Antibody titer-increasing agent using lactic acid bacterium

Patent metadata

Field	Value
Publication number	US-2016206733-A1
Application number	US-201414914382-A
Country	US
Kind code	A1
Filing date	Aug 26, 2014
Priority date	Aug 26, 2013
Publication date	Jul 21, 2016
Grant date	—

Abstract

The present invention addresses the problem of providing an antibody titer-increasing agent, such as an adjuvant, capable of sustaining an effect achieved by, for example, vaccination, which is an antibody titer-increasing agent such as an adjuvant that is safe, convenient and economical and can be easily taken irrespective of age, and a method for manufacturing the same. A method for increasing an antibody titer and a method for enhancing the effect of a vaccine, each method comprising using Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof; and an antibody titer-increasing agent such as an adjuvant that comprises Lactobacillus delbrueckii subspecies bulgaricus OLL1073R-1 or a culture thereof.

First claim

1 . An antibody titer-increasing agent comprising Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 and/or a culture thereof.

2 . The antibody titer-increasing agent according to claim 1 , wherein it is an adjuvant.

3 . The antibody titer-increasing agent according to claim 2 , wherein it is an adjuvant for a vaccine.

4 . The antibody titer-increasing agent according to claim 3 , wherein it is an adjuvant for a vaccine for an infectious disease.

5 . The antibody titer-increasing agent according to claim 4 , wherein the infectious disease is influenza.

6 . The antibody titer-increasing agent according to any one of claims 1 to 5 , wherein the culture is a composition obtained by culturing Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 and Streptococcus thermophilus.

7 . The antibody titer-increasing agent according to any one of claims 1 to 6 , wherein it comprises 9×10 7 to 10 12 cfu lactic acid bacteria, including Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1, per package.

8 . The antibody titer-increasing agent according to any one of claims 1 to 7 , wherein it comprises 10 to 1000 g or 10 to 1000 mL per package.

9 . A product formed by packaging the antibody titer-increasing agent according to any one of claims 1 to 8 .

10 . A method (excluding a medical intervention) for increasing an antibody titer, the method comprising a subject ingesting or being made to ingest the antibody titer-increasing agent according to any one of claims 1 to 8 .

11 . The method according to claim 10 , wherein ingestion of 10 to 1000 g or 10 to 1000 mL of the antibody titer-increasing agent per day is continued for at least three weeks.

12 . The method according to claim 11 , wherein ingestion of the antibody titer-increasing agent is continued from at least one week before the date of vaccination.

Assignees

• Meiji Co Ltd

Inventors

• Makino Seiya
• Henmi Jun
• Kano Hiroshi
• Asami Yukio
• Ikegami Shuji
• Itou Hiroyuki
• Suzuki Yoshio
• Kawai Sachio
• Sawaki Keisuke
• Okumura Yasushi
• Nagaoka Isao
• Takeda Kazuyoshi

Classifications

• A61K35/747

  Lactobacilli, e.g. L. acidophilus or L. brevis · CPC title

• A61K2039/55594

  from bacteria · CPC title

• A61P31/16

  for influenza or rhinoviruses · CPC title

• A61K39/39 Primary

  characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title

• A61P37/04

  Immunostimulants · CPC title