Tunable Nonfouling Surface Of Oligoethylene Glycol

Patent metadata

Field	Value
Publication number	US-2016222218-A1
Application number	US-201615093305-A
Country	US
Kind code	A1
Filing date	Apr 7, 2016
Priority date	Feb 20, 2004
Publication date	Aug 4, 2016
Grant date	—

Abstract

An article having a nonfouling surface thereon is comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer, preferably by the process of surface-initiated polymerization of monomeric units thereon, with each of the monomeric units comprising a monomer core group having at least one protein-resistant head group coupled thereto, to thereby form a brush molecule on the surface portion. The brush molecule comprising a stem formed from the polymerization of the monomer core groups, and a plurality of branches formed from the hydrophilic head group projecting from the stem. Methods of making and using such articles, are also described.

First claim

1 - 50 . (canceled)

51 . An article having a nonfouling surface thereon, said article comprising:
(a) a substrate having a surface portion; (b) a linking layer on said surface portion; and (c) a polymer layer formed on said linking layer by the process of surface-initiated polymerization of monomeric units thereon, with each of said monomeric units comprising a monomer core group having at least one protein-resistant head group coupled thereto, to thereby form a brush molecule on said surface portion; said brush molecule comprising a stem formed from the polymerization of said monomer core groups, and a plurality of branches formed from said hydrophilic head group projecting from said stem.

52 . A method of using an article of claim 1 , comprising: (a) providing an article of claim 1 ; and
(b) contacting said article to a biological fluid, and where proteins in said fluid do not bind to said surface portion.

53 . The method of claim 52 , wherein said article further comprises a first member of a specific binding pair coupled to said brush molecule, said first member comprising a single preselected molecule; and said biological fluid contains a second member of said specific binding pair, wherein said second member binds to said first member, and where other proteins or peptides in said fluid do not bind to said first member.

54 . A method of making an article having a nonfouling surface thereon, said method comprising:
(a) providing a substrate having a surface portion; (b) depositing a linking layer on said surface portion; and (c) forming a polymer layer on said linking layer by the process of surface-initiated polymerization of monomeric units thereon, with each of said monomeric units comprising a monomer core group having at least one protein-resistant head group coupled thereto, to thereby form a brush molecule on said surface portion; said brush molecule comprising a stem formed from the polymerization of said monomer core groups, and a plurality of branches formed from said hydrophilic head group projecting from said stem.

Assignees

• Univ Duke

Inventors

• Chilkoti Ashutosh
• Ma Hongwei

Classifications

• A61L27/34 Primary

  Macromolecular materials · CPC title

• C09D4/00

  Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond {; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16} · CPC title

• C09D5/00 Primary

  Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced {(electrically insulating plastics, resins or waxes H01B3/30)}; Filling pastes · CPC title

• G01N33/54393

  Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding · CPC title

• C08J7/16

  with polymerisable compounds · CPC title