Scaffold

Patent metadata

Field	Value
Publication number	US-2016228608-A1
Application number	US-201415026830-A
Country	US
Kind code	A1
Filing date	Oct 2, 2014
Priority date	Oct 4, 2013
Publication date	Aug 11, 2016
Grant date	—

Abstract

A scaffold for tissue repair or wound dressing comprising: a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

First claim

1 . A scaffold for tissue repair or wound dressing comprising:
a material layer; a polymer fibre layer; and an adhesive component between the material layer and the polymer fibre layer, wherein the adhesive component comprises material having a lower melting temperature (Tm) than the material layer and the polymer fibre layer.

2 . The scaffold of claim 1 , wherein the scaffold is biodegradable.

3 . The scaffold of claim 1 , wherein the material layer and polymer fibre layer are bonded to, and via, the adhesive component.

4 . The scaffold of claim 1 , wherein the polymer fibre layer, material layer and/or the adhesive component comprises or consists of electrospun polymer.

5 .- 6 . (canceled)

7 . The scaffold of claim 1 , wherein the polymer fiber layer, material layer and/or the adhesive component comprises a thermoplastic electrospun polymer.

8 .- 10 . (canceled)

11 . The scaffold of claim 4 , wherein the polymer comprises polydioxanone (PDO).

12 . The scaffold of claim 1 , wherein, the material layer and/or polymer fibre layer have a melting temperature (Tm) of at least about 70° C.

13 . The scaffold of claim 1 , wherein the material layer comprises or consists of a woven component.

14 . (canceled)

15 . The scaffold of claim 1 , wherein the polymer fibre layer and/or adhesive component are formed from fibres.

16 .- 17 . (canceled)

18 . The scaffold of claim 1 , wherein the material layer and the polymer layer comprise substantially the same polymer.

19 . (canceled)

20 . The scaffold of claim 1 , wherein the adhesive component has a melting temperature (Tm) of less than about 70° C.

21 . (canceled)

22 . The scaffold of according to any preceding claim 1 , wherein the adhesive component comprises polycaprolactone (PCL).

23 . The scaffold of claim 1 , wherein the scaffold comprises two or more layers of the material layer and/or polymer fibre layer.

24 . (canceled)

25 . The scaffold of claim 1 , wherein the scaffold comprises one or more agents dispersed or impregnated therein; or coated or seeded thereon.

26 . (canceled)

27 . The scaffold of claim 1 , wherein the scaffold has a tensile strength of at least 30 Mpa and/or a breaking strain of at least 25%.

28 . The scaffold of claim 1 , wherein the scaffold comprises cells.

29 . The scaffold of claim 1 , wherein the adhesive component comprises polymer fibres electrospun into a grid.

30 .- 33 . (canceled)

34 . A method of treatment for a condition requiring the repair or replacement of damaged or degenerated tendon, ligament, bone and/or cartilage, comprising the use of the scaffold of claim 1 to repair, supplement or replace tissue.

35 . A method of treatment for a wound, comprising the application of the scaffold of claim 1 to the wound.

36 . A method of producing a scaffold for tissue repair comprising the steps of:
laying a material layer onto a polymer fibre layer with an adhesive component there between to form a layered material; and heating the layered material to a temperature above the melting temperature of the adhesive component and then cooling the layered material to a temperature below the melting temperature of the adhesive component, thereby bonding the layered material together to form a biodegradable scaffold.

37 .- 49 . (canceled)

50 . A scaffold patch comprising the scaffold of claim 1 .

51 .- 54 . (canceled)

Assignees

• Isis Innovation

Inventors

• Hakimi Osnat
• Mouthuy Pierre-Alexis
• Baboldashti Nasim Zargar
• Carr Andrew

Classifications

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L27/38 Primary

  containing added animal cells (organs or tissue containing native cells A61L27/36) · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title

• A61F13/02

  Adhesive bandages or dressings · CPC title