Passage timing calculation device, passage timing calculation method, and recording medium for recording program
US-2024352397-A1 · Oct 24, 2024 · US
Method for producing induced pluripotent stem cells
US2016208218A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016208218-A1 |
| Application number | US-201414914986-A |
| Country | US |
| Kind code | A1 |
| Filing date | Aug 28, 2014 |
| Priority date | Aug 28, 2013 |
| Publication date | Jul 21, 2016 |
| Grant date | — |
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Abstract
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A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.
First claim
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1 . A method for producing induced pluripotent stem cells, comprising: bringing a nuclear reprogramming substance including at least a DLX4 gene or a translation product thereof into contact with a cell. 2 . The method according to claim 1 , wherein the nuclear reprogramming substance further includes a gene in an OCT family or a translation product thereof, and a gene in an SOX family or a translation product thereof. 3 . The method according to claim 1 , wherein the nuclear reprogramming substance further includes a gene in a KLF4 family or a translation product thereof. 4 . The method according to claim 2 , wherein the nuclear reprogramming substance further includes a gene in a KLF4 family or a translation product thereof. 5 . The method according to claim 1 , wherein the cell comprises a pulp cell. 6 . The method according to claim 2 , wherein the cell comprises a pulp cell. 7 . The method according to claim 5 , wherein the pulp cell comprises a pulp cell before a stage of completion of tooth root formation. 8 . The method according to claim 6 , wherein the pulp cell comprises a pulp cell before a stage of completion of tooth root formation. 9 . A vector set used for the method according to claim 1 , comprising one or two or more recombinant vectors which retains a DLX4 gene, an OCT3/4 gene and an SOX2 gene. 10 . An induced pluripotent stem cell production agent comprising the vector set according to claim 9 . 11 . iPS cells produced by the vector set according to claim 9 . 12 . An agent used for the method according to claim 1 , including a pulp cell before a stage of completion of tooth root formation and a nuclear reprogramming substance including at least a DLX4 gene or a translation product thereof. 13 . An induced pluripotent stem cell production agent comprising a DLX4 gene or a translation product thereof. 14 . A method for reprogramming a cell nucleus, comprising: bringing a nuclear reprogramming substance including a DLX4 gene, an OCT3/4 gene and an SOX2 gene or a translation product thereof into contact with a cell. 15 . The method according to claim 1 , where the bringing comprises bringing a nuclear reprogramming substance including a DLX4 gene, an OCT3/4 gene and an SOX2 gene or a translation product thereof into contact with a cell.
Assignees
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Classifications
c-Myc · CPC title
Klf-4 · CPC title
Transcription factors · CPC title
Sox-2 · CPC title
Regulators of development · CPC title
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Frequently asked questions
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- What does patent US2016208218A1 cover?
- A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.
- Who is the assignee on this patent?
- Univ Gifu, Nat Inst Of Advanced Ind Scien
- What technology area does this patent fall under?
- Primary CPC classification C12N5/0696. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Jul 21 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).