological tissue includes at least one conduit and a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit. A particle source is configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w. The propellant source and the conduit are configured to propel the elongated particles in a collimated particle stream toward the biological tissue. An alignment mechanism is configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit. The aligned elongated particles are ejected from the conduit and impact the biological tissue.

First claim

1 . A device for delivery of particles into biological tissue comprising:
at least one conduit; a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit; a particle source configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w, the propellant source and the conduit configured to propel the elongated particles in a collimated particle stream toward the biological tissue; an alignment mechanism configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit, wherein the aligned elongated particles are ejected from the conduit and impact the biological tissue.

2 . The device of claim 1 , wherein the alignment mechanism comprises an aerodynamic alignment mechanism that includes:
a source of sheath fluid; and one more ports in the conduit configured to allow entry of the sheath fluid into the conduit in one or more sheath streams adjacent to the particle stream, the one or more sheath streams configured to align the longitudinal axis of the elongated particles along the direction of the particle stream in the alignment region.

3 . The device of claim 1 , wherein:
the elongated particles are electrically charged; and the alignment mechanism comprises an electrostatic alignment mechanism comprising one or more charged plates arranged proximate to the conduit.

4 . The device of claim 1 , wherein:
the elongated particles are magnetic; and the alignment mechanism comprises a magnetic field generator that generates a magnetic field within the conduit.

5 . The device of claim 1 , wherein the elongated particles have at least one pointed tip.

6 . The device of claim 1 , wherein the elongated particles have one or more fins.

7 . The device of claim 6 , wherein the fins are configured to break off or fold back when the elongated particles penetrate the biological tissue.

8 . The device of claim 1 , wherein the elongated particles are solid particles of a functional material that interacts with the biological tissue.

9 . The device of claim 1 , wherein the elongated particles include at least a first material and a second material, wherein the second material is a functional material that interacts with the biological tissue and the first material is a biologically inert material that has higher density than the second material.

10 . The device of claim 9 , wherein a volume of the second material is greater than a volume of the first material.

11 . The device of claim 1 , further comprising a particle accelerator downstream from the alignment mechanism, the particle accelerator configured to accelerate the elongated particles toward the biological tissue.

12 . The device of claim 1 , wherein the elongated particles comprise a drug, a cosmetic, a biologically nourishing material, or a marking material.

13 . The device of claim 1 , further comprising an additional particle source configured to release additional particles into the particle stream, wherein the elongated particles comprise a functional material that interacts with the biological tissue and the additional particles have a higher density than a density of the elongated particles.

14 . The device of claim 13 , wherein:
the elongated particles are electrostatically charged; the additional particles are oppositely electrostatically charged; and the elongated particles and the additional particles form particle agglomerations as the particles are transported in the particle stream.

15 . A method for delivery of particles into biological tissue comprising:
releasing elongated particles into a conduit; propelling the elongated particles in a collimated particle stream in the conduit, the elongated particles having a width, w, a length, l>w, and an aspect ratio, l/w; aligning a longitudinal axis of the elongated particles to be substantially parallel to a direction of the collimated particle stream; and ejecting the aligned elongated particles from the conduit toward the biological tissue.

16 . The method of claim 15 , wherein aligning the longitudinal axis of elongated particles comprises introducing a sheath fluid into the conduit in one or more sheath streams adjacent to the collimated particle stream, the one or more sheath streams operating to align the longitudinal axis of the elongated particles to be substantially parallel to the direction of the particle stream in an alignment region.

17 . The method of claim 15 , wherein:
the elongated particles are electrically charged; and aligning the elongated particles comprises electrostatically aligning the elongated particles.

18 . The method of claim 15 , wherein:
the elongated particles are magnetic; and aligning the elongated particles comprises magnetically aligning the elongated particles.

19 . The method of claim 15 , further comprising accelerating the aligned elongated particles in the particles stream toward the biological tissue using an electrostatic particle accelerator.

20 . The method of claim 15 , wherein each of the elongated particles comprises one or more of increased density at one end of the elongated particle and an aerodynamic drag feature.

21 . The method of claim 15 , further comprising pre or post treating the biological tissue before or after ejecting the aligned elongated particles from the conduit toward the biological tissue.

22 . The method of claim 21 , wherein the pre or post treating comprises at least one of a laser treatment, a magnetic treatment, an electromagnetic treatment, an ultrasonic treatment and a chemical treatment.

23 . A device for delivery of particles into biological tissue comprising:
at least one conduit; a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit; a particle source configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w, the propellant source and the conduit configured to accelerate the elongated particles in a collimated particle stream toward the biological tissue, wherein acceleration of the particles by the propellant aligns a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream.

24 . The device of claim 23 , wherein each of the elongated particles includes at least one of:
a feature that provides enhanced aerodynamic drag; and increased density at one end of the particle.

Assignees

• Palo Alto Res Ct Inc

Inventors

• Biegelsen David K
• Chow Eugene M
• Volkel Armin R
• Pattekar Ashish
• Veiseh Mandana

Classifications

• A61M5/2046

  Media being expelled from injector by gas generation, e.g. explosive charge · CPC title

• A61M5/2053

  Media being expelled from injector by pressurised fluid or vacuum (for infusion A61M5/145, A61M5/155) · CPC title

• A61M2202/064

  Powder · CPC title

• A61M5/3015 Primary

  for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow (cell injection devices C12M3/006) · CPC title

• A61M2037/0007

  having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents · CPC title