Measurement method and measurement device for brown adipose tissue

Patent metadata

Field	Value
Publication number	US-2016220183-A1
Application number	US-201414917581-A
Country	US
Kind code	A1
Filing date	Aug 27, 2014
Priority date	Sep 12, 2013
Publication date	Aug 4, 2016
Grant date	—

Abstract

A measurement method for brown adipose tissue includes a light input step of inputting near-infrared light from a light input unit into a measurement target portion, a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit, and a calculation step of calculating an index value for a BAT amount from an oxygenated hemoglobin concentration or the like of the measurement target portion, which is acquired by near-infrared spectroscopy based on the detection result by the light detection unit.

First claim

1 . A measurement method for brown adipose tissue, comprising:
a light input step of inputting near-infrared light from a light input unit into a measurement target portion; a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit; and a calculation step of calculating an index value for a brown adipose tissue amount from at least one value of an oxygenated hemoglobin concentration, a total hemoglobin concentration, and a first parameter of the measurement target portion, the first parameter increasing or decreasing depending upon the oxygenated hemoglobin concentration or the total hemoglobin concentration, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit.

2 . The measurement method for brown adipose tissue according to claim 1 , wherein the calculation step comprises defining as the index value for the brown adipose tissue amount, a value corrected so as to reduce influence of a body fat amount included in the at least one value, using data indicating a correlation of a second parameter for the body fat amount with the at least one value or with measurement sensitivity.

3 . A measurement method for brown adipose tissue, comprising:
a light input step of inputting near-infrared light from a light input unit into a measurement target portion; a light detection step of detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion by a light detection unit; and a calculation step of calculating an index value for a brown adipose tissue amount from at least one of a scattering coefficient and a deoxygenated hemoglobin concentration of the measurement target portion, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit.

4 . The measurement method for brown adipose tissue according to claim 1 , further comprising a determination step of comparing the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive.

5 . A measurement apparatus for brown adipose tissue, comprising:
a light input unit inputting near-infrared light into a measurement target portion; a light detection unit detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion; and a calculation unit calculating an index value for a brown adipose tissue amount from at least one value of an oxygenated hemoglobin concentration, a total hemoglobin concentration, and a first parameter of the measurement target portion, the first parameter increasing or decreasing depending upon the oxygenated hemoglobin concentration or the total hemoglobin concentration, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit.

6 . The measurement apparatus for brown adipose tissue according to claim 5 , further comprising a storage unit storing data indicating a correlation of a second parameter for a body fat amount with the at least one value or with measurement sensitivity,
wherein the calculation unit defines as the index value for the brown adipose tissue amount, a value corrected so as to reduce influence of the body fat amount included in the at least one value, using the data.

7 . A measurement apparatus for brown adipose tissue, comprising:
a light input unit inputting near-infrared light into a measurement target portion; a light detection unit detecting light intensity of the near-infrared light having propagated through an interior of the measurement target portion; and a calculation unit calculating an index value for a brown adipose tissue amount from at least one of a scattering coefficient and a deoxygenated hemoglobin concentration of the measurement target portion, which are acquired by near-infrared spectroscopy based on the detection result by the light detection unit.

8 . The measurement apparatus for brown adipose tissue according to claim 5 , wherein the calculation unit compares the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive.

9 . The measurement method for brown adipose tissue according to claim 3 , further comprising a determination step of comparing the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive.

10 . The measurement apparatus for brown adipose tissue according to claim 7 , wherein the calculation unit compares the index value with a threshold value to determine whether the brown adipose tissue amount is negative or positive.

Assignees

• Univ Tokyo Medical
• Hamamatsu Photonics Kk

Inventors

• Hamaoka Takafumi
• NIRENGI Shinsuke
• Saito Masayuki
• YONESHIRO Takeshi

Classifications

• A61B5/0059 Primary

  using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455) · CPC title

• A61B5/4872 Primary

  Body fat · CPC title

• A61B5/14551

  for measuring blood gases · CPC title

• G01N21/359

  using near infrared light · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title